Detailed information for compound 1754611

Basic information

Technical information
  • TDR Targets ID: 1754611
  • Name: 7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino] -5-[(1R)-1-phenylethyl]sulfanyl-3H-[1,3]thiaz olo[5,4-e]pyrimidin-2-one
  • MW: 404.549 | Formula: C19H24N4O2S2
  • H donors: 3 H acceptors: 4 LogP: 4.42 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](Nc1nc(S[C@@H](c2ccccc2)C)nc2c1sc(=O)[nH]2)CC(C)C
  • InChi: 1S/C19H24N4O2S2/c1-11(2)9-14(10-24)20-16-15-17(23-19(25)27-15)22-18(21-16)26-12(3)13-7-5-4-6-8-13/h4-8,11-12,14,24H,9-10H2,1-3H3,(H2,20,21,22,23,25)/t12-,14-/m1/s1
  • InChiKey: IAGWEZFSRRPOSS-TZMCWYRMSA-N  

Network

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Synonyms

  • 7-[[(1R)-1-(hydroxymethyl)-3-methyl-butyl]amino]-5-[(1R)-1-phenylethyl]sulfanyl-3H-thiazolo[5,4-e]pyrimidin-2-one
  • 7-[[(1R)-1-(hydroxymethyl)-3-methylbutyl]amino]-5-[[(1R)-1-phenylethyl]thio]-3H-thiazolo[5,4-e]pyrimidin-2-one
  • 7-[[(1R)-3-methyl-1-methylol-butyl]amino]-5-[[(1R)-1-phenylethyl]thio]-3H-thiazolo[5,4-e]pyrimidin-2-one
  • 7-[[(2R)-1-hydroxy-4-methyl-pentan-2-yl]amino]-5-[(1R)-1-phenylethyl]sulfanyl-3H-[1,3]thiazolo[5,4-e]pyrimidin-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-X3-C motif) receptor 1 Starlite/ChEMBL References
Homo sapiens chemokine (C-X-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis ephrin type A receptor 4 A 0.0306 0.1926 0.1926
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus granulosus suppressor of cytokine signaling 6 0.0451 0.4527 0.4527
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0306 0.1926 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1926 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0306 0.1926 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0451 0.4527 0.3222
Echinococcus multilocularis tensin 0.0451 0.4527 0.4527
Giardia lamblia Kinase, NEK 0.0306 0.1926 0.5
Trypanosoma brucei Pseudokinase, putative 0.0306 0.1926 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0306 0.1926 0.1926
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0306 0.1926 0.5
Brugia malayi SRC-1 0.0757 1 1
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0757 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0451 0.4527 0.4527
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus granulosus SH2 domain containing adapter protein F 0.0451 0.4527 0.4527
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0306 0.1926 0.1926
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0306 0.1926 0.1926
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0451 0.4527 0.4527
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Brugia malayi RhoGAP domain containing protein 0.0451 0.4527 0.3222
Toxoplasma gondii protein kinase 0.0306 0.1926 0.5
Plasmodium vivax protein kinase, putative 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0306 0.1926 0.5
Echinococcus multilocularis activin receptor type 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni shc transforming protein 0.0451 0.4527 0.4527
Brugia malayi SH2 domain containing protein 0.0757 1 1
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus multilocularis tyrosine protein kinase shark 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0757 1 1
Schistosoma mansoni tensin 0.0451 0.4527 0.4527
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0451 0.4527 0.4527
Plasmodium falciparum tyrosine kinase-like protein 0.0306 0.1926 0.5
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0306 0.1926 0.1926
Echinococcus multilocularis tyrosine protein kinase Srms 0.0757 1 1
Echinococcus granulosus tensin 0.0451 0.4527 0.4527
Loa Loa (eye worm) TK protein kinase 0.0757 1 1
Schistosoma mansoni GTPase activating protein 0.0451 0.4527 0.4527
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0306 0.1926 0.1926
Echinococcus multilocularis activated cdc42 kinase 1 0.0306 0.1926 0.1926
Echinococcus granulosus retinal guanylyl cyclase 2 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0757 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0306 0.1926 0.1926
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0451 0.4527 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0451 0.4527 0.3222
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0306 0.1926 0.1926
Echinococcus granulosus epidermal growth factor receptor 0.0306 0.1926 0.1926
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0451 0.4527 0.3222
Schistosoma mansoni protein tyrosine kinase 0.0306 0.1926 0.1926
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0306 0.1926 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0757 1 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0451 0.4527 0.3222
Plasmodium falciparum tyrosine kinase-like protein 0.0306 0.1926 0.5
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0451 0.4527 0.4527
Entamoeba histolytica hypothetical protein 0.0307 0.1947 0.0026
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0306 0.1926 0.1926
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0451 0.4527 0.4527
Loa Loa (eye worm) hypothetical protein 0.0757 1 1
Echinococcus granulosus NCK adaptor protein 0.0451 0.4527 0.4527
Echinococcus granulosus SH2 motif 0.0451 0.4527 0.4527
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Leishmania major protein kinase, putative 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0451 0.4527 0.3222
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1926 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0757 1 1
Echinococcus granulosus tyrosine protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0306 0.1926 0.5
Brugia malayi STAT protein, DNA binding domain containing protein 0.0451 0.4527 0.3222
