TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 268.334 | Formula: C15H12N2OS
H donors: 1 H acceptors: 2 LogP: 3.05 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)C#Cc1nc2c(s1)C(=O)NCC2
InChi: 1S/C15H12N2OS/c1-10-3-2-4-11(9-10)5-6-13-17-12-7-8-16-15(18)14(12)19-13/h2-4,9H,7-8H2,1H3,(H,16,18)
InChiKey: SGJUSVUONBMZDQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, metabotropic 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	activin receptor type	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0321	0.3721	0.3721
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0321	0.3721	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0321	0.3721	0.3693
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0321	0.3721	0.3721
Schistosoma mansoni	shc transforming protein	0.0472	0.5735	0.5735
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0321	0.3721	0.3654
Onchocerca volvulus		0.0793	1	1
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654
Loa Loa (eye worm)	TK/ALK protein kinase	0.0321	0.3721	0.3654
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0321	0.3721	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0321	0.3721	0.3721
Echinococcus multilocularis	protein kinase	0.0321	0.3721	0.3721
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0326	0.3782	0.0097
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0472	0.5735	0.5735
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0472	0.5735	0.3207
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0321	0.3721	0.3721
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0472	0.5735	0.5716
Echinococcus granulosus	epidermal growth factor receptor	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus multilocularis	tensin	0.0472	0.5735	0.5735
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0321	0.3721	0.3693
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0326	0.3782	0.3716
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TK family protein kinase	0.0321	0.3721	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0321	0.3721	0.3721
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0472	0.5735	0.5716
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0321	0.3721	0.3721
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0472	0.5735	0.5689
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tensin	0.0472	0.5735	0.5735
Schistosoma mansoni	tyrosine kinase	0.0793	1	1
Trichomonas vaginalis	STE family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Brugia malayi	Tensin	0.0472	0.5735	0.5716
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0793	1	1
Echinococcus granulosus	hypothetical protein	0.0472	0.5735	0.5735
Toxoplasma gondii	protein kinase	0.0321	0.3721	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine kinase	0.0793	1	1
Echinococcus multilocularis	insulin receptor	0.0321	0.3721	0.3721
Brugia malayi	hypothetical protein	0.0321	0.3721	0.3693
Echinococcus multilocularis	SH2 domain containing protein 7	0.0472	0.5735	0.5735
Schistosoma mansoni	ephrin receptor	0.0321	0.3721	0.3721
Echinococcus granulosus	natriuretic peptide receptor 1	0.0321	0.3721	0.3721
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Schistosoma mansoni	serine/threonine RGC	0.0321	0.3721	0.3721
Onchocerca volvulus		0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Loa Loa (eye worm)	serine/threonine protein kinase	0.0321	0.3721	0.3654
Brugia malayi	SH2 domain containing protein	0.0472	0.5735	0.5716
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0472	0.5735	0.5716
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.006	0.0256	0.0256
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Brugia malayi	SRC-1	0.0793	1	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0321	0.3721	0.3693
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0793	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0793	1	1
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Echinococcus multilocularis	activated cdc42 kinase 1	0.0321	0.3721	0.3721
Schistosoma mansoni	adapter molecule crk	0.0472	0.5735	0.5735
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Schistosoma mansoni	hypothetical protein	0.0472	0.5735	0.5735
Loa Loa (eye worm)	TK/FER protein kinase	0.0321	0.3721	0.3654
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0793	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0321	0.3721	0.3721
Brugia malayi	SH2 domain containing protein	0.0472	0.5735	0.5716
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0472	0.5735	0.5716
Schistosoma mansoni	hypothetical protein	0.0472	0.5735	0.5735
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0472	0.5735	0.5735
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.3721	0.5
Echinococcus granulosus	protein kinase	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0472	0.5735	0.5735
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0321	0.3721	0.3721
Echinococcus granulosus	protein tyrosine kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0321	0.3721	0.3721
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0321	0.3721	0.5
