TDR Targets

Basic information

Technical information

TDR Targets ID: 178322
Name: 7-(3-bromo-4-fluorophenyl)-5-methyl-1,1-dioxo -2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-ca rboxylic acid
MW: 402.235 | Formula: C15H13BrFNO4S
H donors: 2 H acceptors: 4 LogP: 2.07 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC1=C(C(=O)O)C(C2=C(N1)CCS2(=O)=O)c1ccc(c(c1)Br)F
InChi: 1S/C15H13BrFNO4S/c1-7-12(15(19)20)13(8-2-3-10(17)9(16)6-8)14-11(18-7)4-5-23(14,21)22/h2-3,6,13,18H,4-5H2,1H3,(H,19,20)
InChiKey: PKFRJISEUHGODA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-(3-bromo-4-fluoro-phenyl)-5-methyl-1,1-dioxo-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylic acid
7-(3-bromo-4-fluoro-phenyl)-1,1-diketo-5-methyl-2,3,4,7-tetrahydrothieno[3,2-b]pyridine-6-carboxylic acid
7-(3-bromo-4-fluorophenyl)-5-methyl-1,1-dioxo-2,3,4,7-tetrahydrothieno[2,3-e]pyridine-6-carboxylic acid
7-(3-bromo-4-fluoro-phenyl)-5-methyl-1,1-dioxo-2,3,4,7-tetrahydrothieno[2,3-e]pyridine-6-carboxylic acid
7-(3-bromo-4-fluoro-phenyl)-1,1-diketo-5-methyl-2,3,4,7-tetrahydrothieno[2,3-e]pyridine-6-carboxylic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium inwardly-rectifying channel, subfamily J, member 11	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0237	0.1203	1
Brugia malayi	nuclear receptor RXR	0.039	0.2104	0.5075
Brugia malayi	conserved hypotetical protein	0.0349	0.1859	0.4485
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0213	0.1064	0.8837
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0739	0.4145	1
Brugia malayi	Nuclear hormone receptor-like 1	0.039	0.2104	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0212	0.051
Entamoeba histolytica	hypothetical protein	0.0035	0.0025	0.5
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0102	0.0415	0.1002
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0051	0.0123
Plasmodium falciparum	thioredoxin reductase	0.0093	0.0364	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0032	0.0007	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0105	0.0254
Entamoeba histolytica	hypothetical protein	0.0035	0.0025	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.039	0.2104	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0739	0.4145	0.4145
Echinococcus granulosus	FTZ F1 alpha	0.0739	0.4145	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0349	0.1859	0.4485
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0739	0.4145	1
Brugia malayi	ecdysone receptor	0.0349	0.1859	0.4485
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0349	0.1859	0.4485
Toxoplasma gondii	hypothetical protein	0.0102	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Schistosoma mansoni	zinc finger protein	0.0349	0.1859	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Loa Loa (eye worm)	nuclear hormone receptor	0.0349	0.1859	0.4485
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0739	0.4145	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0739	0.4145	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0739	0.4145	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.2104	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4145	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0394	0.095
Brugia malayi	Thioredoxin reductase	0.0093	0.0364	0.0878
Schistosoma mansoni	nuclear receptor nhr-48	0.0349	0.1859	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Brugia malayi	tailless protein	0.0349	0.1859	0.4485
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0025	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0739	0.4145	1
Onchocerca volvulus	Bile acid receptor homolog	0.0739	0.4145	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0739	0.4145	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0032	0.0007	0.0017
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0021	0.0021
Brugia malayi	hypothetical protein	0.039	0.2104	0.5075
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0349	0.1859	0.4485
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Echinococcus multilocularis	ecdysone induced protein 78C	0.0739	0.4145	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.039	0.2104	0.2104
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0349	0.1859	0.4485
Brugia malayi	nuclear hormone receptor family member odr-7	0.0349	0.1859	0.4485
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0739	0.4145	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.039	0.2104	0.2104
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.039	0.2104	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Brugia malayi	nuclear hormone receptor	0.0739	0.4145	1
Brugia malayi	nuclear hormone receptor	0.0349	0.1859	0.4485
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0415	0.1002
Brugia malayi	nuclear receptor NHR-67	0.0349	0.1859	0.4485
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4145	1
Brugia malayi	jmjC domain containing protein	0.0035	0.0021	0.005
Loa Loa (eye worm)	glutathione reductase	0.0093	0.0364	0.0878
