TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 259.307 | Formula: C13H17N5O
H donors: 2 H acceptors: 3 LogP: -0.09 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCCC(C1)c1nc2c([nH]1)cncc2C(=O)N
InChi: 1S/C13H17N5O/c1-18-4-2-3-8(7-18)13-16-10-6-15-5-9(12(14)19)11(10)17-13/h5-6,8H,2-4,7H2,1H3,(H2,14,19)(H,16,17)
InChiKey: UUCFXIOLVPMJCD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0219	0.4164	0.3484
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.015	0.241	0.1822
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.015	0.241	0.241
Echinococcus granulosus	insulin receptor	0.015	0.241	0.241
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0219	0.4164	0.3484
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.015	0.241	0.1822
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0219	0.4164	0.4164
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0219	0.4164	0.5022
Echinococcus multilocularis	ephrin type A receptor 4 A	0.015	0.241	0.1527
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.015	0.241	0.5
Echinococcus granulosus	tyrosine kinase	0.015	0.241	0.241
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.015	0.241	0.241
Brugia malayi	hypothetical protein	0.015	0.241	0.1985
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0219	0.4164	0.5022
Echinococcus granulosus	raf serine:threonine protein kinase	0.015	0.241	0.241
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0369	0.793	0.7689
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0219	0.4164	0.3177
Echinococcus multilocularis	tyrosine protein kinase	0.015	0.241	0.1527
Giardia lamblia	Kinase, NEK	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Protein kinase domain containing protein	0.0369	0.793	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.015	0.241	0.1985
Loa Loa (eye worm)	TK/FER protein kinase	0.015	0.241	0.2704
Schistosoma mansoni	tensin	0.0219	0.4164	0.3712
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0369	0.793	0.7689
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Entamoeba histolytica	protein kinase, putative	0.0219	0.4164	0.3177
Echinococcus granulosus	epidermal growth factor receptor	0.015	0.241	0.241
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus multilocularis	SH2 motif	0.0219	0.4164	0.3484
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Plasmodium falciparum	protein kinase, putative	0.015	0.241	0.5
Schistosoma mansoni	tyrosine kinase	0.0369	0.793	0.7769
Schistosoma mansoni	hypothetical protein	0.0219	0.4164	0.3712
Loa Loa (eye worm)	TK/Met protein kinase	0.015	0.241	0.2704
Echinococcus multilocularis	tensin	0.0219	0.4164	0.3484
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Trichomonas vaginalis	AGC family protein kinase	0.015	0.241	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.015	0.241	0.1985
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0369	0.793	0.793
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.015	0.241	0.241
Echinococcus multilocularis	epidermal growth factor receptor	0.015	0.241	0.1527
Echinococcus multilocularis	N chimaerin	0.0219	0.4164	0.3484
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Plasmodium falciparum	tyrosine kinase-like protein	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0369	0.793	0.793
Loa Loa (eye worm)	SH2 domain-containing protein	0.0219	0.4164	0.5022
Loa Loa (eye worm)	STAT protein	0.0219	0.4164	0.5022
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.015	0.241	0.1527
Echinococcus multilocularis	tyrosine kinase	0.015	0.241	0.1527
Echinococcus multilocularis	receptor type guanylyl cyclase	0.015	0.241	0.1527
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0219	0.4164	0.3484
Brugia malayi	hypothetical protein	0.0219	0.4164	0.4532
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Echinococcus granulosus	protein tyrosine kinase	0.015	0.241	0.241
Plasmodium falciparum	tyrosine kinase-like protein	0.015	0.241	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.015	0.241	0.2704
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0219	0.4164	0.3484
Brugia malayi	Protein kinase domain containing protein	0.0369	0.793	1
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Brugia malayi	Sex muscle abnormal protein 5	0.0219	0.4164	0.4532
Schistosoma mansoni	tyrosine protein kinase	0.015	0.241	0.1822
Echinococcus granulosus	tyrosine protein kinase shark	0.0369	0.793	0.793
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1043	0.0896
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0219	0.4164	0.4164
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0369	0.793	0.793
Echinococcus granulosus	natriuretic peptide receptor 1	0.015	0.241	0.241
Echinococcus granulosus	activated cdc42 kinase 1	0.015	0.241	0.241
Brugia malayi	integrin-linked kinase	0.015	0.241	0.1985
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Echinococcus multilocularis	FL cytokine receptor	0.015	0.241	0.1527
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.015	0.241	0.1527
Plasmodium falciparum	protein kinase, putative	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.015	0.241	0.2704
Loa Loa (eye worm)	SRC-1	0.0369	0.793	1
Brugia malayi	WGR domain containing protein	0.0174	0.301	0.2857
Echinococcus multilocularis	SH2 motif	0.0219	0.4164	0.3484
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.015	0.241	0.2704
Echinococcus granulosus	tyrosine protein kinase csk	0.015	0.241	0.241
Echinococcus multilocularis	tyrosine protein kinase shark	0.0369	0.793	0.7689
