Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1531 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0048 | 0.0045 | 0.0005 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0047 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.1506 | 0.9826 | 0.9826 |
Echinococcus granulosus | sodium channel protein | 0.0048 | 0.0045 | 0.0005 |
Onchocerca volvulus | 0.1531 | 1 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1506 | 0.9826 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0653 | 0.4107 | 0.4081 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1531 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0904 | 0.5787 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0904 | 0.5787 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1531 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1506 | 0.9826 | 0.9706 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0904 | 0.5787 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1531 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0904 | 0.5787 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0904 | 0.5787 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0047 | 0.0039 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1531 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0878 | 0.5614 | 0.5614 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1506 | 0.9826 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1531 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1506 | 0.9826 | 0.9826 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0048 | 0.0045 | 0.0005 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1531 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.014 uM | Antiproliferative activity against CSF-1-stimulated mouse 3T3 cells expressing CSF1R | ChEMBL. | 23842474 |
IC50 (binding) | = 7 uM | Inhibition of human Nav1.5 | ChEMBL. | 23842474 |
IC50 (binding) | = 11 uM | Inhibition of human ERG | ChEMBL. | 23842474 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 23842474 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.