Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol 4-kinase, catalytic, beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0294 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0277 | 0.0277 |
Onchocerca volvulus | 0.0061 | 0.0277 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0061 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0358 | 0.424 | 0.424 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0061 | 0.0277 | 0.0277 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0791 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.424 | 0.424 |
Echinococcus granulosus | carbonic anhydrase | 0.0294 | 0.3381 | 0.3381 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0294 | 0.3381 | 0.3381 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0061 | 0.0277 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0358 | 0.424 | 0.424 |
Echinococcus granulosus | neuroligin | 0.0061 | 0.0277 | 0.0277 |
Schistosoma mansoni | hypothetical protein | 0.0294 | 0.3381 | 0.3381 |
Toxoplasma gondii | hypothetical protein | 0.0294 | 0.3381 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0791 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0.0277 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0294 | 0.3381 | 0.3381 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0061 | 0.0277 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0061 | 0.0277 | 0.0277 |
Echinococcus granulosus | acetylcholinesterase | 0.0358 | 0.424 | 0.424 |
Loa Loa (eye worm) | carboxylesterase | 0.0061 | 0.0277 | 0.0277 |
Echinococcus granulosus | carboxylesterase 5A | 0.0358 | 0.424 | 0.424 |
Echinococcus multilocularis | carbonic anhydrase | 0.0294 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0791 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0358 | 0.424 | 0.424 |
Schistosoma mansoni | carbonic anhydrase | 0.0294 | 0.3381 | 0.3381 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0791 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0294 | 0.3381 | 0.3381 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0791 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0791 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0358 | 0.424 | 0.424 |
Echinococcus granulosus | carbonic anhydrase | 0.0294 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0277 | 0.0277 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0791 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0.0277 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0061 | 0.0277 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0061 | 0.0277 | 0.0277 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0061 | 0.0277 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0294 | 0.3381 | 0.3381 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0294 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0277 | 0.0277 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0277 | 0.0277 |
Onchocerca volvulus | 0.0061 | 0.0277 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0358 | 0.424 | 0.424 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0061 | 0.0277 | 0.0277 |
Schistosoma mansoni | gliotactin | 0.0061 | 0.0277 | 0.0277 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0061 | 0.0277 | 0.0277 |
Giardia lamblia | Phosphatidylinositol 4-kinase | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0277 | 0.0277 |
Plasmodium vivax | phosphatidylinositol 4-kinase, putative | 0.004 | 0 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0294 | 0.3381 | 0.3381 |
Brugia malayi | Carboxylesterase family protein | 0.0061 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | carboxylesterase | 0.0061 | 0.0277 | 0.0277 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0061 | 0.0277 | 0.0277 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0061 | 0.0277 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0061 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0277 | 0.0277 |
Plasmodium falciparum | carbonic anhydrase | 0.0294 | 0.3381 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0061 | 0.0277 | 0.0277 |
Brugia malayi | Carboxylesterase family protein | 0.0061 | 0.0277 | 0.0277 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0294 | 0.3381 | 0.3381 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0061 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0791 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0791 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0061 | 0.0277 | 0.0277 |
Echinococcus multilocularis | acetylcholinesterase | 0.0358 | 0.424 | 0.424 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0791 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.3381 | 0.3381 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.424 | 0.424 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.3381 | 0.3381 |
Schistosoma mansoni | acetylcholinesterase | 0.0061 | 0.0277 | 0.0277 |
Brugia malayi | Carboxylesterase family protein | 0.0358 | 0.424 | 0.424 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0358 | 0.424 | 0.424 |
Echinococcus granulosus | carbonic anhydrase II | 0.0791 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0294 | 0.3381 | 0.3381 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0358 | 0.424 | 0.424 |
Echinococcus granulosus | carbonic anhydrase | 0.0294 | 0.3381 | 0.3381 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0615 | 0.7662 | 0.7662 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0294 | 0.3381 | 0.3381 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0061 | 0.0277 | 0.0277 |
Onchocerca volvulus | 0.0061 | 0.0277 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0061 | 0.0277 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0615 | 0.7662 | 0.7662 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0061 | 0.0277 | 0.0277 |
Echinococcus multilocularis | carbonic anhydrase | 0.0294 | 0.3381 | 0.3381 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0061 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0277 | 0.0277 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22 nM | Inhibition of PI4K3beta (unknown origin) | ChEMBL. | 23726345 |
IC50 (ADMET) | > 30 uM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 23726345 |
permeability (ADMET) | = 18 ucm/s | Permeability across apical to basolateral side in human Caco2 cells | ChEMBL. | 23726345 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.