Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0345 | 0.0666 | 0.5 |
Brugia malayi | hypothetical protein | 0.0781 | 0.2241 | 0.4998 |
Loa Loa (eye worm) | haspin protein kinase | 0.0784 | 0.2254 | 0.2254 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.035 | 0.0682 | 0.0017 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.035 | 0.0682 | 0.0017 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0781 | 0.2241 | 0.1687 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0211 | 0.018 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0781 | 0.2241 | 0.1687 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0083 | 0.0083 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 0.1067 | 0.043 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0345 | 0.0666 | 0.1486 |
Loa Loa (eye worm) | haspin protein kinase | 0.0781 | 0.2241 | 0.2241 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0345 | 0.0666 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 0.1067 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.1401 | 0.4483 | 0.4483 |
Brugia malayi | prolyl oligopeptidase family protein | 0.035 | 0.0682 | 0.1522 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0781 | 0.2241 | 0.1687 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0456 | 0.1067 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.2926 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0345 | 0.0666 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.035 | 0.0682 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.2926 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.035 | 0.0682 | 0.0017 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0345 | 0.0666 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.035 | 0.0682 | 0.0682 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.2926 | 1 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0781 | 0.2241 | 0.2241 |
Brugia malayi | hypothetical protein | 0.1401 | 0.4483 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1401 | 0.4483 | 0.4483 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0781 | 0.2241 | 0.1687 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0781 | 0.2241 | 0.1687 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0781 | 0.2241 | 0.1687 |
Brugia malayi | GSG2 | 0.0781 | 0.2241 | 0.4998 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0345 | 0.0666 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.39 nM | Inhibition of human purified His-tagged DPP-4 assessed as cleavage of substrate using Gly-Pro-AMC chromogenic substrate after 60 mins by fluorescence spectrophotometry | ChEMBL. | 23938053 |
IC50 (binding) | = 630 nM | Inhibition of human purified His-tagged DPP-9 assessed as cleavage of substrate using Gly-Pro-AMC chromogenic substrate after 60 mins by fluorescence spectrophotometry | ChEMBL. | 23938053 |
IC50 (binding) | = 640 nM | Inhibition of human purified His-tagged DPP-7 assessed as cleavage of substrate using Gly-Pro-AMC chromogenic substrate after 60 mins by fluorescence spectrophotometry | ChEMBL. | 23938053 |
IC50 (binding) | = 680 nM | Inhibition of human purified His-tagged DPP-8 assessed as cleavage of substrate using Gly-Pro-AMC chromogenic substrate after 60 mins by fluorescence spectrophotometry | ChEMBL. | 23938053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.