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0739	0.4145	1
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4145	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0349	0.1859	0.4485
Leishmania major	trypanothione reductase	0.0093	0.0364	1
Trichomonas vaginalis	glutathione reductase, putative	0.0032	0.0007	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0739	0.4145	1
Loa Loa (eye worm)	steroid hormone receptor	0.0739	0.4145	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0415	0.1002
Echinococcus granulosus	nuclear receptor nhr 48	0.0349	0.1859	0.4485
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0021	0.005
Mycobacterium tuberculosis	Probable reductase	0.0213	0.1064	0.8837
Entamoeba histolytica	hypothetical protein	0.0035	0.0025	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.051	0.1231
Brugia malayi	hypothetical protein	0.039	0.2104	0.5075
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0739	0.4145	1
Trichomonas vaginalis	mercuric reductase, putative	0.0032	0.0007	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0349	0.1859	0.4485
Schistosoma mansoni	retinoic acid receptor RXR	0.0739	0.4145	0.4145
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0739	0.4145	1
Schistosoma mansoni	nuclear receptor	0.0349	0.1859	0.1859
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0349	0.1859	0.4485
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0032	0.0007	0.5
Loa Loa (eye worm)	thioredoxin reductase	0.0093	0.0364	0.0878
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0739	0.4145	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0213	0.1064	0.8837
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0349	0.1859	0.4485
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0213	0.1064	0.8837
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0739	0.4145	0.4145
Schistosoma mansoni	RAR-like nuclear receptor	0.0739	0.4145	0.4145
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Mycobacterium tuberculosis	Probable oxidoreductase	0.0237	0.1203	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0739	0.4145	1
Schistosoma mansoni	hypothetical protein	0.0067	0.0212	0.0212
Entamoeba histolytica	hypothetical protein	0.0035	0.0025	0.5
Plasmodium falciparum	glutathione reductase	0.0093	0.0364	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0093	0.0364	1
Brugia malayi	Steroid receptor seven-up type 2	0.0739	0.4145	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0349	0.1859	0.4485
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0739	0.4145	1
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0032	0.0007	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.039	0.2104	0.5075
Toxoplasma gondii	thioredoxin reductase	0.0093	0.0364	0.8747
Brugia malayi	nuclear receptor NHR-88	0.0349	0.1859	0.4485
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0394	0.095
Echinococcus granulosus	ecdysone induced protein 78C	0.0739	0.4145	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0032	0.0007	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0394	0.095
Brugia malayi	hypothetical protein	0.0349	0.1859	0.4485
Onchocerca volvulus		0.0739	0.4145	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0025	0.0025
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0032	0.0007	0.0007
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0349	0.1859	0.4485
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0032	0.0007	0.0017
Echinococcus multilocularis	FTZ F1 alpha	0.0739	0.4145	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0739	0.4145	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0739	0.4145	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0025	0.006
Schistosoma mansoni	nuclear receptor	0.0349	0.1859	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0021	0.005
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4145	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0349	0.1859	0.4485
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0032	0.0007	0.5
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.0367	0.0885
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0032	0.0007	0.5
Brugia malayi	MH2 domain containing protein	0.0118	0.051	0.1231
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.051	0.1231
Schistosoma mansoni	coup transcription factor	0.0739	0.4145	0.4145
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0739	0.4145	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0739	0.4145	0.4145
Echinococcus granulosus	thioredoxin glutathione reductase	0.0093	0.0364	0.0878
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0739	0.4145	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0739	0.4145	1
Schistosoma mansoni	nuclear hormone receptor	0.0739	0.4145	0.4145
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4145	1
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4145	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0739	0.4145	1
Plasmodium vivax	glutathione reductase, putative	0.0093	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0164	0.0396