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.015	0.241	0.1527
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0219	0.4164	0.4164
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.241	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0369	0.793	0.7689
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.015	0.241	0.2704
Echinococcus granulosus	expressed conserved protein	0.0219	0.4164	0.4164
Schistosoma mansoni	growth factor receptor-bound protein	0.0219	0.4164	0.3712
Echinococcus multilocularis	protein kinase	0.015	0.241	0.1527
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0219	0.4164	0.4164
Echinococcus multilocularis	SH2 motif	0.0219	0.4164	0.3484
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.015	0.241	0.241
Echinococcus multilocularis	tyrosine protein kinase HCK	0.015	0.241	0.1527
Loa Loa (eye worm)	TK protein kinase	0.0369	0.793	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0369	0.793	0.793
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.015	0.241	0.2704
Echinococcus multilocularis	tensin	0.0219	0.4164	0.3484
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0369	0.793	1
Echinococcus granulosus	epidermal growth factor receptor	0.015	0.241	0.241
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0369	0.793	0.7689
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0219	0.4164	0.4164
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.015	0.241	0.1527
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0219	0.4164	0.3484
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.015	0.241	0.1985
Echinococcus granulosus	tyrosine kinase	0.0369	0.793	0.793
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.241	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0219	0.4164	0.4532
Trichomonas vaginalis	protein tyrosine kinase, putative	0.015	0.241	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.015	0.241	0.5
Schistosoma mansoni	tensin-related	0.0219	0.4164	0.3712
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0369	0.793	0.7689
Echinococcus multilocularis	c src tyrosine kinase	0.0369	0.793	0.7689
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Schistosoma mansoni	suppressor of cytokine signaling	0.0219	0.4164	0.3712
Echinococcus multilocularis	tyrosine kinase	0.0369	0.793	0.7689
Schistosoma mansoni	ephrin receptor	0.015	0.241	0.1822
Echinococcus granulosus	tyrosine protein kinase csk	0.015	0.241	0.241
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0369	0.793	0.793
Trypanosoma brucei	protein kinase, putative	0.015	0.241	1
Brugia malayi	Variant SH3 domain containing protein	0.0219	0.4164	0.4532
Plasmodium falciparum	protein kinase, putative	0.015	0.241	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.015	0.241	0.2704
Onchocerca volvulus		0.0219	0.4164	0.3177
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.015	0.241	0.1527
Trypanosoma brucei	Flagellum attachment zone protein 20	0.015	0.241	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0219	0.4164	0.5022
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	tyrosine kinase	0.0369	0.793	0.7769
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0369	0.793	0.793
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.015	0.241	0.241
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0369	0.793	0.793
Schistosoma mansoni	neuropeptide receptor	0.0451	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0219	0.4164	0.3484
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.241	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0369	0.793	0.7689
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Brugia malayi	SH2 domain containing protein	0.0219	0.4164	0.4532
Trypanosoma cruzi	protein kinase, putative	0.015	0.241	1
Onchocerca volvulus		0.0369	0.793	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.015	0.241	0.1985
Loa Loa (eye worm)	TK/RYK protein kinase	0.015	0.241	0.2704
Brugia malayi	Raf kinase	0.015	0.241	0.1985
Brugia malayi	SH2 domain containing protein	0.0219	0.4164	0.4532
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.241	0.1822
Brugia malayi	C-terminal src kinase protein 1	0.015	0.241	0.1985
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.241	0.1822
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.015	0.241	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0219	0.4164	0.3712
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.015	0.241	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.015	0.241	0.1985
Loa Loa (eye worm)	TK/EPH protein kinase	0.015	0.241	0.2704
Echinococcus granulosus	activin receptor type	0.015	0.241	0.241
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Plasmodium vivax	tyrosine kinase-like protein, putative	0.015	0.241	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.015	0.241	0.241
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0369	0.793	0.793
Schistosoma mansoni	tyrosine kinase	0.0369	0.793	0.7769
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.015	0.241	0.241
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Entamoeba histolytica	SH2 domain containing protein	0.0219	0.4164	0.3177
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0369	0.793	0.7689
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.015	0.241	0.1985
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Echinococcus granulosus	tyrosine protein kinase	0.015	0.241	0.241
Schistosoma mansoni	GTPase activating protein	0.0219	0.4164	0.3712
