Detailed information for compound 1769664

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 451.536 | Formula: C25H30FN5O2
  • H donors: 2 H acceptors: 3 LogP: 4.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2nnc(c(c2cc1C1CCN(CC1)C(C)C)Nc1ccc(cc1F)C)C(=O)N
  • InChi: 1S/C25H30FN5O2/c1-14(2)31-9-7-16(8-10-31)17-12-18-21(13-22(17)33-4)29-30-24(25(27)32)23(18)28-20-6-5-15(3)11-19(20)26/h5-6,11-14,16H,7-10H2,1-4H3,(H2,27,32)(H,28,29)
  • InChiKey: GUYOKNBONQDXMG-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens sodium channel, voltage-gated, type V, alpha subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0904 0.5787 0.5
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1531 1 1
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1506 0.9826 0.9706
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0 0.5
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0904 0.5787 0.5
Mycobacterium ulcerans hypothetical protein 0.0904 0.5787 0.5
Loa Loa (eye worm) hypothetical protein 0.1506 0.9826 0.9826
Echinococcus multilocularis sodium channel protein 0.0048 0.0045 0.0005
Giardia lamblia Hypothetical protein 0.0904 0.5787 0.5
Echinococcus granulosus sodium channel protein 0.0048 0.0045 0.0005
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1531 1 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1531 1 1
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1506 0.9826 0.9706
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1506 0.9826 0.9706
Loa Loa (eye worm) hypothetical protein 0.0878 0.5614 0.5614
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0048 0.0045 0.0005
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0653 0.4107 0.4081
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0047 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.1531 1 1
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1531 1 1
Giardia lamblia Hypothetical protein 0.0904 0.5787 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1531 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0 0.5
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1506 0.9826 0.9826
Schistosoma mansoni 6-phosphofructokinase 0.1531 1 1
Onchocerca volvulus 0.1531 1 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0047 0.0039 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.014 uM Antiproliferative activity against CSF-1-stimulated mouse 3T3 cells expressing CSF1R ChEMBL. 23842474
IC50 (binding) = 7 uM Inhibition of human Nav1.5 ChEMBL. 23842474
IC50 (binding) = 11 uM Inhibition of human ERG ChEMBL. 23842474

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 23842474

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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