Brugia malayi SH2 domain containing protein 0.0451 0.4527 0.3222
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.1926 0.5
Plasmodium falciparum protein kinase, putative 0.0306 0.1926 0.5
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0306 0.1926 0.1926
Loa Loa (eye worm) TK/ABL protein kinase 0.0757 1 1
Brugia malayi SH2 domain containing protein 0.0451 0.4527 0.3222
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0451 0.4527 0.4527
Brugia malayi hypothetical protein 0.0757 1 1
Echinococcus granulosus integrin linked protein kinase 0.0306 0.1926 0.1926
Echinococcus granulosus tyrosine protein kinase Fyn 0.0757 1 1
Echinococcus multilocularis tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus granulosus protein tyrosine kinase 0.0306 0.1926 0.1926
Schistosoma mansoni suppressor of cytokine signaling 0.0451 0.4527 0.4527
Schistosoma mansoni tyrosine kinase 0.0757 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0306 0.1926 0.1926
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0451 0.4527 0.4527
Echinococcus granulosus epidermal growth factor receptor 0.0306 0.1926 0.1926
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0306 0.1926 0.5
Brugia malayi hypothetical protein 0.0451 0.4527 0.3222
Schistosoma mansoni hypothetical protein 0.0306 0.1926 0.1926
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0306 0.1926 0.1926
Echinococcus granulosus insulin receptor 0.0306 0.1926 0.1926
Echinococcus multilocularis tyrosine protein kinase HCK 0.0306 0.1926 0.1926
Entamoeba histolytica hypothetical protein 0.0307 0.1947 0.0026
Brugia malayi Sex muscle abnormal protein 5 0.0451 0.4527 0.3222
Loa Loa (eye worm) SH2 domain-containing protein 0.0451 0.4527 0.3222
Schistosoma mansoni SH2A 0.0451 0.4527 0.4527
Echinococcus granulosus tyrosine protein kinase Srms 0.0757 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0306 0.1926 0.1926
Echinococcus granulosus signal transduction protein lnk realted 0.0451 0.4527 0.4527
Echinococcus granulosus SHC transforming protein 3 0.0451 0.4527 0.4527
Echinococcus granulosus c src tyrosine kinase 0.0757 1 1
Echinococcus multilocularis 0.0451 0.4527 0.4527
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0306 0.1926 0.1926
Echinococcus multilocularis SHC transforming protein 3 0.0451 0.4527 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Onchocerca volvulus 0.0451 0.4527 0.3222
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0451 0.4527 0.3222
Entamoeba histolytica hypothetical protein 0.0307 0.1947 0.0026
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0306 0.1926 0.1926
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0306 0.1926 0.1926
Loa Loa (eye worm) SRC-1 0.0757 1 1
Trypanosoma cruzi protein kinase, putative 0.0306 0.1926 0.5
Trichomonas vaginalis AGC family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis protein tyrosine kinase, putative 0.0306 0.1926 0.5
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0306 0.1926 0.1926
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0306 0.1926 0.5
Echinococcus granulosus suppressor of cytokine signaling 7 0.0451 0.4527 0.4527
Echinococcus granulosus tyrosine protein kinase Fyn 0.0757 1 1
Echinococcus granulosus SH2 domain containing protein 7 0.0451 0.4527 0.4527
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0757 1 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus granulosus kinase suppressor of Ras 1 0.0306 0.1926 0.1926
Plasmodium falciparum protein kinase, putative 0.0306 0.1926 0.5
Echinococcus multilocularis NCK adaptor protein 0.0451 0.4527 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Brugia malayi SH2 domain containing protein 0.0757 1 1
Loa Loa (eye worm) STAT protein 0.0451 0.4527 0.3222
Echinococcus granulosus tyrosine kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Brugia malayi SH2 domain containing protein 0.0451 0.4527 0.3222
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0306 0.1926 0.1926
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0451 0.4527 0.4527
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0451 0.4527 0.3222
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0451 0.4527 0.4527
Echinococcus multilocularis integrin linked protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0306 0.1926 0.1926
Echinococcus granulosus tyrosine protein kinase Blk 0.0757 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0757 1 1
Trypanosoma brucei protein kinase, putative 0.0306 0.1926 0.5
Onchocerca volvulus 0.0757 1 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0451 0.4527 0.3222
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0451 0.4527 0.4527
Schistosoma mansoni tyrosine kinase 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis transfer RNA-Thr 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Onchocerca volvulus 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni serine/threonine RGC 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0306 0.1926 0.1926
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0757 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Onchocerca volvulus 0.0757 1 1
Onchocerca volvulus 0.0757 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0757 1 1
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Onchocerca volvulus 0.0757 1 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0306 0.1926 0.1926
Trichomonas vaginalis STE family protein kinase 0.0306 0.1926 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0451 0.4527 0.3222
Echinococcus multilocularis protein KINase family member (kin 25) 0.0306 0.1926 0.1926
Echinococcus granulosus hypothetical protein 0.0451 0.4527 0.4527
