Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0193 | 0.0056 | 0.5 |
Loa Loa (eye worm) | TRE-1 protein | 0.0286 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0631 | 0.4098 | 0.4098 |
Onchocerca volvulus | Trehalase homolog | 0.0286 | 0.0913 | 0.5088 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0288 | 0.0929 | 1 |
Loa Loa (eye worm) | trehalase | 0.0286 | 0.0913 | 0.0913 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0286 | 0.0913 | 0.9825 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0913 | 0.0913 |
Echinococcus granulosus | beta galactosidase | 0.0631 | 0.4098 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0111 | 0.1027 |
Echinococcus multilocularis | beta galactosidase | 0.0631 | 0.4098 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0288 | 0.0929 | 1 |
Schistosoma mansoni | beta-galactosidase | 0.0631 | 0.4098 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0565 | 0.3485 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0288 | 0.0929 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0193 | 0.0056 | 0.5 |
Onchocerca volvulus | 0.0286 | 0.0913 | 0.5088 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0288 | 0.0929 | 1 |
Onchocerca volvulus | 0.0286 | 0.0913 | 0.5088 | |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0913 | 0.0913 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0288 | 0.0929 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0288 | 0.0929 | 1 |
Onchocerca volvulus | 0.0286 | 0.0913 | 0.5088 | |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | TRE-2 protein | 0.0286 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | trehalase | 0.0286 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0565 | 0.3485 | 0.3485 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0111 | 0.1027 |
Onchocerca volvulus | 0.0286 | 0.0913 | 0.5088 | |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | trehalase | 0.0286 | 0.0913 | 0.0913 |
Trichomonas vaginalis | trehalase, putative | 0.0286 | 0.0913 | 0.9825 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0288 | 0.0929 | 0.0062 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0288 | 0.0929 | 0.0929 |
Onchocerca volvulus | 0.038 | 0.1777 | 1 | |
Onchocerca volvulus | 0.0286 | 0.0913 | 0.5088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 91 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition at 6.25 ug/ml after 5 to 8 days by microplate alamar blue assay relative to control | ChEMBL. | 23876988 |
MIC (functional) | < 6.25 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 to 8 days by microplate alamar blue assay | ChEMBL. | 23876988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.