Detailed view for LmjF.35.5150

Basic information

TDR Targets ID: 28578
Leishmania major, biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.1515 | Length (AA): 631 | MW (Da): 69606 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 14

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03092   BT1 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
190 582 1ots (A) 33 436 12.00 0.000014 0.08 0.69 -1.29
13 91 2imr (A) 90 171 32.00 0.29 0.13 0.246498 1.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_184119)

Species Accession Gene Product
Leishmania braziliensis LbrM.34.5090   biopterin transporter, putative
Leishmania donovani LdBPK_355120.1   biopterin transporter, putative
Leishmania infantum LinJ.35.5120   biopterin transporter, putative
Leishmania major LmjF.35.5150   biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120
Leishmania mexicana LmxM.34.5150   biopterin transporter, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) drug sensitive (PATO:0000529) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania tarentolae 1763   48945   59943   547983   572016   572017  
Annotator: crowther@u.washington.edu. Comment: deletion of biopterin transport gene led to hypersensitivity to methotrexate. References: 14981076

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0441 0.7522 0.7515
0.0441 0.7522 0.7515
0.0474 0.7438 0.7438
0.049 0.6401 0.8005
0.0191 0.6379 0.6361
0.0632 0.8009 0.8005
0.0472 0.7531 0.7531
0.0371 0.7506 0.7467
0.0207 0.6364 0.6364
0.0518 0.9036 0.9036
0.0373 0.7522 0.7515
0.0439 0.545 0.8005
0.0373 0.7522 0.7515
0.0276 0.5855 0.752
0.0599 0.7532 0.7532
0.0521 0.6222 0.6222
0.034 0.7523 0.7523
0.0511 0.8888 0.7821

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LmjF.35.5150 (Leishmania major), biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120
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