Detailed information for compound 1757439

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.385 | Formula: C17H24N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)C1(C)CCN1C(=O)Cc1ccc(cc1)C(C)C
  • InChi: 1S/C17H24N2O2/c1-12(2)14-7-5-13(6-8-14)11-15(20)19-10-9-17(19,3)16(21)18-4/h5-8,12H,9-11H2,1-4H3,(H,18,21)
  • InChiKey: JRDMGABMQCLEIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis abcb9, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis ABC transporter, putative 0.0173 0.0186 0.2066
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0173 0.0186 0.0184
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0897 0.1308 0.1308
Brugia malayi multidrug resistance related protein 1 0.0054 0.0001 0.0001
Brugia malayi multidrug resistance protein 3 0.0173 0.0186 0.0186
Echinococcus granulosus multidrug resistance protein 1 0.0173 0.0186 0.0184
Echinococcus granulosus carbonic anhydrase 0.0405 0.0544 0.0543
Loa Loa (eye worm) hypothetical protein 0.0054 0.0001 0.0001
Echinococcus granulosus carbonic anhydrase II 0.0897 0.1308 0.1307
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0121 0.0104 0.1158
Echinococcus granulosus multidrug resistance protein 1 0.0173 0.0186 0.0184
Entamoeba histolytica P-glycoprotein-2, putative 0.0173 0.0186 0.0848
Entamoeba histolytica P-glycoprotein 5, putative 0.0173 0.0186 0.0848
Brugia malayi ABC transporter family protein 0.0054 0.0001 0.0001
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0173 0.0186 0.0184
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0054 0.0001 0.0008
Trichomonas vaginalis ABC transporter, putative 0.0173 0.0186 0.2066
Giardia lamblia Multidrug resistance-associated protein 1 0.0054 0.0001 0.5
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0054 0.0001 0.0005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0173 0.0186 0.0184
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0173 0.0186 0.2066
Mycobacterium ulcerans carbonic anhydrase 0.1458 0.2177 1
Schistosoma mansoni carbonic anhydrase 0.0405 0.0544 0.0543
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0405 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0171 0.0183 0.0183
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.6506 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0173 0.0186 0.0184
Echinococcus granulosus multidrug resistance protein 1 0.0121 0.0104 0.0103
Echinococcus multilocularis carbonic anhydrase II 0.0897 0.1308 0.1307
Plasmodium falciparum carbonic anhydrase 0.0405 0.0544 1
Entamoeba histolytica P-glycoprotein-2 0.0173 0.0186 0.0848
Schistosoma mansoni carbonic anhydrase-related 0.0405 0.0544 0.0543
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0173 0.0186 0.2066
Echinococcus granulosus multidrug resistance protein 1 0.0173 0.0186 0.0184
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0173 0.0186 0.2066
Entamoeba histolytica P-glycoprotein-5 0.0173 0.0186 0.0848
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0173 0.0186 0.1539
Loa Loa (eye worm) IKK protein kinase 0.604 0.9278 0.9278
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0173 0.0186 0.0184
Loa Loa (eye worm) hypothetical protein 0.0405 0.0544 0.0544
Loa Loa (eye worm) ABC transporter 0.0054 0.0001 0.0001
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0897 0.1308 1
Brugia malayi ABC transporter family protein 0.0054 0.0001 0.0001
Echinococcus multilocularis multidrug resistance protein 1 0.0173 0.0186 0.0184
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0054 0.0001 0.0005
Brugia malayi ABC transporter 0.0054 0.0001 0.0001
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0405 0.0544 0.0544
Entamoeba histolytica P-glycoprotein-2 0.0173 0.0186 0.0848
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0171 0.0183 0.0182
Brugia malayi P-glycoprotein-like protein 0.0054 0.0001 0.0001
Schistosoma mansoni smdr2 0.0173 0.0186 0.0184
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0173 0.0186 0.2066
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0054 0.0001 0.0005
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0173 0.0186 0.2066
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0054 0.0001 0.0008
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0405 0.0544 0.0544
Schistosoma mansoni hypothetical protein 0.0405 0.0544 0.0543
Schistosoma mansoni carbonic anhydrase 0.1458 0.2177 0.2176
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis taga, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0173 0.0186 0.2066
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0173 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0173 0.0186 0.0186
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0054 0.0001 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.0121 0.0104 0.0103
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0054 0.0001 0.0008
Leishmania major p-glycoprotein e 0.0054 0.0001 0.0005
Loa Loa (eye worm) ABC transporter 0.0054 0.0001 0.0001
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis conserved hypothetical protein 0.063 0.0894 1
Loa Loa (eye worm) hypothetical protein 0.0447 0.061 0.061
Giardia lamblia MRP-like ABC transporter 0.0054 0.0001 0.5
Giardia lamblia ABC transporter, putative 0.0054 0.0001 0.5
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0173 0.0186 0.0852
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0173 0.0186 0.2066
Entamoeba histolytica P-glyco protein 6, putative 0.0173 0.0186 0.0848
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0054 0.0001 0.0005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0173 0.0186 0.0184
Onchocerca volvulus 0.604 0.9278 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0405 0.0544 0.0544
Schistosoma mansoni carbonic anhydrase-related 0.0405 0.0544 0.0543
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0897 0.1308 0.1307
Trypanosoma brucei multidrug resistance protein E 0.0054 0.0001 0.0008
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0173 0.0186 0.2066
Toxoplasma gondii hypothetical protein 0.0405 0.0544 1
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.6506 1 1