Echinococcus multilocularis	protein KINase family member (kin 25)	0.015	0.241	0.1527
Echinococcus granulosus	c src tyrosine kinase	0.0369	0.793	0.793
Brugia malayi	SH2 domain containing protein	0.0219	0.4164	0.4532
Loa Loa (eye worm)	serine/threonine protein kinase	0.015	0.241	0.2704
Schistosoma mansoni	ephrin receptor	0.015	0.241	0.1822
Loa Loa (eye worm)	TK/CSK protein kinase	0.015	0.241	0.2704
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.241	0.1822
Schistosoma mansoni	tensin-related	0.0219	0.4164	0.3712
Loa Loa (eye worm)	RGC/RGC protein kinase	0.015	0.241	0.2704
Echinococcus granulosus	retinal guanylyl cyclase 2	0.015	0.241	0.241
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0369	0.793	0.7689
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0219	0.4164	0.4532
Echinococcus granulosus	hypothetical protein	0.0219	0.4164	0.4164
Echinococcus granulosus	NCK adaptor protein	0.0219	0.4164	0.4164
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Loa Loa (eye worm)	TK/FER protein kinase	0.015	0.241	0.2704
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Schistosoma mansoni	suppressor of cytokine signaling	0.0219	0.4164	0.3712
Echinococcus granulosus	SH2 motif	0.0219	0.4164	0.4164
Loa Loa (eye worm)	TK/INSR protein kinase	0.015	0.241	0.2704
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.015	0.241	0.2704
Onchocerca volvulus		0.0219	0.4164	0.3177
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.015	0.241	0.1527
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Onchocerca volvulus		0.0369	0.793	1
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.241	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.015	0.241	0.241
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	poly adp ribose polymerase 2	0.0095	0.1043	0.1043
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.015	0.241	1
Echinococcus multilocularis		0.0219	0.4164	0.3484
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Protein kinase domain containing protein	0.0369	0.793	1
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.241	0.1985
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0219	0.4164	0.3712
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.015	0.241	0.2704
Echinococcus multilocularis	tyrosine protein kinase csk	0.015	0.241	0.1527
Echinococcus granulosus	kinase suppressor of Ras 1	0.015	0.241	0.241
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0369	0.793	0.7689
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.015	0.241	0.1985
Echinococcus multilocularis	heat shock protein 70	0.015	0.241	0.1527
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0219	0.4164	0.5022
Echinococcus multilocularis	insulin receptor	0.015	0.241	0.1527
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0369	0.793	0.7689
Echinococcus granulosus	receptor type guanylyl cyclase	0.015	0.241	0.241
Echinococcus granulosus	fibroblast growth factor receptor 4	0.015	0.241	0.241
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0219	0.4164	0.4532
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Brugia malayi	Receptor family ligand binding region containing protein	0.015	0.241	0.1985
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Giardia lamblia	Protein 21.1	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.015	0.241	0.241
Loa Loa (eye worm)	SH2 domain-containing protein	0.0219	0.4164	0.5022
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0369	0.793	0.793
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	tyrosine kinase	0.0369	0.793	0.7769
Schistosoma mansoni	growth factor receptor-bound protein	0.0219	0.4164	0.3712
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Onchocerca volvulus		0.0219	0.4164	0.3177
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.015	0.241	0.2704
Loa Loa (eye worm)	TK/ALK protein kinase	0.015	0.241	0.2704
Onchocerca volvulus		0.0369	0.793	1
Schistosoma mansoni	adapter molecule crk	0.0219	0.4164	0.3712
Loa Loa (eye worm)	TK/ACK protein kinase	0.015	0.241	0.2704
Echinococcus granulosus	N chimaerin	0.0219	0.4164	0.4164
Brugia malayi	Tensin	0.0219	0.4164	0.4532
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0369	0.793	0.793
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.015	0.241	0.1527
Onchocerca volvulus		0.0369	0.793	1
Trypanosoma brucei	Pseudokinase, putative	0.015	0.241	1
Trichomonas vaginalis	CAMK family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	serine/threonine RGC	0.015	0.241	0.1822
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.015	0.241	0.2704
Echinococcus granulosus	integrin linked protein kinase	0.015	0.241	0.241
Loa Loa (eye worm)	TK/FER protein kinase	0.015	0.241	0.2704
Echinococcus multilocularis	tyrosine protein kinase csk	0.015	0.241	0.1527
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Schistosoma mansoni	hypothetical protein	0.015	0.241	0.1822
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0369	0.793	0.7689
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.015	0.241	0.1527
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Protein kinase domain containing protein	0.0369	0.793	1
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0219	0.4164	0.4164
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.015	0.241	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0369	0.793	0.7689
Echinococcus granulosus	SH2 motif	0.0219	0.4164	0.4164
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0219	0.4164	0.3712
