Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0024 | 0.0271 | 0.0271 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0239 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.8218 | 0.8218 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0239 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0239 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0024 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0239 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0239 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0239 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0239 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0239 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.003 | 0.053 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.053 | 0.053 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0239 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0239 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.003 | 0.053 | 0.053 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0239 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0239 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0239 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.003 | 0.053 | 0.053 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0239 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0239 | 1 | 1 |
Onchocerca volvulus | Notchless protein homolog | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0239 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.06 uM | Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay | ChEMBL. | 23465611 |
Inhibition (binding) | = 73 % | Inhibition of human ERG at 1 uM by patch clamp assay relative to control | ChEMBL. | 23465611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.