Plasmodium vivax	protein kinase, putative	0.0321	0.3721	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0321	0.3721	0.3654
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0472	0.5735	0.5735
Echinococcus granulosus	kinase suppressor of Ras 1	0.0321	0.3721	0.3721
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0321	0.3721	0.3693
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0321	0.3721	0.3721
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0321	0.3721	0.3654
Brugia malayi	Tyrosine-protein kinase abl-1	0.0793	1	1
Echinococcus granulosus	metabotropic glutamate receptor 5	0.006	0.0256	0.0256
Brugia malayi	SH2 domain containing protein	0.0472	0.5735	0.5716
Brugia malayi	Variant SH3 domain containing protein	0.0472	0.5735	0.5716
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0472	0.5735	0.5735
Echinococcus multilocularis	integrin linked protein kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0321	0.3721	0.5
Echinococcus multilocularis	SH2 motif	0.0472	0.5735	0.5735
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0321	0.3721	0.3721
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0321	0.3721	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0472	0.5735	0.5735
Echinococcus multilocularis	protein kinase	0.0321	0.3721	0.3721
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Brugia malayi	Variant SH3 domain containing protein	0.0472	0.5735	0.5716
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Onchocerca volvulus		0.0793	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0472	0.5735	0.5716
Brugia malayi	SH2 domain containing protein	0.0793	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0321	0.3721	0.3654
Brugia malayi	Protein kinase domain containing protein	0.0793	1	1
Leishmania major	protein kinase, putative	0.0321	0.3721	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0321	0.3721	0.3721
Schistosoma mansoni	protein tyrosine kinase	0.0321	0.3721	0.3721
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0472	0.5735	0.5716
Loa Loa (eye worm)	TK/FER protein kinase	0.0321	0.3721	0.3654
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0472	0.5735	0.5735
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0472	0.5735	0.5689
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine protein kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	epidermal growth factor receptor	0.0321	0.3721	0.3721
Brugia malayi	hypothetical protein	0.0793	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Onchocerca volvulus		0.0472	0.5735	0.3207
Echinococcus granulosus	tyrosine protein kinase Blk	0.0793	1	1
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0321	0.3721	0.3654
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0793	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0472	0.5735	0.5735
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Loa Loa (eye worm)	TK/FER protein kinase	0.0321	0.3721	0.3654
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0472	0.5735	0.5735
Trichomonas vaginalis	CAMK family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0472	0.5735	0.5689
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0793	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0256	0.0152
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0321	0.3721	0.3654
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654
Schistosoma mansoni	suppressor of cytokine signaling	0.0472	0.5735	0.5735
Schistosoma mansoni	suppressor of cytokine signaling	0.0472	0.5735	0.5735
Schistosoma mansoni	serine/threonine protein kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	signal transduction protein lnk realted	0.0472	0.5735	0.5735
Echinococcus multilocularis	tyrosine protein kinase csk	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0321	0.3721	0.3721
Loa Loa (eye worm)	TK/DDR protein kinase	0.0321	0.3721	0.3654
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0321	0.3721	0.3693
Echinococcus granulosus	insulin receptor	0.0321	0.3721	0.3721
Loa Loa (eye worm)	TK/FER protein kinase	0.0321	0.3721	0.3654
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0321	0.3721	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0472	0.5735	0.5735
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0321	0.3721	0.3654
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.3721	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0793	1	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0321	0.3721	0.3721
Toxoplasma gondii	STE kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	NCK adaptor protein	0.0472	0.5735	0.5735
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0793	1	1
Schistosoma mansoni	ephrin receptor	0.0321	0.3721	0.3721
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0793	1	1
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Schistosoma mansoni	serine/threonine protein kinase	0.0321	0.3721	0.3721
Echinococcus multilocularis	N chimaerin	0.0472	0.5735	0.5735
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.3721	0.5
Plasmodium falciparum	protein kinase, putative	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0321	0.3721	0.5
Onchocerca volvulus		0.0472	0.5735	0.3207
Brugia malayi	RhoGAP domain containing protein	0.0472	0.5735	0.5716