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Onchocerca volvulus		0.0219	0.4164	0.3177
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Brugia malayi	SH2 domain containing protein	0.0219	0.4164	0.4532
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.015	0.241	0.241
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0219	0.4164	0.3177
Echinococcus multilocularis	protein kinase	0.015	0.241	0.1527
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Loa Loa (eye worm)	TK/DDR protein kinase	0.015	0.241	0.2704
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Brugia malayi	ephrin receptor 1 precursor	0.015	0.241	0.1985
Brugia malayi	hypothetical protein	0.015	0.241	0.1985
Schistosoma mansoni	signal transduction protein lnk-related	0.0219	0.4164	0.3712
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0219	0.4164	0.3177
Brugia malayi	SH2 domain containing protein	0.0369	0.793	1
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Echinococcus multilocularis	kinase suppressor of Ras 1	0.015	0.241	0.1527
Trichomonas vaginalis	protein kinase atn1, putative	0.015	0.241	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0219	0.4164	0.4164
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0369	0.793	0.7689
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.015	0.241	0.241
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.015	0.241	0.241
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0174	0.301	0.2469
Echinococcus multilocularis	neuropeptide receptor	0.0451	1	1
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus granulosus	tyrosine kinase	0.0369	0.793	0.793
Trypanosoma cruzi	protein kinase, putative	0.015	0.241	1
Schistosoma mansoni	SH2A	0.0219	0.4164	0.3712
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Giardia lamblia	Kinase	0.015	0.241	0.5
Onchocerca volvulus		0.0369	0.793	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0369	0.793	0.7689
Echinococcus multilocularis	epidermal growth factor receptor	0.015	0.241	0.1527
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0219	0.4164	0.4532
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Leishmania major	hypothetical protein, conserved	0.015	0.241	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0219	0.4164	0.5022
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0219	0.4164	0.4164
Echinococcus granulosus	SHC transforming protein 3	0.0219	0.4164	0.4164
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0095	0.1043	0.0349
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0219	0.4164	0.4532
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0369	0.793	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.015	0.241	0.1527
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0369	0.793	0.7689
Echinococcus multilocularis	tyrosine protein kinase csk	0.015	0.241	0.1527
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.015	0.241	1
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.015	0.241	0.1527
Brugia malayi	Protein kinase domain containing protein	0.0369	0.793	1
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.018	0.3181	1
Leishmania major	protein kinase, putative	0.015	0.241	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.015	0.241	0.241
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.015	0.241	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.015	0.241	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0219	0.4164	0.5022
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Brugia malayi	Tyrosine-protein kinase PR2	0.015	0.241	0.1985
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0219	0.4164	0.4164
Onchocerca volvulus		0.0369	0.793	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.015	0.241	0.2704
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.015	0.241	0.1527
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.015	0.241	0.1822
Loa Loa (eye worm)	RGC/RGC protein kinase	0.015	0.241	0.2704
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Loa Loa (eye worm)	TK/FER protein kinase	0.015	0.241	0.2704
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.015	0.241	0.1985
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.015	0.241	0.1527
Echinococcus granulosus	activated cdc42 kinase 1	0.015	0.241	0.241
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.015	0.241	0.1527
Brugia malayi	SH2 domain containing protein	0.0369	0.793	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.015	0.241	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.015	0.241	0.241
Echinococcus granulosus	tyrosine protein kinase Blk	0.0369	0.793	0.793
Loa Loa (eye worm)	SH2 domain-containing protein	0.0219	0.4164	0.5022
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Schistosoma mansoni	shc transforming protein	0.0219	0.4164	0.3712
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Echinococcus multilocularis	activated cdc42 kinase 1	0.015	0.241	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.015	0.241	0.1822
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0219	0.4164	0.4164
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Loa Loa (eye worm)	TK/FER protein kinase	0.015	0.241	0.2704
Schistosoma mansoni	hypothetical protein	0.0219	0.4164	0.3712
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.015	0.241	0.1527
Brugia malayi	SH2 domain containing protein	0.0219	0.4164	0.4532
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Schistosoma mansoni	tensin	0.0219	0.4164	0.3712
