Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.4371 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1247 | 0.4371 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0032 | 0.0004 | 0.001 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1247 | 0.4371 | 0.4371 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0588 | 0.2003 | 0.2003 |
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0014 | 0.0032 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0032 | 0.0004 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0016 | 0.5 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0588 | 0.2003 | 0.4583 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.0227 | 0.0519 |
Schistosoma mansoni | nuclear receptor | 0.0588 | 0.2003 | 0.2003 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | nuclear hormone receptor | 0.0588 | 0.2003 | 0.2003 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0093 | 0.0222 | 0.0508 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1247 | 0.4371 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1247 | 0.4371 | 0.4371 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0235 | 0.0733 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0211 | 0.0648 | 0.8837 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1247 | 0.4371 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0016 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0588 | 0.2003 | 0.2003 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0093 | 0.0222 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0211 | 0.0648 | 0.8837 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1247 | 0.4371 | 0.4371 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0014 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.4371 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0659 | 0.2257 | 0.2257 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0004 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.0157 | 0.0157 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0014 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0066 | 0.0151 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1247 | 0.4371 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | DR-78 | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0588 | 0.2003 | 0.2003 |
Brugia malayi | nuclear receptor NHR-88 | 0.0588 | 0.2003 | 0.4583 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0129 | 0.0295 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0659 | 0.2257 | 0.5163 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.2257 | 0.5163 |
Schistosoma mansoni | nuclear hormone receptor | 0.0588 | 0.2003 | 0.2003 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1247 | 0.4371 | 0.4371 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | ecdysteroid receptor | 0.1247 | 0.4371 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1247 | 0.4371 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | nuclear hormone receptor | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1247 | 0.4371 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0093 | 0.0222 | 0.0508 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0102 | 0.0233 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0014 | 0.0014 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0659 | 0.2257 | 0.5163 |
Brugia malayi | nuclear receptor RXR | 0.0659 | 0.2257 | 0.5163 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1247 | 0.4371 | 0.4371 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1247 | 0.4371 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0588 | 0.2003 | 0.4583 |
Mycobacterium tuberculosis | Probable reductase | 0.0211 | 0.0648 | 0.8837 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1247 | 0.4371 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0211 | 0.0648 | 0.8837 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.024 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0129 | 0.0129 |
Brugia malayi | conserved hypotetical protein | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | nuclear receptor RXR | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0588 | 0.2003 | 0.4583 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0014 | 0.0014 |
Echinococcus granulosus | FTZ F1 alpha | 0.1247 | 0.4371 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0032 | 0.0004 | 0.001 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0016 | 0.0037 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0093 | 0.0222 | 0.0508 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0016 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.024 | 0.0549 |
Brugia malayi | steroid hormone receptor | 0.1247 | 0.4371 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0093 | 0.0222 | 0.0508 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | zinc finger protein | 0.0588 | 0.2003 | 0.2003 |
Plasmodium vivax | glutathione reductase, putative | 0.0093 | 0.0222 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0093 | 0.0222 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0235 | 0.0733 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0235 | 0.0733 | 1 |
Schistosoma mansoni | coup transcription factor | 0.1247 | 0.4371 | 0.4371 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0032 | 0.0004 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0588 | 0.2003 | 0.4583 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1247 | 0.4371 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0211 | 0.0648 | 0.8837 |
Onchocerca volvulus | 0.1247 | 0.4371 | 1 | |
Schistosoma mansoni | nuclear hormone receptor | 0.1247 | 0.4371 | 0.4371 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0588 | 0.2003 | 0.4583 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0033 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.2257 | 0.5163 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1247 | 0.4371 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1247 | 0.4371 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1247 | 0.4371 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1247 | 0.4371 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0016 | 0.0016 |
Brugia malayi | hypothetical protein | 0.0659 | 0.2257 | 0.5163 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.0227 | 0.0519 |
Brugia malayi | nuclear receptor NHR-88 | 0.1247 | 0.4371 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0004 | 0.5 |
Brugia malayi | glutathione reductase | 0.0093 | 0.0222 | 0.0508 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1247 | 0.4371 | 0.4371 |
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.2257 | 0.5163 |
Toxoplasma gondii | thioredoxin reductase | 0.0093 | 0.0222 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0588 | 0.2003 | 0.4583 |
Trypanosoma brucei | trypanothione reductase | 0.0093 | 0.0222 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0307 | 0.0702 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.0227 | 0.0519 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0032 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.4371 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0016 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0093 | 0.0222 | 0.0508 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1247 | 0.4371 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1247 | 0.4371 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1247 | 0.4371 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0093 | 0.0222 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.1247 | 0.4371 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1247 | 0.4371 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0211 | 0.0648 | 0.8837 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | tailless protein | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.4371 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1247 | 0.4371 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1247 | 0.4371 | 0.4371 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0659 | 0.2257 | 0.5163 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0307 | 0.0702 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1247 | 0.4371 | 1 |
Brugia malayi | hypothetical protein | 0.0659 | 0.2257 | 0.5163 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1247 | 0.4371 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1247 | 0.4371 | 0.4371 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.024 | 0.0549 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0235 | 0.0733 | 1 |
Brugia malayi | ecdysone receptor | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1247 | 0.4371 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1247 | 0.4371 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1247 | 0.4371 | 0.4371 |
Brugia malayi | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0032 | 0.0004 | 0.0004 |
Plasmodium falciparum | glutathione reductase | 0.0093 | 0.0222 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0032 | 0.0004 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1247 | 0.4371 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1247 | 0.4371 | 0.4371 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0588 | 0.2003 | 0.4583 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1247 | 0.4371 | 0.4371 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0093 | 0.0222 | 0.2985 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0032 | 0.0004 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0016 | 0.0037 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0659 | 0.2257 | 0.2257 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0032 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Treponema pallidum | NADH oxidase | 0.0032 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.024 | 0.0549 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.2257 | 0.5163 |
Brugia malayi | nuclear receptor NHR-67 | 0.0588 | 0.2003 | 0.4583 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0033 | 0.0074 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0588 | 0.2003 | 0.4583 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0032 | 0.0004 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1247 | 0.4371 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1247 | 0.4371 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0016 | 0.0037 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0032 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0129 | 0.0295 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0659 | 0.2257 | 0.5163 |
Leishmania major | trypanothione reductase | 0.0093 | 0.0222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.2003 | 0.4583 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0659 | 0.2257 | 0.5163 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.2257 | 0.5163 |
Loa Loa (eye worm) | hypothetical protein | 0.1247 | 0.4371 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0307 | 0.0702 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1247 | 0.4371 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0014 | 0.0032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.