Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0233 | 0.0378 | 0.0378 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0241 | 0.0397 | 0.0892 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Echinococcus multilocularis | roundabout 2 | 0.014 | 0.0132 | 0.0248 |
Echinococcus granulosus | peroxidasin | 0.014 | 0.0132 | 0.0248 |
Loa Loa (eye worm) | casein kinase II | 0.0293 | 0.0533 | 0.0533 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.1785 | 0.4451 | 0.8344 |
Brugia malayi | Prion-like- | 0.014 | 0.0132 | 0.0132 |
Schistosoma mansoni | roundabout | 0.014 | 0.0132 | 0.0298 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Mycobacterium leprae | Possible transporter protein | 0.0233 | 0.0378 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0233 | 0.0378 | 0.0378 |
Echinococcus multilocularis | lachesin | 0.014 | 0.0132 | 0.0248 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0165 | 0.02 | 0.0448 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.1785 | 0.4451 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0241 | 0.0397 | 0.0397 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0165 | 0.02 | 0.0374 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1785 | 0.4451 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0132 | 0.0132 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Schistosoma mansoni | vesicular amine transporter | 0.0241 | 0.0397 | 0.0892 |
Schistosoma mansoni | neuroglian | 0.014 | 0.0132 | 0.0298 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.0378 | 0.0848 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Brugia malayi | casein kinase II, putaitve | 0.0293 | 0.0533 | 0.0533 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.1785 | 0.4451 | 0.4451 |
Schistosoma mansoni | cell adhesion molecule | 0.014 | 0.0132 | 0.0298 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0648 | 0.1465 | 0.2747 |
Trypanosoma brucei | Casein kinase II | 0.1785 | 0.4451 | 1 |
Echinococcus granulosus | single minded 2 | 0.0233 | 0.0378 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0397 | 0.0397 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0233 | 0.0378 | 0.0848 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1785 | 0.4451 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0241 | 0.0397 | 0.0892 |
Plasmodium vivax | unspecified product | 0.1785 | 0.4451 | 1 |
Schistosoma mansoni | nephrin | 0.0302 | 0.0558 | 0.1254 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0132 | 0.0132 |
Echinococcus multilocularis | hemicentin 1 | 0.014 | 0.0132 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0132 | 0.0132 |
Brugia malayi | hypothetical protein | 0.0241 | 0.0397 | 0.0397 |
Echinococcus multilocularis | roundabout 2 | 0.014 | 0.0132 | 0.0248 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0147 | 0.015 | 0.0281 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0165 | 0.02 | 0.0374 |
Echinococcus granulosus | twitchin | 0.033 | 0.0632 | 0.1184 |
Echinococcus multilocularis | neuroglian | 0.0302 | 0.0558 | 0.1046 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.014 | 0.0132 | 0.0132 |
Echinococcus granulosus | defective proboscis extension response | 0.0241 | 0.0397 | 0.0744 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0147 | 0.015 | 0.0337 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.1002 | 0.2395 | 0.449 |
Echinococcus granulosus | roundabout 2 | 0.014 | 0.0132 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0132 | 0.0132 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0233 | 0.0378 | 0.0848 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.1002 | 0.2395 | 0.2569 |
Giardia lamblia | Kinase, CMGC CK2 | 0.1785 | 0.4451 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0147 | 0.015 | 0.0281 |
Brugia malayi | Casein kinase II, alpha chain | 0.1785 | 0.4451 | 0.4451 |
Echinococcus granulosus | contactin | 0.014 | 0.0132 | 0.0248 |
Echinococcus granulosus | Immunoglobulin | 0.0241 | 0.0397 | 0.0744 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1002 | 0.2395 | 0.3792 |
Echinococcus multilocularis | hemicentin 1 | 0.014 | 0.0132 | 0.0248 |
Schistosoma mansoni | cell adhesion molecule | 0.0319 | 0.0603 | 0.1354 |
Echinococcus granulosus | roundabout 2 | 0.014 | 0.0132 | 0.0248 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0147 | 0.015 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0397 | 0.0397 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.014 | 0.0132 | 0.0142 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.1002 | 0.2395 | 0.449 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.0603 | 0.0603 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0397 | 0.0397 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2162 | 0.5443 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.1785 | 0.4451 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0241 | 0.0397 | 0.0744 |
Trypanosoma brucei | Casein kinase II subunit beta, putative | 0.1002 | 0.2395 | 0.486 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Schistosoma mansoni | cell adhesion molecule | 0.014 | 0.0132 | 0.0298 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Echinococcus multilocularis | peroxidasin | 0.014 | 0.0132 | 0.0248 |
Trichomonas vaginalis | protein kinase ck2-beta, putative | 0.0293 | 0.0533 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0397 | 0.0397 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0319 | 0.0603 | 0.113 |
Echinococcus granulosus | neuroglian | 0.014 | 0.0132 | 0.0248 |
Brugia malayi | Peroxidasin | 0.014 | 0.0132 | 0.0132 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.014 | 0.0132 | 0.0248 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.3898 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1785 | 0.4451 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1785 | 0.4451 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Echinococcus granulosus | roundabout 2 | 0.0381 | 0.0764 | 0.1433 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0394 | 0.0799 | 0.1796 |
