TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.519 | Formula: C21H23N7OS
H donors: 1 H acceptors: 4 LogP: 2.07 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NCCn1ncc(c1)c1ccc2c(c1)OCCc1c2nc(s1)c1ncnn1C(C)C
InChi: 1S/C21H23N7OS/c1-13(2)28-20(23-12-25-28)21-26-19-16-4-3-14(15-10-24-27(11-15)7-6-22)9-17(16)29-8-5-18(19)30-21/h3-4,9-13H,5-8,22H2,1-2H3
InChiKey: SAQOOZKFNVGTOV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	582 aa	491 aa	25.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Brugia malayi	SRC-1	0.2317	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	activin receptor type	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0929	0.3823	0.3719
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TK/ALK protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0929	0.3823	0.3719
Brugia malayi	hypothetical protein	0.0929	0.3823	0.3823
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Entamoeba histolytica	serine/threonine kinase, putative	0.0929	0.3823	0.3823
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	ankyrin repeat protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2317	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	SH2 motif	0.1388	0.5864	0.5795
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.3823	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0929	0.3823	0.3719
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1388	0.5864	0.5795
Echinococcus granulosus	tyrosine protein kinase pr2	0.0929	0.3823	0.3719
Echinococcus multilocularis	SHC transforming protein 3	0.1388	0.5864	0.5795
Echinococcus multilocularis	SH2 motif	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus multilocularis	FL cytokine receptor	0.0929	0.3823	0.3719
Entamoeba histolytica	tyrosin kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	serine/threonine protein kinase	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein kinase csk	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0929	0.3823	0.3719
Entamoeba histolytica	receptor protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0929	0.3823	0.3719
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0929	0.3823	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1388	0.5864	0.5864
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus multilocularis	c src tyrosine kinase	0.2317	1	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2317	1	1
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein kinase csk	0.0929	0.3823	0.3719
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.2317	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1388	0.5864	0.5864
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Brugia malayi	Tensin	0.1388	0.5864	0.5864
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0222	0.0674	0.0674
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0232	0.0721	0.1887
Brugia malayi	hypothetical protein	0.2317	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0929	0.3823	0.3823
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Schistosoma mansoni	growth factor receptor-bound protein	0.1388	0.5864	0.5864
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1388	0.5864	0.5795
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Leishmania major	protein kinase, putative	0.0929	0.3823	0.5
Onchocerca volvulus		0.2317	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2317	1	1
Echinococcus granulosus	tensin	0.1388	0.5864	0.5795
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0929	0.3823	0.3823
Echinococcus granulosus	SH2 motif	0.1388	0.5864	0.5795
Brugia malayi	Protein kinase domain containing protein	0.2317	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	hypothetical protein	0.1388	0.5864	0.5864
Onchocerca volvulus		0.1388	0.5864	0.3305
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0929	0.3823	1
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0929	0.3823	0.3719
Trypanosoma cruzi	protein kinase, putative	0.0929	0.3823	1
Schistosoma mansoni	signal transduction protein lnk-related	0.1388	0.5864	0.5864
Loa Loa (eye worm)	TK/EPH protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Giardia lamblia	Kinase, NEK	0.0929	0.3823	1
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Brugia malayi	C-terminal src kinase protein 1	0.0929	0.3823	0.3823
Echinococcus multilocularis	heat shock protein 70	0.0929	0.3823	0.3719
Brugia malayi	protein-tyrosine kinase	0.2317	1	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TK/ACK protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	tyrosin kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0929	0.3823	0.3719
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Echinococcus granulosus	ephrin type A receptor 4 A	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TK/ROR protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus multilocularis	NCK adaptor protein	0.1388	0.5864	0.5795
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Onchocerca volvulus		0.1388	0.5864	0.3305
Brugia malayi	Raf kinase	0.0929	0.3823	0.3823
Giardia lamblia	Protein 21.1	0.0929	0.3823	1
Echinococcus multilocularis	tyrosine protein kinase	0.0929	0.3823	0.3719
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0929	0.3823	0.3719
Echinococcus granulosus	epidermal growth factor receptor	0.0929	0.3823	0.3719
Leishmania major	hypothetical protein, conserved	0.0929	0.3823	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TK/ABL protein kinase	0.2317	1	1
Echinococcus granulosus	protein tyrosine kinase	0.0929	0.3823	0.3719
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0929	0.3823	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1388	0.5864	0.5864
Brugia malayi	SH2 domain containing protein	0.1388	0.5864	0.5864
Echinococcus multilocularis		0.1388	0.5864	0.5795