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0472	0.5735	0.5689
Loa Loa (eye worm)	TK/ABL protein kinase	0.0793	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine kinase	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.0195	0.0195
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Echinococcus multilocularis	tyrosine protein kinase csk	0.0321	0.3721	0.3721
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0321	0.3721	0.3654
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0472	0.5735	0.5735
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0321	0.3721	0.5
Onchocerca volvulus		0.0793	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0472	0.5735	0.5689
Schistosoma mansoni	tyrosine kinase	0.0793	1	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0472	0.5735	0.5735
Brugia malayi	Protein kinase domain containing protein	0.0793	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Onchocerca volvulus		0.0472	0.5735	0.3207
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654
Loa Loa (eye worm)	TK/CSK protein kinase	0.0321	0.3721	0.3654
Loa Loa (eye worm)	TK/FER protein kinase	0.0321	0.3721	0.3654
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0472	0.5735	0.5689
Entamoeba histolytica	protein kinase, putative	0.0472	0.5735	0.3207
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK protein kinase	0.0793	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.3721	0.5
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Echinococcus multilocularis	activin receptor type	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Echinococcus multilocularis	tensin	0.0472	0.5735	0.5735
Echinococcus multilocularis	heat shock protein 70	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine protein kinase csk	0.0321	0.3721	0.3721
Trichomonas vaginalis	protein kinase atn1, putative	0.0321	0.3721	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0321	0.3721	0.3721
Trypanosoma cruzi	protein kinase, putative	0.0321	0.3721	0.5
Loa Loa (eye worm)	hypothetical protein	0.0793	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0321	0.3721	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0472	0.5735	0.5735
Loa Loa (eye worm)	SRC-1	0.0793	1	1
Brugia malayi	integrin-linked kinase	0.0321	0.3721	0.3693
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Echinococcus granulosus	tyrosine kinase	0.0326	0.3782	0.3782
Loa Loa (eye worm)	TK/INSR protein kinase	0.0321	0.3721	0.3654
Brugia malayi	ephrin receptor 1 precursor	0.0321	0.3721	0.3693
Schistosoma mansoni	growth factor receptor-bound protein	0.0472	0.5735	0.5735
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0321	0.3721	0.3721
Brugia malayi	SH2 domain containing protein	0.0472	0.5735	0.5716
Echinococcus granulosus	tyrosine kinase	0.0793	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0321	0.3721	0.3721
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.0105	0.0061
Echinococcus multilocularis	protein tyrosine kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0326	0.3782	0.3716
Giardia lamblia	Protein 21.1	0.0321	0.3721	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0326	0.3782	0.3782
Echinococcus granulosus	tyrosine protein kinase HCK	0.0321	0.3721	0.3721
Loa Loa (eye worm)	TK/EPH protein kinase	0.0321	0.3721	0.3654
Schistosoma mansoni	GTPase activating protein	0.0472	0.5735	0.5735
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0321	0.3721	0.5
Echinococcus multilocularis	NCK adaptor protein	0.0472	0.5735	0.5735
Brugia malayi	Raf kinase	0.0321	0.3721	0.3693
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0472	0.5735	0.5735
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0793	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0321	0.3721	0.5
Echinococcus multilocularis	SH2 motif	0.0472	0.5735	0.5735
Schistosoma mansoni	nck2/grb4	0.0472	0.5735	0.5735
Trypanosoma brucei	protein kinase, putative	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0793	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0793	1	1
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Trypanosoma brucei	Pseudokinase, putative	0.0321	0.3721	0.5
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0321	0.3721	0.3693
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0472	0.5735	0.5689
Schistosoma mansoni	serine/threonine protein kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.3721	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0321	0.3721	0.5
Onchocerca volvulus		0.0472	0.5735	0.3207
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Brugia malayi	Receptor family ligand binding region containing protein	0.0326	0.3782	0.3754
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Schistosoma mansoni	vav2	0.0472	0.5735	0.5735
Echinococcus multilocularis	FL cytokine receptor	0.0321	0.3721	0.3721
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0793	1	1
Schistosoma mansoni	tyrosine kinase	0.0326	0.3782	0.3782
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0321	0.3721	0.3693
Entamoeba histolytica	SH2 domain containing protein	0.0472	0.5735	0.3207
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0321	0.3721	0.3721
