Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Quinolone resistance protein norA | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Leishmania braziliensis | hypothetical protein, conserved | Get druggable targets OG5_134723 | All targets in OG5_134723 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0248 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0248 | 1 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0158 | 0 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0248 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0248 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0248 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0248 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0248 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0248 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0248 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0158 | 0 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0158 | 0 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0248 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0248 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0248 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0248 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0248 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0158 | 0 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0158 | 0 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0158 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0248 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0248 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14.8 uM | Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux measured for 5 mins by fluorometric analysis | ChEMBL. | 23710549 |
Inhibition (binding) | = 91.3 % | Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux at 50 uM measured for 5 mins by fluorometric analysis relative to control | ChEMBL. | 23710549 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.