Brugia malayi Cytochrome P450 family protein 0.0113 0.0092 0.0092
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0173 0.0186 0.2066
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0173 0.0186 0.0184
Loa Loa (eye worm) carbonic anhydrase 3 0.0897 0.1308 0.1308
Plasmodium vivax multidrug resistance protein 1, putative 0.0173 0.0186 1
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0897 0.1308 0.1308
Schistosoma mansoni multidrug resistance protein 0.0173 0.0186 0.0184
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0173 0.0186 0.2066
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0054 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0054 0.0001 0.0001
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0828 0.1199 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0173 0.0186 0.3398
Leishmania major p-glycoprotein 0.0173 0.0186 0.0852
Entamoeba histolytica carbonic anhydrase, putative 0.1458 0.2177 1
Loa Loa (eye worm) hypothetical protein 0.0405 0.0544 0.0544
Brugia malayi ABC transporter transmembrane region family protein 0.0054 0.0001 0.0001
Giardia lamblia Multidrug resistance-associated protein 1 0.0054 0.0001 0.5
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0054 0.0001 0.0005
Echinococcus multilocularis carbonic anhydrase 0.0405 0.0544 0.0543
Mycobacterium ulcerans carbonic anhydrase 0.063 0.0894 0.4108
Trypanosoma cruzi multidrug resistance protein E, putative 0.0054 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.6506 1 1
Echinococcus multilocularis carbonic anhydrase 0.0405 0.0544 0.0543
Echinococcus multilocularis ATP binding cassette sub family B 0.0171 0.0183 0.0182
Leishmania major carbonic anhydrase family protein, putative 0.1458 0.2177 1
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0054 0.0001 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.0092 0.0092
Echinococcus granulosus multidrug resistance protein 1 0.0121 0.0104 0.0103
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0173 0.0186 0.2066
Brugia malayi Protein kinase domain containing protein 0.604 0.9278 0.9278
Echinococcus granulosus carbonic anhydrase 0.0405 0.0544 0.0543
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.6506 1 1
Schistosoma mansoni multidrug resistance protein 0.0173 0.0186 0.0184
Schistosoma mansoni carbonic anhydrase-related 0.0405 0.0544 0.0543
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0897 0.1308 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0054 0.0001 0.0005
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0173 0.0186 0.0184
Entamoeba histolytica P-glycoprotein-1 0.0173 0.0186 0.0848
Leishmania major ABC-thiol transporter 0.0054 0.0001 0.0005
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0173 0.0186 0.2066
Leishmania major pentamidine resistance protein 1 0.0054 0.0001 0.0005
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0054 0.0001 0.0001
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0054 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0447 0.061 0.061
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0405 0.0544 0.0544
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0054 0.0001 0.0005
Loa Loa (eye worm) multidrug resistance protein 3 0.0173 0.0186 0.0186
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1458 0.2177 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0897 0.1308 0.1307
Plasmodium falciparum multidrug resistance protein 1 0.0173 0.0186 0.3398
Trichomonas vaginalis abcb9, putative 0.0173 0.0186 0.2066
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0054 0.0001 0.0001
Trichomonas vaginalis abcb9, putative 0.0173 0.0186 0.2066
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0405 0.0544 0.0544
Schistosoma mansoni multidrug resistance protein 0.0173 0.0186 0.0184
Brugia malayi ABC transporter transmembrane region family protein 0.0054 0.0001 0.0001
Brugia malayi ABC transporter family protein 0.0173 0.0186 0.0186
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0173 0.0186 0.2066
Loa Loa (eye worm) hypothetical protein 0.0405 0.0544 0.0544
Trypanosoma brucei p-glycoprotein 0.0054 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0054 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0173 0.0186 0.0186
Brugia malayi hypothetical protein 0.0054 0.0001 0.0001
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0897 0.1308 0.1308
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0173 0.0186 0.3398
Echinococcus granulosus carbonic anhydrase 0.0405 0.0544 0.0543
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0054 0.0001 0.0008
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0054 0.0001 0.0008
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0054 0.0001 0.0005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0173 0.0186 0.0184
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0054 0.0001 0.0005
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0173 0.0186 0.0184
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0054 0.0001 0.5
Leishmania major carbonic anhydrase-like protein 0.0897 0.1308 0.6009
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0173 0.0186 0.2066
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0054 0.0001 0.0005
Echinococcus multilocularis carbonic anhydrase 0.0405 0.0544 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.063 0.0894 1
Trichomonas vaginalis ABC transporter, putative 0.0173 0.0186 0.2066
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0173 0.0186 0.2066
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.063 0.0894 0.7452
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0173 0.0186 0.5
Brugia malayi ABC transporter family protein 0.0054 0.0001 0.0001
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0173 0.0186 0.2066
Trypanosoma brucei carbonic anhydrase-like protein 0.0897 0.1308 1
Loa Loa (eye worm) ABC transporter 0.0054 0.0001 0.0001
Trichomonas vaginalis ABC transporter, putative 0.0173 0.0186 0.2066
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0054 0.0001 0.0005
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0054 0.0001 0.0008

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.