Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | purinergic receptor P2Y, G-protein coupled, 1 | 373 aa | 393 aa | 17.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0453 | 0.7831 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0453 | 0.7831 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0126 | 0.1806 | 0.2307 |
Leishmania major | biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 | 0.0518 | 0.9036 | 0.9036 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0453 | 0.7831 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.033 | 0.5576 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.033 | 0.5576 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0453 | 0.7831 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.033 | 0.5576 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.033 | 0.5576 | 0.5607 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0453 | 0.7831 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0126 | 0.1806 | 0.2307 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.006 | 0.0595 | 0.1067 |
Toxoplasma gondii | redoxin domain-containing protein | 0.0099 | 0.1325 | 0.2377 |
Brugia malayi | dihydrofolate reductase family protein | 0.0453 | 0.7831 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.033 | 0.5576 | 0.5576 |
Schistosoma mansoni | dihydrofolate reductase | 0.0453 | 0.7831 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.006 | 0.0595 | 0.0759 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0453 | 0.7831 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.033 | 0.5576 | 1 |
Brugia malayi | thymidylate synthase | 0.0126 | 0.1806 | 0.1674 |
Onchocerca volvulus | 0.0126 | 0.1806 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.006 | 0.0595 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0453 | 0.7831 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0568 | 0.9945 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0453 | 0.7831 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 45 nM | Displacement of [beta-33P]-2MeS-ADP from human P2Y1 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysis | ChEMBL. | 23668989 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.