Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.003 | 0.053 | 0.053 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0239 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0239 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0239 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0239 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0239 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.053 | 0.053 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.003 | 0.053 | 0.053 |
Echinococcus granulosus | proteasome prosome macropain | 0.0239 | 1 | 1 |
Onchocerca volvulus | Notchless protein homolog | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0239 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0239 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0239 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0239 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.003 | 0.053 | 0.053 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.8218 | 0.8218 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0239 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0024 | 0.0271 | 0.0271 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0239 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0018 | 0 | 0.5 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0239 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0024 | 0.0271 | 0.0271 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0239 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.06 uM | Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay | ChEMBL. | 23465611 |
Inhibition (binding) | = 73 % | Inhibition of human ERG at 1 uM by patch clamp assay relative to control | ChEMBL. | 23465611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.