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0929	0.3823	0.3719
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1388	0.5864	0.5795
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Schistosoma mansoni	suppressor of cytokine signaling	0.1388	0.5864	0.5864
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0929	0.3823	0.3719
Echinococcus granulosus	tyrosine protein kinase csk	0.0929	0.3823	0.3719
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0337	0.1185	0.1037
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Schistosoma mansoni	ephrin receptor	0.0929	0.3823	0.3823
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Echinococcus granulosus	kinase suppressor of Ras 1	0.0929	0.3823	0.3719
Entamoeba histolytica	serine/threonine kinase, putative	0.0929	0.3823	0.3823
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1388	0.5864	0.5795
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.3823	1
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Echinococcus granulosus	SHC transforming protein 3	0.1388	0.5864	0.5795
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0195	0.0556	0.1455
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TK/FAK protein kinase	0.0929	0.3823	0.3719
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0929	0.3823	0.3719
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0929	0.3823	0.3719
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0929	0.3823	0.3719
Echinococcus multilocularis	SH2 motif	0.1388	0.5864	0.5795
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Brugia malayi	SH2 domain containing protein	0.1388	0.5864	0.5864
Schistosoma mansoni	tyrosine kinase	0.2317	1	1
Onchocerca volvulus		0.2317	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1388	0.5864	0.5864
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0929	0.3823	0.3719
Schistosoma mansoni	shc transforming protein	0.1388	0.5864	0.5864
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1388	0.5864	0.5795
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1388	0.5864	0.5795
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	GTPase activating protein	0.1388	0.5864	0.5864
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	N chimaerin	0.1388	0.5864	0.5795
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0232	0.0721	0.1887
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0929	0.3823	0.3719
Brugia malayi	integrin-linked kinase	0.0929	0.3823	0.3823
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0929	0.3823	0.3719
Brugia malayi	Furin-like cysteine rich region family protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1388	0.5864	0.5795
Loa Loa (eye worm)	serine/threonine protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0929	0.3823	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0232	0.0721	0.0721
Loa Loa (eye worm)	SH2 domain-containing protein	0.1388	0.5864	0.5795
Schistosoma mansoni	ephrin receptor	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Echinococcus granulosus	SH2 motif	0.1388	0.5864	0.5795
Brugia malayi	Receptor family ligand binding region containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	tensin	0.1388	0.5864	0.5864
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0929	0.3823	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Plasmodium falciparum	protein kinase, putative	0.0929	0.3823	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1388	0.5864	0.3305
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0929	0.3823	1
Echinococcus granulosus	c src tyrosine kinase	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	epidermal growth factor receptor	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Giardia lamblia	Kinase, NEK	0.0929	0.3823	1
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	SH2 domain containing protein	0.1388	0.5864	0.5864
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2317	1	1
Trypanosoma brucei	protein kinase, putative	0.0929	0.3823	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0929	0.3823	0.3719
Brugia malayi	SH2 domain containing protein	0.1388	0.5864	0.5864
Onchocerca volvulus		0.1388	0.5864	0.3305
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Schistosoma mansoni	hypothetical protein	0.0929	0.3823	0.3823
Brugia malayi	Variant SH3 domain containing protein	0.1388	0.5864	0.5864
Schistosoma mansoni	hypothetical protein	0.1388	0.5864	0.5864
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0232	0.0721	0.0721
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0232	0.0721	0.1887
Schistosoma mansoni	growth factor receptor-bound protein	0.1388	0.5864	0.5864
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Echinococcus granulosus	tyrosine protein kinase csk	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0083	0.0057	0.0057
Echinococcus granulosus	tyrosine kinase	0.2317	1	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TK/INSR protein kinase	0.0929	0.3823	0.3719
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Brugia malayi	Protein kinase domain containing protein	0.2317	1	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0929	0.3823	0.3719
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Schistosoma mansoni	tensin	0.1388	0.5864	0.5864
Entamoeba histolytica	receptor protein kinase, putative	0.0929	0.3823	0.3823
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0929	0.3823	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.1388	0.5864	0.5795
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2317	1	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0929	0.3823	0.3719
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0929	0.3823	0.3719
Brugia malayi	Variant SH3 domain containing protein	0.1388	0.5864	0.5864