Echinococcus granulosus	integrin linked protein kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine kinase	0.0793	1	1
Schistosoma mansoni	tyrosine kinase	0.0793	1	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0321	0.3721	0.3654
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0472	0.5735	0.5735
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0321	0.3721	0.3654
Brugia malayi	SH2 domain containing protein	0.0472	0.5735	0.5716
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0472	0.5735	0.5735
Loa Loa (eye worm)	TK/Met protein kinase	0.0321	0.3721	0.3654
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine protein kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	expressed conserved protein	0.0472	0.5735	0.5735
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Brugia malayi	Tyrosine-protein kinase PR2	0.0321	0.3721	0.3693
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0321	0.3721	0.3721
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0472	0.5735	0.5735
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0793	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0321	0.3721	0.3654
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus multilocularis	tyrosine kinase	0.0326	0.3782	0.3782
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0793	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0472	0.5735	0.5735
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0793	1	1
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Leishmania major	protein kinase, putative	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine kinase	0.0326	0.3782	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0472	0.5735	0.5735
Trypanosoma cruzi	protein kinase, putative	0.0321	0.3721	0.5
Schistosoma mansoni	tensin-related	0.0472	0.5735	0.5735
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0321	0.3721	0.3654
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0472	0.5735	0.5735
Brugia malayi	protein-tyrosine kinase	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0321	0.3721	0.5
Plasmodium falciparum	protein kinase, putative	0.0321	0.3721	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	tensin	0.0472	0.5735	0.5735
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0793	1	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0793	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.3721	0.5
Leishmania major	hypothetical protein, conserved	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0321	0.3721	0.3654
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0793	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0793	1	1
Onchocerca volvulus		0.0472	0.5735	0.3207
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0321	0.3721	0.3721
Echinococcus multilocularis	SHC transforming protein 3	0.0472	0.5735	0.5735
Giardia lamblia	Kinase, NEK	0.0321	0.3721	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0472	0.5735	0.5735
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0321	0.3721	0.3654
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0793	1	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0321	0.3721	0.3721
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0321	0.3721	0.3721
Echinococcus granulosus	activated cdc42 kinase 1	0.0321	0.3721	0.3721
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0472	0.5735	0.3207
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0793	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0326	0.3782	0.3782
Echinococcus multilocularis	tyrosine protein kinase csk	0.0321	0.3721	0.3721
Brugia malayi	SH2 domain containing protein	0.0472	0.5735	0.5716
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Schistosoma mansoni	tensin	0.0472	0.5735	0.5735
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0793	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0472	0.5735	0.5735
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0321	0.3721	0.3721
Loa Loa (eye worm)	SH2 domain-containing protein	0.0472	0.5735	0.5689
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Echinococcus multilocularis	transfer RNA-Thr	0.0321	0.3721	0.3721
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tensin-related	0.0472	0.5735	0.5735
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine protein kinase Srms	0.0793	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0472	0.5735	0.5735
Schistosoma mansoni	tyrosine kinase	0.0793	1	1
Echinococcus granulosus	SH2 motif	0.0472	0.5735	0.5735
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Loa Loa (eye worm)	hypothetical protein	0.0321	0.3721	0.3654
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0321	0.3721	0.3693
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Schistosoma mansoni	hypothetical protein	0.0321	0.3721	0.3721
Onchocerca volvulus		0.0793	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0321	0.3721	0.3721
Loa Loa (eye worm)	STAT protein	0.0472	0.5735	0.5689
Schistosoma mansoni	protein kinase	0.0321	0.3721	0.3721
Brugia malayi	SH2 domain containing protein	0.0793	1	1
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Brugia malayi	Protein kinase domain containing protein	0.0793	1	1