Giardia lamblia | Casein kinase II beta chain | 0.1002 | 0.2395 | 0.4752 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.014 | 0.0132 | 0.0248 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1785 | 0.4451 | 0.798 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.0764 | 0.0764 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.1785 | 0.4451 | 0.8344 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1002 | 0.2395 | 0.3792 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.0764 | 0.0764 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0233 | 0.0378 | 0.0848 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0394 | 0.0799 | 0.1498 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0394 | 0.0799 | 0.1498 |
Entamoeba histolytica | hypothetical protein | 0.2162 | 0.5443 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0147 | 0.015 | 0.015 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0168 | 0.0206 | 0.0206 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0147 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0132 | 0.0132 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.014 | 0.0132 | 0.0248 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0233 | 0.0378 | 0.0708 |
Echinococcus multilocularis | Immunoglobulin | 0.0241 | 0.0397 | 0.0744 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0233 | 0.0378 | 0.0848 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Echinococcus multilocularis | roundabout 2 | 0.0381 | 0.0764 | 0.1433 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0165 | 0.02 | 0.0374 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Echinococcus granulosus | neuroglian | 0.0302 | 0.0558 | 0.1046 |
Schistosoma mansoni | neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule | 0.014 | 0.0132 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0397 | 0.0397 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0233 | 0.0378 | 0.0708 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.014 | 0.0132 | 0.0132 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0233 | 0.0378 | 0.0848 |
Trypanosoma cruzi | casein kinase II, putative | 0.1785 | 0.4451 | 0.6746 |
Echinococcus granulosus | lachesin | 0.014 | 0.0132 | 0.0248 |
Leishmania major | casein kinase II, putative | 0.1785 | 0.4451 | 1 |
Trichomonas vaginalis | protein kinase ck2-beta, putative | 0.0293 | 0.0533 | 0.0383 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1002 | 0.2395 | 0.3792 |
Brugia malayi | Csnk2b protein | 0.1002 | 0.2395 | 0.2395 |
Onchocerca volvulus | 0.3569 | 0.9137 | 0.98 | |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1785 | 0.4451 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.1002 | 0.2395 | 0.2569 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1002 | 0.2395 | 0.4953 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.2344 | 0.5921 | 0.5921 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0241 | 0.0397 | 0.0397 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0394 | 0.0799 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0132 | 0.0132 |
Echinococcus multilocularis | Immunoglobulin | 0.0241 | 0.0397 | 0.0744 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.2121 | 0.5335 | 1 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0233 | 0.0378 | 0.0848 |
Schistosoma mansoni | tyrosine kinase | 0.015 | 0.0158 | 0.0355 |
Schistosoma mansoni | septate junction protein | 0.014 | 0.0132 | 0.0298 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1785 | 0.4451 | 1 |
Schistosoma mansoni | nephrin | 0.014 | 0.0132 | 0.0298 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0394 | 0.0799 | 0.0799 |
Onchocerca volvulus | 0.2344 | 0.5921 | 0.635 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2162 | 0.5443 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.364 | 0.9324 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0233 | 0.0378 | 0.0708 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.014 | 0.0132 | 0.0248 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.014 | 0.0132 | 0.0132 |
Echinococcus granulosus | hemicentin 1 | 0.014 | 0.0132 | 0.0248 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0233 | 0.0378 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0378 | 0.0378 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.014 | 0.0132 | 0.0132 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1785 | 0.4451 | 1 |
Schistosoma mansoni | casein kinase II beta subunit | 0.1002 | 0.2395 | 0.5381 |
Schistosoma mansoni | cell adhesion molecule | 0.014 | 0.0132 | 0.0298 |
Schistosoma mansoni | titin | 0.014 | 0.0132 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0397 | 0.0397 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.1785 | 0.4451 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.2121 | 0.5335 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0147 | 0.015 | 0.0281 |
Schistosoma mansoni | protein kinase | 0.1785 | 0.4451 | 1 |
Schistosoma mansoni | septate junction protein | 0.014 | 0.0132 | 0.0298 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Echinococcus multilocularis | neuroglian | 0.014 | 0.0132 | 0.0248 |
Entamoeba histolytica | casein kinase, putative | 0.1785 | 0.4451 | 0.798 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0293 | 0.0533 | 0.0383 |
Loa Loa (eye worm) | Csnk2b protein | 0.1002 | 0.2395 | 0.2395 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0165 | 0.02 | 0.0374 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 1.2 % | Antiproliferative activity against human DU145 cells assessed as growth inhibition at 10'-9 M after 48 hrs by BrdU-incorporation assay relative to untreated cells | ChEMBL. | 23816043 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.