Echinococcus granulosus tyrosine protein kinase pr2 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0306 0.1926 0.1926
Echinococcus multilocularis heat shock protein 70 0.0306 0.1926 0.1926
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0757 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0451 0.4527 0.4527
Schistosoma mansoni hypothetical protein 0.0336 0.247 0.247
Brugia malayi Protein kinase domain containing protein 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0757 1 1
Echinococcus granulosus SH2 motif 0.0451 0.4527 0.4527
Echinococcus granulosus tyrosine protein kinase Lyn 0.0757 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0451 0.4527 0.4527
Giardia lamblia Kinase, NEK 0.0306 0.1926 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0451 0.4527 0.3222
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0451 0.4527 0.4527
Onchocerca volvulus 0.0757 1 1
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni signal transduction protein lnk-related 0.0451 0.4527 0.4527
Schistosoma mansoni tyrosine kinase 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Brugia malayi tRNA modification GTPase TrmE family protein 0.0451 0.4527 0.3222
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Echinococcus multilocularis protein kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni hypothetical protein 0.0451 0.4527 0.4527
Plasmodium vivax tyrosine kinase-like protein, putative 0.0306 0.1926 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0451 0.4527 0.4527
Echinococcus multilocularis epidermal growth factor receptor 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase pr2 0.0306 0.1926 0.1926
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Schistosoma mansoni nck2/grb4 0.0451 0.4527 0.4527
Entamoeba histolytica protein kinase, putative 0.0451 0.4527 0.3222
Entamoeba histolytica SH2 domain containing protein 0.0451 0.4527 0.3222
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0757 1 1
Entamoeba histolytica protein kinase, putative 0.0307 0.1947 0.0026
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Leishmania major hypothetical protein, conserved 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0757 1 1
Brugia malayi Variant SH3 domain containing protein 0.0451 0.4527 0.3222
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Brugia malayi Tensin 0.0451 0.4527 0.3222
Schistosoma mansoni growth factor receptor-bound protein 0.0451 0.4527 0.4527
Echinococcus granulosus tyrosine protein kinase HCK 0.0306 0.1926 0.1926
Echinococcus granulosus retinal guanylyl cyclase 2 0.0306 0.1926 0.1926
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.1926 0.1926
Echinococcus granulosus tyrosine protein kinase csk 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Brugia malayi SH2 domain containing protein 0.0451 0.4527 0.3222
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0757 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0451 0.4527 0.4527
Echinococcus granulosus tyrosine kinase 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni tensin-related 0.0451 0.4527 0.4527
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0306 0.1926 0.1926
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1926 0.5
Echinococcus multilocularis protein tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus granulosus natriuretic peptide receptor 1 0.0306 0.1926 0.1926
Echinococcus granulosus N chimaerin 0.0451 0.4527 0.4527
Leishmania major protein kinase, putative 0.0306 0.1926 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Schistosoma mansoni adapter molecule crk 0.0451 0.4527 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0307 0.1947 0.0026
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0306 0.1926 0.1926
Onchocerca volvulus 0.0451 0.4527 0.3222
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0757 1 1
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Echinococcus multilocularis signal transduction protein lnk realted 0.0451 0.4527 0.4527
Echinococcus granulosus activin receptor type 0.0306 0.1926 0.1926
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0451 0.4527 0.3222
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni vav2 0.0451 0.4527 0.4527
Schistosoma mansoni ephrin receptor 0.0306 0.1926 0.1926
Echinococcus multilocularis N chimaerin 0.0451 0.4527 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1926 0.5
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0306 0.1926 0.1926
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0451 0.4527 0.4527
Echinococcus granulosus ephrin type A receptor 4 A 0.0306 0.1926 0.1926
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.0353 0.0353
Brugia malayi SH2 domain containing protein 0.0451 0.4527 0.3222
Schistosoma mansoni tensin-related 0.0451 0.4527 0.4527
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1926 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0757 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0306 0.1926 0.1926
Echinococcus multilocularis growth factor receptor bound protein 2 0.0451 0.4527 0.4527
Schistosoma mansoni growth factor receptor-bound protein 0.0451 0.4527 0.4527
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus multilocularis tensin 0.0451 0.4527 0.4527
Brugia malayi Variant SH3 domain containing protein 0.0451 0.4527 0.3222
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0451 0.4527 0.4527
Echinococcus granulosus activated cdc42 kinase 1 0.0306 0.1926 0.1926
Echinococcus multilocularis c src tyrosine kinase 0.0757 1 1
Onchocerca volvulus 0.0451 0.4527 0.3222
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0757 1 1
