Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0029 | 0.0033 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.2676 | 0.2652 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0279 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0033 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0279 | 1 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0279 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0279 | 1 | 1 |
Echinococcus multilocularis | microtubule associated serine:threonine protein | 0.0125 | 0.3882 | 0.3862 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0029 | 0.0033 | 1 |
Brugia malayi | microtubule-associated serine/threonine protein kinase 2 (MAST2) | 0.0097 | 0.274 | 0.2716 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.9 uM | Inhibition of human recombinant histidine-tagged full-length JNK1 expressed in insect cells using GST-tagged MAP2K7 as substrate after 1 hr by luminescence plate reader analysis | ChEMBL. | 23916259 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.