Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0166 | 0.748 | 0.748 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0.1859 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 1 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.015 | 0.6542 | 0.6542 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.007 | 0.1859 | 0.2841 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0166 | 0.748 | 0.748 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.015 | 0.6542 | 0.6542 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.015 | 0.6542 | 0.6542 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0887 | 0.0887 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0039 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.015 | 0.6542 | 0.8746 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.007 | 0.1859 | 0.2841 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.015 | 0.6542 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.015 | 0.6542 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.007 | 0.1859 | 0.2841 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.0966 | 0.0966 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.0966 | 0.0966 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0166 | 0.748 | 0.748 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.007 | 0.1859 | 0.1859 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0039 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.015 | 0.6542 | 1 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0887 | 0.0887 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.015 | 0.6542 | 0.6542 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.1859 | 0.1859 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.748 | 0.748 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0166 | 0.748 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.015 | 0.6542 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.015 | 0.6542 | 0.6542 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.015 | 0.6542 | 0.8746 |
Leishmania major | silent information regulator 2, putative | 0.015 | 0.6542 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.007 | 0.1859 | 0.1859 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.5216 | 0.5216 |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.007 | 0.1859 | 0.1859 |
Loa Loa (eye worm) | transcriptional regulator | 0.015 | 0.6542 | 0.6542 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0166 | 0.748 | 0.748 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.007 | 0.1859 | 0.2841 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0166 | 0.748 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.015 | 0.6542 | 0.6542 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0166 | 0.748 | 1 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.015 | 0.6542 | 0.6542 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.015 | 0.6542 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0166 | 0.748 | 1 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.015 | 0.6542 | 0.8746 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.007 | 0.1859 | 0.2841 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.015 | 0.6542 | 0.6542 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0166 | 0.748 | 1 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15.5 nM | Inhibition of human DPP4 using Gly-Pro-AMC as substrate treated with enzyme 10 mins prior to substrate addition measured after 10 mins | ChEMBL. | 23434133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.