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0369	0.793	1
Onchocerca volvulus		0.0219	0.4164	0.3177
Plasmodium vivax	protein kinase, putative	0.015	0.241	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.015	0.241	0.2704
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0174	0.301	0.1087
Echinococcus granulosus	tensin	0.0219	0.4164	0.4164
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0174	0.301	0.2196
Echinococcus multilocularis	signal transduction protein lnk realted	0.0219	0.4164	0.3484
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	protein kinase	0.015	0.241	0.1822
Echinococcus multilocularis	protein tyrosine kinase	0.015	0.241	0.1527
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0219	0.4164	0.3484
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Brugia malayi	SH2 domain containing protein	0.0219	0.4164	0.4532
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0219	0.4164	0.3712
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.015	0.241	0.1822
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0369	0.793	0.793
Echinococcus multilocularis	activin receptor type	0.015	0.241	0.1527
Schistosoma mansoni	protein tyrosine kinase	0.015	0.241	0.1822
Schistosoma mansoni	vav2	0.0219	0.4164	0.3712
Schistosoma mansoni	nck2/grb4	0.0219	0.4164	0.3712
Loa Loa (eye worm)	TK protein kinase	0.015	0.241	0.2704
Echinococcus multilocularis	SHC transforming protein 3	0.0219	0.4164	0.3484
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	RhoGAP domain containing protein	0.0219	0.4164	0.4532
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.015	0.241	0.1527
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Leishmania major	protein kinase, putative	0.015	0.241	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0369	0.793	0.7769
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Giardia lamblia	Kinase, NEK	0.015	0.241	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0219	0.4164	0.3712
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.015	0.241	0.1527
Echinococcus multilocularis	tyrosine protein kinase csk	0.015	0.241	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1967	0.2119
Brugia malayi	SH2 domain containing protein	0.0219	0.4164	0.4532
Loa Loa (eye worm)	TK/FER protein kinase	0.015	0.241	0.2704
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0369	0.793	0.7689
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.015	0.241	0.241
Echinococcus granulosus	retinal guanylyl cyclase 2	0.015	0.241	0.241
Echinococcus multilocularis	NCK adaptor protein	0.0219	0.4164	0.3484
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0219	0.4164	0.3484
Schistosoma mansoni	tyrosine kinase	0.0369	0.793	0.7769
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Loa Loa (eye worm)	hypothetical protein	0.0219	0.4164	0.5022
Brugia malayi	Immunoglobulin I-set domain containing protein	0.015	0.241	0.1985
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0219	0.4164	0.4532
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.015	0.241	0.1822
Loa Loa (eye worm)	TK/FER protein kinase	0.015	0.241	0.2704
Brugia malayi	Protein kinase domain containing protein	0.015	0.241	0.1985
Loa Loa (eye worm)	TK/ROR protein kinase	0.015	0.241	0.2704
Brugia malayi	hypothetical protein	0.0369	0.793	1
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0219	0.4164	0.3484
Schistosoma mansoni	tensin	0.0219	0.4164	0.3712
Echinococcus multilocularis	G protein coupled receptor 139	0.0451	1	1
Onchocerca volvulus		0.0219	0.4164	0.3177
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.015	0.241	0.1985
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.015	0.241	0.241
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0219	0.4164	0.4164
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.015	0.241	0.241
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0219	0.4164	0.4164
Schistosoma mansoni	tyrosine kinase	0.015	0.241	0.1822
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.015	0.241	0.1527
Loa Loa (eye worm)	RGC/RGC protein kinase	0.015	0.241	0.2704
Trichomonas vaginalis	TKL family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0174	0.301	0.301
Brugia malayi	Variant SH3 domain containing protein	0.0219	0.4164	0.4532
Brugia malayi	SRC-1	0.0369	0.793	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0369	0.793	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0369	0.793	0.793
Echinococcus multilocularis	transfer RNA-Thr	0.015	0.241	0.1527
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0219	0.4164	0.3484
Schistosoma mansoni	tyrosine kinase	0.0369	0.793	0.7769
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0369	0.793	0.793
Schistosoma mansoni	serine/threonine protein kinase	0.015	0.241	0.1822
Loa Loa (eye worm)	hypothetical protein	0.015	0.241	0.2704
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0219	0.4164	0.3484
Brugia malayi	protein-tyrosine kinase	0.0369	0.793	1
Echinococcus granulosus	protein kinase	0.015	0.241	0.241
Trichomonas vaginalis	STE family protein kinase	0.015	0.241	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0369	0.793	1
Trichomonas vaginalis	TK family protein kinase	0.015	0.241	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.015	0.241	0.241

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 23.1 %	Inhibition of PARP1 (unknown origin) at 1 uM	ChEMBL.	23481647

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2347908

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1754014