Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Cavia porcellus | Sigma-1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neuroglian | 0.0044 | 0.02 | 0.0354 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.3592 | 0.3592 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.5654 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0148 | 0.2751 | 0.0952 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.3592 | 0.3592 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.5654 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0036 | 0.0006 | 0.0011 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0198 | 0.3975 | 0.7031 |
Schistosoma mansoni | nephrin | 0.0044 | 0.02 | 0.0354 |
Schistosoma mansoni | tyrosine kinase | 0.0198 | 0.3975 | 0.7031 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0198 | 0.3975 | 0.7031 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.5654 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0043 | 0.0164 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0164 | 0.0164 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0043 | 0.0164 | 0.0291 |
Echinococcus granulosus | twitchin | 0.0044 | 0.02 | 0.0354 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.5654 | 0.5654 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0207 | 0.4175 | 0.4175 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0198 | 0.3975 | 0.7031 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.5654 | 1 |
Echinococcus granulosus | neuroglian | 0.0044 | 0.02 | 0.0354 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.5654 | 0.5654 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0051 | 0.0365 | 0.0645 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4682 | 0.4682 |
Echinococcus multilocularis | roundabout 2 | 0.0051 | 0.0365 | 0.0645 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0365 | 0.0365 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0198 | 0.3975 | 0.7031 |
Loa Loa (eye worm) | TK protein kinase | 0.0207 | 0.4175 | 0.4175 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 27.9 nM | Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrs | ChEMBL. | 23802889 |
Ki (binding) | = 2120 nM | Displacement of (+)- [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membrane homogenates by scintillation counting analysis | ChEMBL. | 23802889 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.