Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 5 | Starlite/ChEMBL | References |
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 3 | Starlite/ChEMBL | References |
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 6 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.019 | 0.5909 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0306 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0271 | 0.8768 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0073 | 0.1815 | 0.3071 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0073 | 0.1815 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.019 | 0.5909 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.1647 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.0947 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0947 | 0.0947 |
Schistosoma mansoni | hypothetical protein | 0.0292 | 0.9518 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.205 | 0.2154 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.1181 | 0.6505 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0947 | 0.0995 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.1181 | 0.1241 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0947 | 0.1603 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0306 | 1 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0947 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 1 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0947 | 0.5 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0947 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1181 | 0.1181 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0947 | 0.5219 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.1181 | 0.1181 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.1181 | 0.1998 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.1181 | 0.1998 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0947 | 0.1603 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0947 | 0.5219 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.205 | 0.2154 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1477 | 0.1477 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.1647 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0947 | 0.0995 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.1181 | 0.1998 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0271 | 0.8768 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0073 | 0.1815 | 0.3071 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.1181 | 0.1998 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0947 | 0.1603 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0073 | 0.1815 | 0.1815 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0947 | 0.0995 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2.7 uM | Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay | ChEMBL. | 23916258 |
EC50 (binding) | = 6.8 uM | Activation of GIRK1/4 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay | ChEMBL. | 23916258 |
Efficacy (binding) | = 94 % | Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells at 20 uM after 4 mins by thallium flux-based fluorescence assay relative to ML297 | ChEMBL. | 23916258 |
Efficacy (binding) | = 106 % | Activation of GIRK1/4 (unknown origin) transfected in HEK293 cells at 20 uM after 4 mins by thallium flux-based fluorescence assay relative to ML297 | ChEMBL. | 23916258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.