Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 binding protein 1 | Starlite/ChEMBL | References |
Homo sapiens | PHD finger protein 23 | Starlite/ChEMBL | References |
Homo sapiens | lysine (K)-specific demethylase 5A | Starlite/ChEMBL | References |
Homo sapiens | ubiquitin-like with PHD and ring finger domains 1 | Starlite/ChEMBL | References |
Homo sapiens | mbt domain containing 1 | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 3 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | chromobox homolog 7 | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | l(3)mbt-like 4 (Drosophila) | Starlite/ChEMBL | References |
Homo sapiens | Scm-like with four mbt domains 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | polycomb protein SCMH1 | 0.0318 | 0.2828 | 0.4682 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0111 | 0.0735 | 0.1089 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0115 | 0.0769 | 0.1147 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0461 | 0.4271 | 0.7161 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0318 | 0.2828 | 0.2754 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0115 | 0.0769 | 0.1147 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0093 | 0.0547 | 0.0766 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0331 | 0.2959 | 0.5001 |
Toxoplasma gondii | PLU-1 family protein | 0.0053 | 0.014 | 1 |
Schistosoma mansoni | chromobox protein | 0.0236 | 0.1996 | 0.1914 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.0735 | 0.064 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0115 | 0.0769 | 0.1147 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0392 | 0.3573 | 0.5962 |
Echinococcus granulosus | chromobox protein 2 | 0.0236 | 0.1996 | 0.3253 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0547 | 0.5147 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0392 | 0.3573 | 0.3507 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0137 | 0.0991 | 0.1527 |
Echinococcus multilocularis | chromobox protein 2 | 0.0236 | 0.1996 | 0.3253 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0111 | 0.0735 | 0.064 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0624 | 0.5924 | 1 |
Brugia malayi | mbt repeat family protein | 0.0547 | 0.5147 | 1 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0137 | 0.0991 | 0.1527 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0164 | 0.1268 | 0.1139 |
Brugia malayi | jmjC domain containing protein | 0.0164 | 0.1268 | 0.1139 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0115 | 0.0769 | 0.0674 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0461 | 0.4271 | 0.4212 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0624 | 0.5924 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0461 | 0.4271 | 0.7161 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.5147 | 1 |
Brugia malayi | mbt repeat family protein | 0.0331 | 0.2959 | 0.5001 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0392 | 0.3573 | 0.5962 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0318 | 0.2828 | 0.2754 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0318 | 0.2828 | 0.4682 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0115 | 0.0769 | 0.1147 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.22 uM | Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assay | ChEMBL. | 24040942 |
IC50 (binding) | = 0.23 uM | Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | = 6.8 uM | Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of L3MBTL4 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of JARID1A (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of PHF23 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of UHRF1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of CBX7 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of MBTD1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
IC50 (binding) | > 10 uM | Inhibition of SFMBT1 (unknown origin) after 30 mins by AlphaScreen assay | ChEMBL. | 24040942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.