Schistosoma mansoni tyrosine protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0757 1 1
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Echinococcus multilocularis insulin receptor 0.0306 0.1926 0.1926
Brugia malayi SH2 domain containing protein 0.0451 0.4527 0.3222
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0306 0.1926 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0306 0.1926 0.1926
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0451 0.4527 0.4527
Schistosoma mansoni tensin 0.0451 0.4527 0.4527
Echinococcus granulosus growth factor receptor bound protein 2 0.0451 0.4527 0.4527
Giardia lamblia Kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0306 0.1926 0.1926
Echinococcus multilocularis SH2 motif 0.0451 0.4527 0.4527
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0451 0.4527 0.4527
Echinococcus multilocularis raf serine:threonine protein kinase 0.0306 0.1926 0.1926
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Echinococcus multilocularis tyrosine protein kinase Abl 0.0757 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0306 0.1926 0.1926
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0451 0.4527 0.3222
Trypanosoma cruzi protein kinase, putative 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine kinase 0.0757 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.1926 0.1926
Onchocerca volvulus 0.0451 0.4527 0.3222
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus multilocularis SH2 motif 0.0451 0.4527 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Giardia lamblia Protein 21.1 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0757 1 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Trichomonas vaginalis TK family protein kinase 0.0306 0.1926 0.5
Toxoplasma gondii STE kinase 0.0306 0.1926 0.5
Brugia malayi Variant SH3 domain containing protein 0.0451 0.4527 0.3222
Brugia malayi protein-tyrosine kinase 0.0757 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0757 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Onchocerca volvulus 0.0451 0.4527 0.3222
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Schistosoma mansoni tyrosine kinase 0.0757 1 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0306 0.1926 0.1926
Trichomonas vaginalis protein kinase atn1, putative 0.0306 0.1926 0.5
Schistosoma mansoni tensin 0.0451 0.4527 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Brugia malayi Protein kinase domain containing protein 0.0757 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Echinococcus multilocularis SH2 motif 0.0451 0.4527 0.4527
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0757 1 1
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0757 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0757 1 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Brugia malayi Protein kinase domain containing protein 0.0757 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0757 1 1
Plasmodium falciparum protein kinase, putative 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0306 0.1926 0.1926
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0451 0.4527 0.3222
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Brugia malayi SH2 domain containing protein 0.0451 0.4527 0.3222
Echinococcus granulosus tyrosine kinase 0.0757 1 1
Echinococcus granulosus expressed conserved protein 0.0451 0.4527 0.4527
Echinococcus granulosus protein kinase 0.0306 0.1926 0.1926
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0757 1 1
Brugia malayi Variant SH3 domain containing protein 0.0451 0.4527 0.3222
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.1926 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0306 0.1926 0.1926
Echinococcus granulosus retinal guanylyl cyclase 2 0.0306 0.1926 0.1926
Echinococcus granulosus tyrosine protein kinase ABL1 0.0757 1 1
Onchocerca volvulus 0.0451 0.4527 0.3222
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0306 0.1926 0.1926
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis FL cytokine receptor 0.0306 0.1926 0.1926
Echinococcus granulosus tyrosine protein kinase csk 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Brugia malayi Protein kinase domain containing protein 0.0757 1 1
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Loa Loa (eye worm) hypothetical protein 0.0451 0.4527 0.3222
Toxoplasma gondii protein kinase domain-containing protein 0.0306 0.1926 0.5
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis SH2 domain containing protein 7 0.0451 0.4527 0.4527
Echinococcus multilocularis protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni hypothetical protein 0.0451 0.4527 0.4527
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0757 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0451 0.4527 0.4527
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926
Schistosoma mansoni tyrosine kinase 0.0306 0.1926 0.1926
Echinococcus granulosus tyrosine protein kinase shark 0.0757 1 1
Trichomonas vaginalis TKL family protein kinase 0.0306 0.1926 0.5
Echinococcus multilocularis kinase suppressor of Ras 1 0.0306 0.1926 0.1926
Schistosoma mansoni ephrin receptor 0.0306 0.1926 0.1926
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0306 0.1926 0.1926
Schistosoma mansoni protein kinase 0.0306 0.1926 0.1926

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 8 nM Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis ChEMBL. 23516963
Ki (binding) = 1360 nM Displacement of [125I]-IL8 from human CXCR2 transfected in HEK293 cells after 4 hrs by microbeta counting analysis ChEMBL. 23516963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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