Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0062 | 0 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0301 | 0.3192 | 1 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0456 | 0.0456 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0301 | 0.3192 | 0.3192 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0811 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0367 | 0.4075 | 0.4075 |
Brugia malayi | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Leishmania major | carbonic anhydrase-like protein | 0.0811 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0367 | 0.4075 | 0.4075 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0811 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.4075 | 0.4075 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.3192 | 0.3192 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0367 | 0.4075 | 0.4075 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0047 | 0.0047 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0811 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0301 | 0.3192 | 0.3192 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0301 | 0.3192 | 0.3192 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0367 | 0.4075 | 0.4075 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0367 | 0.4075 | 0.4075 |
Brugia malayi | Carboxylesterase family protein | 0.0367 | 0.4075 | 0.4075 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.0456 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0456 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0367 | 0.4075 | 0.4075 |
Onchocerca volvulus | 0.0096 | 0.0456 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0367 | 0.4075 | 0.4075 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0301 | 0.3192 | 0.3192 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0456 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0811 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 0.0456 | 0.0456 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0811 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0301 | 0.3192 | 0.3192 |
Schistosoma mansoni | carbonic anhydrase | 0.0301 | 0.3192 | 0.3192 |
Onchocerca volvulus | 0.0096 | 0.0456 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0301 | 0.3192 | 0.3192 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0301 | 0.3192 | 0.3192 |
Echinococcus granulosus | acetylcholinesterase | 0.0367 | 0.4075 | 0.4075 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0301 | 0.3192 | 0.3192 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0301 | 0.3192 | 0.3192 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.3192 | 0.3192 |
Echinococcus granulosus | carbonic anhydrase II | 0.0811 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0456 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0301 | 0.3192 | 0.3192 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0811 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.4075 | 0.4075 |
Echinococcus granulosus | carbonic anhydrase | 0.0301 | 0.3192 | 0.3192 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0811 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 0.3192 | 0.3192 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0301 | 0.3192 | 0.3192 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Onchocerca volvulus | 0.0096 | 0.0456 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0367 | 0.4075 | 0.4075 |
Echinococcus granulosus | carbonic anhydrase | 0.0301 | 0.3192 | 0.3192 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0811 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0301 | 0.3192 | 0.3192 |
Echinococcus granulosus | carboxylesterase 5A | 0.0367 | 0.4075 | 0.4075 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.3192 | 0.3192 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.0456 | 0.0456 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0456 | 0.0456 |
Echinococcus granulosus | carbonic anhydrase | 0.0301 | 0.3192 | 0.3192 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0811 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0301 | 0.3192 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 0.0456 | 0.0456 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.23 uM | Activation of human recombinant glucokinase by matrix assay in presence of glucose | ChEMBL. | 23831135 |
Ratio (binding) | = 0.13 | Activation of human recombinant glucokinase assessed as ratio of the glucokinase Km at maximum compound concentration to the enzyme Km in the absence of compound | ChEMBL. | 23831135 |
Ratio (binding) | = 0.84 | Activation of human recombinant glucokinase assessed as ratio of the enzyme velocity at maximum compound concentration to the enzyme Km in the absence of compound | ChEMBL. | 23831135 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.