Echinococcus multilocularis		0.0472	0.5735	0.5735
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0321	0.3721	0.3721
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0793	1	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0321	0.3721	0.3654
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Brugia malayi	Protein kinase domain containing protein	0.0793	1	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0321	0.3721	0.3721
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0321	0.3721	0.3693
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0472	0.5735	0.5735
Schistosoma mansoni	SH2A	0.0472	0.5735	0.5735
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0793	1	1
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.0326	0.3782	0.3754
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tensin	0.0472	0.5735	0.5735
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0472	0.5735	0.5735
Echinococcus granulosus	SH2 motif	0.0472	0.5735	0.5735
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0321	0.3721	0.3721
Brugia malayi	SH2 domain containing protein	0.0472	0.5735	0.5716
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0472	0.5735	0.3207
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654
Brugia malayi	hypothetical protein	0.0321	0.3721	0.3693
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0321	0.3721	0.3654
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0472	0.5735	0.5735
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0321	0.3721	0.3693
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Onchocerca volvulus		0.0472	0.5735	0.3207
Brugia malayi	Variant SH3 domain containing protein	0.0472	0.5735	0.5716
Loa Loa (eye worm)	hypothetical protein	0.0472	0.5735	0.5689
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0321	0.3721	0.3693
Echinococcus multilocularis	tyrosine protein kinase shark	0.0793	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0321	0.3721	0.3721
Onchocerca volvulus		0.0326	0.3782	0.0097
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Echinococcus multilocularis	SH2 motif	0.0472	0.5735	0.5735
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0321	0.3721	0.3721
Giardia lamblia	Kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0321	0.3721	0.3721
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0472	0.5735	0.5735
Echinococcus granulosus	N chimaerin	0.0472	0.5735	0.5735
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654
Brugia malayi	Protein kinase domain containing protein	0.0321	0.3721	0.3693
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0472	0.5735	0.5689
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0321	0.3721	0.3721
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0321	0.3721	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0326	0.3782	0.3716
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0321	0.3721	0.3654
Loa Loa (eye worm)	TK/FER protein kinase	0.0793	1	1
Schistosoma mansoni	tyrosine kinase	0.0793	1	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0321	0.3721	0.3721
Onchocerca volvulus		0.0793	1	1
Schistosoma mansoni	protein kinase	0.0326	0.3782	0.3782
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0472	0.5735	0.5735
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Schistosoma mansoni	tyrosine kinase	0.0321	0.3721	0.3721
Schistosoma mansoni	serine/threonine protein kinase	0.0321	0.3721	0.3721
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0472	0.5735	0.5735
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0321	0.3721	0.3721
Echinococcus granulosus	tyrosine protein kinase shark	0.0793	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0793	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0321	0.3721	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0326	0.3782	0.3716
Plasmodium falciparum	protein kinase, putative	0.0321	0.3721	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0472	0.5735	0.5735
Echinococcus granulosus	c src tyrosine kinase	0.0793	1	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0321	0.3721	0.3721
Brugia malayi	hypothetical protein	0.0472	0.5735	0.5716
Giardia lamblia	Kinase, NEK	0.0321	0.3721	0.5
Loa Loa (eye worm)	TK protein kinase	0.0321	0.3721	0.3654

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	> 10000 nM	Positive allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as potentiation of L-glutamate-induced activity after 1 hr by FLIPR assay	ChEMBL.	23770058
Emax (binding)	= 50 %	Positive allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as potentiation of L-glutamate-induced activity after 1 hr by FLIPR assay relative to control	ChEMBL.	23770058
IC50 (binding)	> 10000 nM	Negative allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-glutamate-induced activity after 1 hr by FLIPR assay	ChEMBL.	23770058
Inhibition (binding)	= -22 %	Negative allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-glutamate-induced activity after 1 hr by FLIPR assay relative to control	ChEMBL.	23770058

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2403665

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1778913