Echinococcus multilocularis	transfer RNA-Thr	0.0929	0.3823	0.3719
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0929	0.3823	0.3719
Echinococcus granulosus	integrin linked protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0929	0.3823	0.3719
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1388	0.5864	0.5795
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Brugia malayi	Protein kinase domain containing protein	0.2317	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1388	0.5864	0.5795
Echinococcus granulosus	receptor type guanylyl cyclase	0.0929	0.3823	0.3719
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1388	0.5864	0.5795
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus granulosus	SH2 domain containing protein 7	0.1388	0.5864	0.5795
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Toxoplasma gondii	STE kinase	0.0929	0.3823	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1388	0.5864	0.5795
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2317	1	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0929	0.3823	0.3823
Plasmodium falciparum	protein kinase, putative	0.0929	0.3823	0.5
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Leishmania major	protein kinase, putative	0.0929	0.3823	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	tensin-related	0.1388	0.5864	0.5864
Echinococcus granulosus	tyrosine protein kinase csk	0.0929	0.3823	0.3719
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Echinococcus granulosus	raf serine:threonine protein kinase	0.0929	0.3823	0.3719
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Onchocerca volvulus		0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Brugia malayi	Protein kinase domain containing protein	0.2317	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2317	1	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0929	0.3823	0.3719
Brugia malayi	RhoGAP domain containing protein	0.1388	0.5864	0.5864
Toxoplasma gondii	protein kinase	0.0929	0.3823	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2317	1	1
Echinococcus granulosus	protein kinase	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TK/FER protein kinase	0.0929	0.3823	0.3719
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Schistosoma mansoni	suppressor of cytokine signaling	0.1388	0.5864	0.5864
Plasmodium falciparum	tyrosine kinase-like protein	0.0929	0.3823	0.5
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0929	0.3823	0.3719
Schistosoma mansoni	serine/threonine protein kinase	0.0929	0.3823	0.3823
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Brugia malayi	hypothetical protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1388	0.5864	0.5795
Echinococcus multilocularis	tyrosine kinase	0.2317	1	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0929	0.3823	0.3823
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2317	1	1
Trichomonas vaginalis	STE family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0929	0.3823	0.3719
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0929	0.3823	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0208	0.0614	0.0614
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2317	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0929	0.3823	0.5
Echinococcus granulosus	insulin receptor	0.0929	0.3823	0.3719
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Loa Loa (eye worm)	SH2 domain-containing protein	0.1388	0.5864	0.5795
Loa Loa (eye worm)	TK/Met protein kinase	0.0929	0.3823	0.3719
Schistosoma mansoni	serine/threonine protein kinase	0.0929	0.3823	0.3823
Echinococcus granulosus	activated cdc42 kinase 1	0.0929	0.3823	0.3719
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0929	0.3823	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0929	0.3823	0.3719
Echinococcus multilocularis	tyrosine protein kinase shark	0.2317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1388	0.5864	0.5795
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2317	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2317	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	tensin	0.1388	0.5864	0.5795
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2317	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0929	0.3823	0.3719
Echinococcus granulosus	tyrosine protein kinase	0.0929	0.3823	0.3719
Echinococcus multilocularis	tyrosine kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	hypothetical protein, conserved	0.0929	0.3823	0.3823
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0232	0.0721	0.1887
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Brugia malayi	Guanylyl cyclase protein 23	0.0929	0.3823	0.3823
Trichomonas vaginalis	protein kinase atn1, putative	0.0929	0.3823	1
Entamoeba histolytica	tyrosin kinase, putative	0.0929	0.3823	0.3823
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2317	1	1
Loa Loa (eye worm)	TK protein kinase	0.2317	1	1
Schistosoma mansoni	tyrosine kinase	0.2317	1	1
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0929	0.3823	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0929	0.3823	0.3719
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1388	0.5864	0.5795
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.2317	1	1
Onchocerca volvulus		0.2317	1	1
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0929	0.3823	1
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	protein kinase	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0929	0.3823	0.3823
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1388	0.5864	0.5864
Trichomonas vaginalis	CAMK family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0929	0.3823	0.3719
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0929	0.3823	0.3719
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	nck2/grb4	0.1388	0.5864	0.5864
