Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0904 | 0.5787 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1531 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1506 | 0.9826 | 0.9706 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0904 | 0.5787 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0904 | 0.5787 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1506 | 0.9826 | 0.9826 |
Echinococcus multilocularis | sodium channel protein | 0.0048 | 0.0045 | 0.0005 |
Giardia lamblia | Hypothetical protein | 0.0904 | 0.5787 | 0.5 |
Echinococcus granulosus | sodium channel protein | 0.0048 | 0.0045 | 0.0005 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1531 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1531 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1506 | 0.9826 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1506 | 0.9826 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0878 | 0.5614 | 0.5614 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0048 | 0.0045 | 0.0005 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0653 | 0.4107 | 0.4081 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0047 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.1531 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1531 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0904 | 0.5787 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1531 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1506 | 0.9826 | 0.9826 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1531 | 1 | 1 |
Onchocerca volvulus | 0.1531 | 1 | 0.5 | |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0047 | 0.0039 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.014 uM | Antiproliferative activity against CSF-1-stimulated mouse 3T3 cells expressing CSF1R | ChEMBL. | 23842474 |
IC50 (binding) | = 7 uM | Inhibition of human Nav1.5 | ChEMBL. | 23842474 |
IC50 (binding) | = 11 uM | Inhibition of human ERG | ChEMBL. | 23842474 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 23842474 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.