Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0.0089 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0638 | 0.0638 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0089 | 0.0089 |
Schistosoma mansoni | ferritin | 0.001 | 0.0089 | 0.0089 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0089 | 0.0089 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0006 | 0.0002 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0638 | 0.0638 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0638 | 0.0638 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0224 | 0.0224 |
Entamoeba histolytica | protein kinase, putative | 0.0006 | 0.0002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0623 | 0.0623 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0224 | 0.0224 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0.0089 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.0638 | 1 | |
Echinococcus multilocularis | musashi | 0.0031 | 0.0638 | 0.0638 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0.0089 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0.0089 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0.0089 | 0.5 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0398 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0.0089 | 0.5 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0.0089 | 0.5 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0398 | 1 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0266 | 0.0266 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0.0089 | 0.5 |
Echinococcus granulosus | ferritin | 0.001 | 0.0089 | 0.0089 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0089 | 0.0089 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0638 | 0.0638 |
Schistosoma mansoni | lamin | 0.0031 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0209 | 0.0209 |
Echinococcus granulosus | expressed protein | 0.001 | 0.0089 | 0.0089 |
Schistosoma mansoni | ferritin | 0.001 | 0.0089 | 0.0089 |
Schistosoma mansoni | protein kinase | 0.0398 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0638 | 0.0638 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0266 | 0.0266 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0089 | 0.0089 |
Schistosoma mansoni | ferritin | 0.001 | 0.0089 | 0.0089 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0638 | 0.0638 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0008 | 0.0038 | 0.0038 |
Schistosoma mansoni | lamin | 0.0031 | 0.0638 | 0.0638 |
Echinococcus granulosus | lamin | 0.0031 | 0.0638 | 0.0638 |
Onchocerca volvulus | 0.0031 | 0.0638 | 1 | |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0224 | 0.0224 |
Schistosoma mansoni | ferritin | 0.001 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0398 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0638 | 0.0638 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0398 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.