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus multilocularis	integrin linked protein kinase	0.0929	0.3823	0.3719
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1388	0.5864	0.5795
Echinococcus multilocularis	insulin receptor	0.0929	0.3823	0.3719
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2317	1	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1388	0.5864	0.5864
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2317	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0929	0.3823	0.3719
Echinococcus granulosus	NCK adaptor protein	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0929	0.3823	0.3719
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0929	0.3823	0.3719
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2317	1	1
Schistosoma mansoni	adapter molecule crk	0.1388	0.5864	0.5864
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1388	0.5864	0.5864
Echinococcus multilocularis	tensin	0.1388	0.5864	0.5795
Plasmodium falciparum	protein kinase, putative	0.0929	0.3823	0.5
Schistosoma mansoni	SH2A	0.1388	0.5864	0.5864
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1388	0.5864	0.5864
Brugia malayi	SH2 domain containing protein	0.1388	0.5864	0.5864
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0929	0.3823	0.3719
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1388	0.5864	0.5864
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	ankyrin repeat protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	hypothetical protein	0.1388	0.5864	0.5795
Echinococcus multilocularis	protein kinase	0.0929	0.3823	0.3719
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	protein tyrosine kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	cysteine surface protein, putative	0.0929	0.3823	0.3823
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0929	0.3823	0.3719
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1388	0.5864	0.5795
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TK family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Brugia malayi	hypothetical protein	0.1388	0.5864	0.5864
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0929	0.3823	0.3719
Echinococcus granulosus	tyrosine kinase	0.0929	0.3823	0.3719
Schistosoma mansoni	tyrosine protein kinase	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0232	0.0721	0.1887
Trypanosoma brucei	Pseudokinase, putative	0.0929	0.3823	1
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Schistosoma mansoni	tensin-related	0.1388	0.5864	0.5864
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Echinococcus granulosus	tyrosine protein kinase shark	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0337	0.1185	0.1037
Echinococcus multilocularis	signal transduction protein lnk realted	0.1388	0.5864	0.5795
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2317	1	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0929	0.3823	0.3823
Plasmodium falciparum	tyrosine kinase-like protein	0.0929	0.3823	0.5
Echinococcus multilocularis	N chimaerin	0.1388	0.5864	0.5795
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2317	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1388	0.5864	0.5864
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2317	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0929	0.3823	0.3719
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Brugia malayi	Sex muscle abnormal protein 5	0.1388	0.5864	0.5864
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0929	0.3823	0.3823
Brugia malayi	SH2 domain containing protein	0.1388	0.5864	0.5864
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Schistosoma mansoni	serine/threonine RGC	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Trypanosoma cruzi	protein kinase, putative	0.0929	0.3823	1
Schistosoma mansoni	tensin	0.1388	0.5864	0.5864
Onchocerca volvulus		0.1388	0.5864	0.3305
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0195	0.0556	0.1455
Schistosoma mansoni	serine/threonine protein kinase	0.0929	0.3823	0.3823
Echinococcus multilocularis	epidermal growth factor receptor	0.0929	0.3823	0.3719
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2317	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Brugia malayi	SH2 domain containing protein	0.2317	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0929	0.3823	0.5
Brugia malayi	SH2 domain containing protein	0.1388	0.5864	0.5864
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0929	0.3823	0.3719
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus granulosus	expressed conserved protein	0.1388	0.5864	0.5795
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0929	0.3823	0.5
Onchocerca volvulus		0.1388	0.5864	0.3305
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2317	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0929	0.3823	0.3823
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0929	0.3823	0.3719
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	SH2 domain containing protein 7	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus multilocularis	protein kinase	0.0929	0.3823	0.3719
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0929	0.3823	0.3823
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1388	0.5864	0.5795
Onchocerca volvulus		0.1388	0.5864	0.3305
Entamoeba histolytica	serine/threonine kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.2317	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2317	1	1
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Brugia malayi	SH2 domain containing protein	0.1388	0.5864	0.5864
Onchocerca volvulus		0.2317	1	1
Giardia lamblia	Kinase	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	phosphatidylinositol 3	0.0312	0.1077	0.0928
