Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.0045 | 0.0013 | 0.0051 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0176 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0085 | 0.012 | 0.0474 |
Schistosoma mansoni | nuclear hormone receptor | 0.0085 | 0.012 | 0.0139 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0085 | 0.012 | 0.012 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0085 | 0.012 | 0.0474 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.0249 | 0.0249 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0939 | 0.242 | 0.2786 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0085 | 0.012 | 0.0474 |
Plasmodium vivax | kinesin-5 | 0.0488 | 0.1206 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0249 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.0173 | 0.0681 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0085 | 0.012 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0013 | 0.0051 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0085 | 0.012 | 0.012 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0248 | 0.0559 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.0173 | 0.0681 |
Trypanosoma brucei | wee1-like protein kinase | 0.0248 | 0.0559 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0085 | 0.012 | 0.0139 |
Giardia lamblia | Kinesin-5 | 0.0488 | 0.1206 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0045 | 0.0013 | 0.0015 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0085 | 0.012 | 0.012 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.0249 | 0.098 |
Schistosoma mansoni | kinase | 0.0176 | 0.0365 | 0.042 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0045 | 0.0013 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0085 | 0.012 | 0.0474 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0085 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0013 | 0.0051 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0045 | 0.0013 | 0.0051 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0085 | 0.012 | 0.012 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0085 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0173 | 0.0681 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0085 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0084 | 0.0332 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0085 | 0.012 | 0.0474 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.0846 | 0.0974 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0488 | 0.1206 | 0.4745 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0085 | 0.012 | 0.0474 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0248 | 0.0559 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0085 | 0.012 | 0.012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0085 | 0.012 | 0.0474 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0085 | 0.012 | 0.0139 |
Schistosoma mansoni | protein kinase | 0.0524 | 0.1303 | 0.15 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0085 | 0.012 | 0.0474 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0085 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.012 | 0.0474 |
Echinococcus granulosus | FTZ F1 alpha | 0.0085 | 0.012 | 0.012 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0085 | 0.012 | 0.0474 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.0249 | 0.0249 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0013 | 0.0051 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED- | 0.0524 | 0.1303 | 0.5128 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0085 | 0.012 | 0.0139 |
Brugia malayi | steroid hormone receptor | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0013 | 0.0051 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0524 | 0.1303 | 0.1303 |
Brugia malayi | ecdysteroid receptor | 0.0085 | 0.012 | 0.0474 |
Echinococcus granulosus | geminin | 0.0354 | 0.0846 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.012 | 0.0474 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0249 | 0.0287 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0085 | 0.012 | 0.0474 |
Schistosoma mansoni | coup transcription factor | 0.0085 | 0.012 | 0.0139 |
Brugia malayi | Serine/threonine-protein kinase F42G10.2 | 0.0176 | 0.0365 | 0.1437 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0085 | 0.012 | 0.0139 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0045 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.0249 | 0.098 |
Entamoeba histolytica | kinesin, putative | 0.0488 | 0.1206 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | Kinesin motor domain containing protein | 0.0488 | 0.1206 | 0.4745 |
Echinococcus multilocularis | geminin | 0.0354 | 0.0846 | 0.0846 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0524 | 0.1303 | 0.5128 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0013 | 0.0051 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0085 | 0.012 | 0.0139 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.0846 | 0.0974 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.0249 | 0.098 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0084 | 0.0332 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0085 | 0.012 | 0.0139 |
Schistosoma mansoni | thyroid hormone receptor | 0.0085 | 0.012 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.012 | 0.0474 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0984 | 0.2541 | 0.2541 |
Schistosoma mansoni | hypothetical protein | 0.3268 | 0.8687 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0524 | 0.1303 | 0.1303 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0488 | 0.1206 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0524 | 0.1303 | 0.5128 |
Brugia malayi | nuclear receptor NHR-88 | 0.0085 | 0.012 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0013 | 0.0051 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0085 | 0.012 | 0.0139 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0085 | 0.012 | 0.0474 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0085 | 0.012 | 0.0474 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0984 | 0.2541 | 0.2541 |
Brugia malayi | RNA binding protein | 0.0132 | 0.0249 | 0.098 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0176 | 0.0365 | 0.0365 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0249 | 0.0287 |
Brugia malayi | Protein kinase domain containing protein | 0.0368 | 0.0882 | 0.3473 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0085 | 0.012 | 0.0474 |
Onchocerca volvulus | Kinase homolog | 0.0176 | 0.0365 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0984 | 0.2541 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0085 | 0.012 | 0.0474 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0248 | 0.0559 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0085 | 0.012 | 0.012 |
Onchocerca volvulus | 0.0085 | 0.012 | 0.33 | |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0248 | 0.0559 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0085 | 0.012 | 0.012 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0085 | 0.012 | 0.012 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0085 | 0.012 | 0.012 |
Brugia malayi | nuclear hormone receptor | 0.0085 | 0.012 | 0.0474 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0249 | 0.0287 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0045 | 0.0013 | 0.0013 |
Schistosoma mansoni | thyroid hormone receptor | 0.0085 | 0.012 | 0.0139 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0085 | 0.012 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.012 | 0.0474 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0248 | 0.0559 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0085 | 0.012 | 0.0139 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0085 | 0.012 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0013 | 0.0051 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0984 | 0.2541 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0084 | 0.0097 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0045 | 0.0013 | 0.0051 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.0173 | 0.0681 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.012 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.012 | 0.0474 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0085 | 0.012 | 0.33 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0085 | 0.012 | 0.012 |
Plasmodium falciparum | kinesin-5 | 0.0488 | 0.1206 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.0249 | 0.0287 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.0249 | 0.098 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0368 | 0.0882 | 0.3473 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0085 | 0.012 | 0.012 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0085 | 0.012 | 0.33 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0368 | 0.0882 | 0.1016 |
Schistosoma mansoni | kinesin eg-5 | 0.0488 | 0.1206 | 0.1388 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0045 | 0.0013 | 0.0015 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.0249 | 0.098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0085 | 0.012 | 0.0474 |
Loa Loa (eye worm) | STE/STE7/MEK4 protein kinase | 0.0176 | 0.0365 | 0.1437 |
Echinococcus multilocularis | kinesin family 1 | 0.3756 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0085 | 0.012 | 0.33 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 79 % | Binding affinity to mouse GAT1 stably transfected in HEK293 cells assessed as residual binding at 100 uM relative to control | ChEMBL. | 23859778 |
IC50 (binding) | = 4.23 | Inhibition of mouse GAT1-mediated [3H]GABA uptake stably transfected in HEK293 cells | ChEMBL. | 23859778 |
IC50 (binding) | = 4.4 | Inhibition of mouse GAT2-mediated [3H]GABA uptake stably transfected in HEK293 cells | ChEMBL. | 23859778 |
IC50 (binding) | = 4.49 | Inhibition of mouse GAT3-mediated [3H]GABA uptake stably transfected in HEK293 cells | ChEMBL. | 23859778 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.