TDR Targets

Basic information

Technical information

TDR Targets ID: 175822
Name: 7-anilino-3-(2,6-dichlorophenyl)-1-methyl-1,6 -naphthyridin-2-one
MW: 396.269 | Formula: C21H15Cl2N3O
H donors: 1 H acceptors: 2 LogP: 5.21 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1c1cc2cnc(cc2n(c1=O)C)Nc1ccccc1)Cl
InChi: 1S/C21H15Cl2N3O/c1-26-18-11-19(25-14-6-3-2-4-7-14)24-12-13(18)10-15(21(26)27)20-16(22)8-5-9-17(20)23/h2-12H,1H3,(H,24,25)
InChiKey: GDAUEONAUDPBQF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(2,6-dichlorophenyl)-1-methyl-7-phenylazanyl-1,6-naphthyridin-2-one
3-(2,6-dichlorophenyl)-1-methyl-7-(phenylamino)-1,6-naphthyridin-2-one
1,6-naphthyridin-2(1H)-one deriv. 7n

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	fibroblast growth factor receptor 1	Starlite/ChEMBL	References
Mus musculus	platelet derived growth factor receptor, beta polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Fibroblast growth factor receptor precursor, putative	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0048	0.0724	0.0724
Brugia malayi	SRC-1	0.0048	0.0724	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0506	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0355	0.0355
Brugia malayi	hypothetical protein	0.0028	0.0355	0.0355
Echinococcus granulosus	roundabout 2	0.0036	0.0506	0.0506
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0123	0.2113	0.2113
Schistosoma mansoni	caspase-7 (C14 family)	0.0162	0.2832	0.2832
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0571	0.0571
Schistosoma mansoni	hypothetical protein	0.0162	0.2832	0.2832
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0126	0.218	0.218
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0028	0.0355	0.0355
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0724	0.0724
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0013	0.0071	0.0071
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0048	0.0724	0.0724
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0013	0.0071	0.0071
Echinococcus granulosus	inhibitor of apoptosis protein	0.0548	1	1
Schistosoma mansoni	hypothetical protein	0.0548	1	1
Echinococcus multilocularis	caspase 2	0.0162	0.2832	0.2832
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0044	0.0642	0.0642
Echinococcus granulosus	Immunoglobulin	0.0028	0.0355	0.0355
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0033	0.044	0.044
Schistosoma mansoni	tyrosine kinase	0.0012	0.0056	0.0056
Onchocerca volvulus	Deterin homolog	0.0548	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0355	0.0355
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0048	0.0724	0.0724
Echinococcus multilocularis	Immunoglobulin	0.0028	0.0355	0.0355
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0123	0.2113	0.2113
Onchocerca volvulus		0.0548	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0355	0.0355
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.0724	0.0724
Brugia malayi	protein-tyrosine kinase	0.0044	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0506	0.0506
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0548	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0048	0.0724	0.0724
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0724	0.0724
Loa Loa (eye worm)	SRC-1	0.0048	0.0724	0.0724
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0548	1	1
Schistosoma mansoni	tyrosine kinase	0.0013	0.0071	0.0071
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0162	0.2832	0.2832
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0548	1	1
Echinococcus granulosus	c src tyrosine kinase	0.0013	0.0071	0.0071
Echinococcus granulosus	tyrosine protein kinase HCK	0.0039	0.0558	0.0558
Brugia malayi	Tyrosine-protein kinase abl-1	0.0013	0.0071	0.0071
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0048	0.0724	0.0724
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0123	0.2113	0.2113
Echinococcus granulosus	twitchin	0.0032	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0355	0.0355
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0724	0.0724
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0028	0.0355	0.0355
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0048	0.0724	0.0724
Loa Loa (eye worm)	TK protein kinase	0.0039	0.0558	0.0558
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0044	0.0642	0.0642
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0039	0.0558	0.0558
Echinococcus multilocularis	neuroglian	0.0032	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0033	0.044	0.044
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0013	0.0071	0.0071
Echinococcus granulosus	apoptotic protease activating factor 1	0.0162	0.2832	0.2832
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0044	0.0642	0.0642
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.0724	0.0724
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0028	0.0355	0.0355
Schistosoma mansoni	nephrin	0.0032	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0162	0.2832	0.2832
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0548	1	1
Echinococcus multilocularis	roundabout 2	0.0036	0.0506	0.0506
Schistosoma mansoni	tyrosine kinase	0.0123	0.2113	0.2113
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0123	0.2113	0.2113
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0511	0.0511
Schistosoma mansoni	tyrosine kinase	0.0048	0.0724	0.0724
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.0724	0.0724
Echinococcus multilocularis	Immunoglobulin	0.0028	0.0355	0.0355
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0048	0.0724	0.0724
Echinococcus granulosus	tyrosine kinase	0.0044	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0162	0.2832	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0355	0.0355
Brugia malayi	Cell death protein 3 precursor	0.0162	0.2832	0.2832
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0048	0.0724	0.0724
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0048	0.0724	0.0724
Schistosoma mansoni	cell adhesion molecule	0.0033	0.044	0.044
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0548	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0048	0.0724	0.0724
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0013	0.0071	0.0071
Schistosoma mansoni	inhibitor of apoptosis protein	0.0548	1	1
Schistosoma mansoni	tyrosine kinase	0.0013	0.0071	0.0071
Schistosoma mansoni	vesicular amine transporter	0.0028	0.0355	0.0355
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0028	0.0355	0.0355
Brugia malayi	hypothetical protein	0.0162	0.2832	0.2832
Echinococcus multilocularis	c src tyrosine kinase	0.0013	0.0071	0.0071
Echinococcus granulosus	tyrosine protein kinase Blk	0.0044	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0548	1	1
Loa Loa (eye worm)	TK protein kinase	0.0044	0.0642	0.0642
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0048	0.0724	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0548	1	1
Echinococcus granulosus	defective proboscis extension response	0.0028	0.0355	0.0355
Loa Loa (eye worm)	TK protein kinase	0.0126	0.218	0.218
Brugia malayi	Fibronectin type III domain containing protein	0.0028	0.0355	0.0355
Echinococcus granulosus	neuroglian	0.0032	0.0421	0.0421
Entamoeba histolytica	protein kinase, putative	0.0039	0.0558	0.5
Schistosoma mansoni	tyrosine kinase	0.0048	0.0724	0.0724
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0044	0.0642	0.0642
Echinococcus granulosus	caspase 2	0.0162	0.2832	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0355	0.0355
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0571	0.0571
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0036	0.0511	0.0511

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.79 uM	Inhibitory activity against avian c-Src tyrosine kinase was determined.	ChEMBL.	10956222
IC50 (binding)	= 0.79 uM	Inhibitory activity against avian c-Src tyrosine kinase was determined.	ChEMBL.	10956222
IC50 (binding)	= 1.4 uM	Inhibitory activity against mouse PDGF beta receptor tyrosine kinase	ChEMBL.	10956222
IC50 (binding)	= 1.4 uM	Inhibitory activity against mouse PDGF beta receptor tyrosine kinase	ChEMBL.	10956222
IC50 (binding)	= 2.2 uM	Inhibitory activity against fibroblast growth factor receptor 1	ChEMBL.	10956222
IC50 (binding)	= 2.2 uM	Inhibitory activity against fibroblast growth factor receptor 1	ChEMBL.	10956222

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL323453
PubChem: 5328713

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 175822