Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0072 | 0.1195 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1195 | 0.1195 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0072 | 0.1195 | 0.1067 |
Onchocerca volvulus | 0.0072 | 0.1195 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1195 | 0.1195 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0072 | 0.1195 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.1195 | 0.1195 |
Schistosoma mansoni | gliotactin | 0.0072 | 0.1195 | 0.1195 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.1195 | 0.1067 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0072 | 0.1195 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1195 | 0.1195 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0.1195 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0072 | 0.1195 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0072 | 0.1195 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1195 | 0.1195 |
Echinococcus multilocularis | acetylcholinesterase | 0.0428 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0428 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1195 | 0.1195 |
Echinococcus multilocularis | acetylcholinesterase | 0.0428 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.1195 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0072 | 0.1195 | 0.1067 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0072 | 0.1195 | 0.1195 |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.1195 | 0.1195 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0072 | 0.1195 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0428 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.1195 | 0.1067 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0072 | 0.1195 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1195 | 0.1195 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.1195 | 0.1195 |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.1195 | 0.1195 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.436 | 0.436 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0072 | 0.1195 | 0.1067 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.1195 | 0.1195 |
Schistosoma mansoni | acetylcholinesterase | 0.0072 | 0.1195 | 0.1195 |
Echinococcus granulosus | carboxylesterase 5A | 0.0428 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0072 | 0.1195 | 0.1067 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0072 | 0.1195 | 0.1067 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0072 | 0.1195 | 0.1195 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.1195 | 0.1067 |
Brugia malayi | Carboxylesterase family protein | 0.0428 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0142 | 0.0142 |
Brugia malayi | hypothetical protein | 0.0072 | 0.1195 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1195 | 0.1195 |
Onchocerca volvulus | 0.0072 | 0.1195 | 0.5 | |
Echinococcus granulosus | neuroligin | 0.0072 | 0.1195 | 0.1067 |
Onchocerca volvulus | 0.0072 | 0.1195 | 0.5 | |
Onchocerca volvulus | 0.0072 | 0.1195 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0.1195 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0428 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1 uM | Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay | ChEMBL. | 23465611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.