Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.0704 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1367 | 0.2644 | 1 |
Echinococcus granulosus | cdgsh iron sulfur domain containing protein | 0.0244 | 0.0372 | 0.504 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1367 | 0.2644 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0034 | 0.0031 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0034 | 0.0031 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0034 | 0.0031 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1367 | 0.2644 | 1 |
Entamoeba histolytica | DNA-directed DNA polymerase, putative | 0.0066 | 0.0012 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0034 | 0.3825 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0089 | 1 |
Toxoplasma gondii | 5'-3' exonuclease, N-terminal resolvase family domain-containing protein | 0.0079 | 0.0039 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.0258 | 0.0401 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1367 | 0.2644 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0034 | 0.0845 |
Leishmania major | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0161 | 0.0205 | 0.0732 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0226 | 0.0337 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0034 | 0.0845 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1367 | 0.2644 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.0704 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1367 | 0.2644 | 1 |
Trichomonas vaginalis | DNA polymerase I, putative | 0.0066 | 0.0012 | 0.5 |
Brugia malayi | Uncharacterized hematopoietic stem/progenitor cells protein MDS029 | 0.0104 | 0.0089 | 0.0106 |
Chlamydia trachomatis | DNA polymerase I | 0.0226 | 0.0337 | 0.5 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0161 | 0.0205 | 0.0732 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0226 | 0.0337 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0034 | 0.0845 |
Schistosoma mansoni | DNA polymerase I | 0.0066 | 0.0012 | 0.0294 |
Schistosoma mansoni | CDGSH-type Zn finger-containing protein-like protein | 0.0258 | 0.0401 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0034 | 0.0845 |
Onchocerca volvulus | 0.0104 | 0.0089 | 0.0089 | |
Plasmodium falciparum | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.0161 | 0.0205 | 0.0732 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0161 | 0.0205 | 0.0732 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0034 | 0.0845 |
Giardia lamblia | Telomerase catalytic subunit | 0.1367 | 0.2644 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0034 | 0.3825 |
Brugia malayi | Telomerase reverse transcriptase | 0.3638 | 0.7236 | 1 |
Plasmodium vivax | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.0161 | 0.0205 | 0.0732 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0226 | 0.0337 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0034 | 0.3825 |
Echinococcus multilocularis | cdgsh iron sulfur domain containing protein | 0.0244 | 0.0372 | 0.504 |
Mycobacterium ulcerans | DNA polymerase I | 0.0226 | 0.0337 | 1 |
Treponema pallidum | DNA polymerase I (polA) | 0.0226 | 0.0337 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1367 | 0.2644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0012 | 0.1333 |
Trypanosoma brucei | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.0161 | 0.0205 | 0.0732 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.