Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nicotinamide phosphoribosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Loa Loa (eye worm) | pre-B cell enhancing factor | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Brugia malayi | Pre-B cell enhancing factor precursor | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Schistosoma japonicum | ko:K03462 nicotinamide phosphoribosyltransferase [EC2.4.2.12], putative | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Schistosoma japonicum | ko:K03462 nicotinamide phosphoribosyltransferase [EC2.4.2.12], putative | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | phd finger protein, putative | 0.0206 | 0.1921 | 1 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0268 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0138 | 0.1054 | 0.0266 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0418 | 0.4659 | 0.4189 |
Schistosoma mansoni | enhancer of polycomb | 0.0126 | 0.0889 | 0.0987 |
Brugia malayi | PHD-finger family protein | 0.007 | 0.0174 | 0.0042 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0206 | 0.1921 | 1 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0078 | 0.0268 | 0.5 |
Schistosoma mansoni | phd finger protein | 0.0077 | 0.0268 | 0.0297 |
Echinococcus multilocularis | enhancer of polycomb | 0.0126 | 0.0889 | 0.0087 |
Echinococcus granulosus | enhancer of polycomb | 0.0126 | 0.0889 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1921 | 0.3834 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0138 | 0.1054 | 0.1931 |
Giardia lamblia | PHD finger protein 15 | 0.0206 | 0.1921 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0135 | 0.015 |
Echinococcus multilocularis | enhancer of polycomb | 0.0126 | 0.0889 | 0.0087 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0067 | 0.0135 | 0.015 |
Onchocerca volvulus | Alhambra homolog | 0.0206 | 0.1921 | 1 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0418 | 0.4659 | 0.5176 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0138 | 0.1054 | 0.0266 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0206 | 0.1921 | 0.3834 |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0268 | 1 |
Schistosoma mansoni | enhancer of polycomb | 0.0126 | 0.0889 | 0.0987 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0418 | 0.4659 | 0.4189 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0206 | 0.1921 | 0.121 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0206 | 0.1921 | 0.121 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.007 | 0.0174 | 0.0042 |
Brugia malayi | Bromodomain containing protein | 0.0779 | 0.9307 | 1 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.0418 | 0.4659 | 0.4932 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0418 | 0.4659 | 0.9846 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0423 | 0.4729 | 1 |
Schistosoma mansoni | enhancer of polycomb | 0.0126 | 0.0889 | 0.0987 |
Brugia malayi | Bromodomain containing protein | 0.0143 | 0.1114 | 0.1067 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0755 | 0.9001 | 1 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0268 | 0.0745 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0268 | 0.5 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.0078 | 0.0268 | 0.0298 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0206 | 0.1921 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0138 | 0.1054 | 0.1001 |
Brugia malayi | PHD-finger family protein | 0.0206 | 0.1921 | 0.1946 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0078 | 0.0268 | 0.5 |
Echinococcus multilocularis | peregrin | 0.0832 | 1 | 1 |
Echinococcus granulosus | enhancer of polycomb | 0.0126 | 0.0889 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1114 | 0.2063 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0078 | 0.0268 | 0.0298 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 0.1921 | 0.2134 |
Plasmodium vivax | hypothetical protein, conserved | 0.0206 | 0.1921 | 1 |
Schistosoma mansoni | transcription intermediary factor 1-related | 0.0119 | 0.0809 | 0.0899 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0078 | 0.0268 | 0.5 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0078 | 0.0268 | 0.5 |
Schistosoma mansoni | enhancer of polycomb | 0.0126 | 0.0889 | 0.0987 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4729 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.007 uM | Inhibition of Nampt (unknown origin) using NAM/PRPP as substrate preincubated for 15 mins measured after 30 mins | ChEMBL. | 23617784 |
IC50 (functional) | = 0.25 uM | Cytotoxicity against human A2780 cells after 72 hrs by SRB assay | ChEMBL. | 23617784 |
Stabilty (ADMET) | = 64 % | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins by LC-MS analysis | ChEMBL. | 23617784 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23617784 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.