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Brugia malayi	SH2 domain containing protein	0.2317	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2317	1	1
Schistosoma mansoni	vav2	0.1388	0.5864	0.5864
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1388	0.5864	0.5795
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1388	0.5864	0.5795
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.3823	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0929	0.3823	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1388	0.5864	0.3305
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0929	0.3823	0.3719
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1388	0.5864	0.5795
Echinococcus granulosus	tyrosine protein kinase Srms	0.2317	1	1
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Onchocerca volvulus		0.2317	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0929	0.3823	0.3719
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0337	0.1185	0.1185
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2317	1	1
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0929	0.3823	0.3719
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Entamoeba histolytica	hypothetical protein	0.0208	0.0614	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0243	0.008
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1388	0.5864	0.5795
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Loa Loa (eye worm)	TK protein kinase	0.0929	0.3823	0.3719
Echinococcus granulosus	tyrosine protein kinase Blk	0.2317	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.3823	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0929	0.3823	0.3719
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0929	0.3823	0.3719
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0929	0.3823	0.3823
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1388	0.5864	0.5795
Brugia malayi	Tyrosine-protein kinase abl-1	0.2317	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Echinococcus granulosus	tyrosine kinase	0.2317	1	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	hypothetical protein	0.2317	1	1
Plasmodium vivax	protein kinase, putative	0.0929	0.3823	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0929	0.3823	0.3823
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1388	0.5864	0.5864
Loa Loa (eye worm)	hypothetical protein	0.1388	0.5864	0.5795
Echinococcus multilocularis	epidermal growth factor receptor	0.0929	0.3823	0.3719
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0929	0.3823	0.3719
Echinococcus multilocularis	tyrosine protein kinase csk	0.0929	0.3823	0.3719
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0929	0.3823	0.3719
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.015	0.015
Entamoeba histolytica	hypothetical protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0929	0.3823	0.3719
Entamoeba histolytica	tyrosin kinase, putative	0.0929	0.3823	0.3823
Trichomonas vaginalis	AGC family protein kinase	0.0929	0.3823	1
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase, putative	0.0929	0.3823	0.3823
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.3823	1
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0929	0.3823	0.3719
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.3823	1
Trichomonas vaginalis	TKL family protein kinase	0.0929	0.3823	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0929	0.3823	0.3823
Echinococcus multilocularis	tyrosine protein kinase csk	0.0929	0.3823	0.3719
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0107	0.0165	0.0165
Loa Loa (eye worm)	TK/FER protein kinase	0.0929	0.3823	0.3719
Loa Loa (eye worm)	STAT protein	0.1388	0.5864	0.5795
Entamoeba histolytica	protein kinase, putative	0.1388	0.5864	0.5864
Echinococcus granulosus	signal transduction protein lnk realted	0.1388	0.5864	0.5795
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1388	0.5864	0.5864
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Echinococcus granulosus	activin receptor type	0.0929	0.3823	0.3719
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0929	0.3823	0.3719
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0929	0.3823	0.3823
Loa Loa (eye worm)	SRC-1	0.2317	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.3823	1
Brugia malayi	Protein kinase domain containing protein	0.0929	0.3823	0.3823
Brugia malayi	ephrin receptor 1 precursor	0.0929	0.3823	0.3823
Loa Loa (eye worm)	hypothetical protein	0.0929	0.3823	0.3719
Schistosoma mansoni	tyrosine kinase	0.0929	0.3823	0.3823
Entamoeba histolytica	tyrosine kinase, putative	0.0929	0.3823	0.3823
Loa Loa (eye worm)	TK/FER protein kinase	0.2317	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823
Entamoeba histolytica	protein kinase domain containing protein	0.0929	0.3823	0.3823

Activities

Activity type	Activity value	Assay description	Source	Reference
CL (ADMET)		Plasma clearance in nude mouse at 1 mg/kg, iv	ChEMBL.	23540645
IC50 (binding)	= 2.4 nM	Inhibition of GST-fused human recombinant PI3Kbeta expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presence of [gamma-33P]-ATP	ChEMBL.	23540645
IC50 (binding)	= 22 nM	Inhibition of PI3Kalpha in human PC3 cells assessed as inhibition of AKT phosphorylation at Ser473 after 2 hrs by ELISA	ChEMBL.	23540645
IC50 (functional)	= 1.6 uM	Cytotoxicity against human PC3 cells assessed as growth inhibition after 4 days by Alamar blue assay	ChEMBL.	23540645
Ki (binding)	= 0.06 nM	Inhibition of GST-fused human recombinant PI3Kalpha expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presence of [gamma-33P]-ATP	ChEMBL.	23540645

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23540645

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2381376

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1760725