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0739	0.4145	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0213	0.1064	0.8837
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0212	0.051
Schistosoma mansoni	nuclear hormone receptor	0.0349	0.1859	0.1859
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0739	0.4145	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0093	0.0364	0.2985
Loa Loa (eye worm)	hypothetical protein	0.039	0.2104	0.5075
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0739	0.4145	1
Loa Loa (eye worm)	DR-78	0.0349	0.1859	0.4485
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0739	0.4145	1
Brugia malayi	nuclear receptor NHR-88	0.0739	0.4145	1
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.0254	0.0254
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0739	0.4145	1
Schistosoma mansoni	nuclear hormone receptor	0.0349	0.1859	0.1859
Mycobacterium tuberculosis	Probable dehydrogenase	0.0213	0.1064	0.8837
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0051	0.0123
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0237	0.1203	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0739	0.4145	0.4145
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0739	0.4145	0.4145
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.0394	0.095
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0739	0.4145	1
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4145	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0349	0.1859	0.4485
Brugia malayi	nuclear receptor RXR	0.0349	0.1859	0.4485
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0093	0.0364	0.0878
Schistosoma mansoni	thyroid hormone receptor	0.0739	0.4145	0.4145
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0032	0.0007	0.5
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Plasmodium vivax	thioredoxin reductase, putative	0.0093	0.0364	1
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4145	1
Brugia malayi	hypothetical protein	0.0035	0.0025	0.006
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0021	0.005
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0739	0.4145	0.4145
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0739	0.4145	1
Brugia malayi	steroid hormone receptor	0.0739	0.4145	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0739	0.4145	1
Brugia malayi	Nuclear hormone receptor E75	0.0349	0.1859	0.4485
Brugia malayi	glutathione reductase	0.0093	0.0364	0.0878
Brugia malayi	orphan nuclear receptor NR2E1	0.0349	0.1859	0.4485
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0349	0.1859	0.4485
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0349	0.1859	0.1859
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0739	0.4145	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0739	0.4145	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0739	0.4145	1
Trypanosoma brucei	trypanothione reductase	0.0093	0.0364	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0739	0.4145	1
Schistosoma mansoni	thyroid hormone receptor	0.0739	0.4145	0.4145
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0349	0.1859	0.4485
Brugia malayi	Nuclear hormone receptor E75	0.0349	0.1859	0.4485
Brugia malayi	photoreceptor-specific nuclear receptor	0.0739	0.4145	1
Brugia malayi	ecdysteroid receptor	0.0739	0.4145	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0739	0.4145	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.2104	0.5075
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0739	0.4145	0.4145
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0415	0.1002
Brugia malayi	jmjC domain containing protein	0.0094	0.0367	0.0885
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0032	0.0007	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0739	0.4145	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.0367	0.0885
Treponema pallidum	NADH oxidase	0.0032	0.0007	0.5
Loa Loa (eye worm)	hypothetical protein	0.039	0.2104	0.5075
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0739	0.4145	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0349	0.1859	0.4485
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0237	0.1203	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0349	0.1859	0.4485
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0739	0.4145	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.2104	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1859	0.4485
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.039	0.2104	0.5075
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0025	0.0025

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= -5.74	Evaluated for K-ATP activity in terms of change in membrane potential through guinea pig bladder assay	ChEMBL.	15163196
EC50 (functional)	= -5.06	Evaluated for K-ATP activity in terms of stable twitch response through field-stimulated landrace pig detrusor assay	ChEMBL.	15163196
Log EC50 (functional)	= 5.06	Evaluated for K-ATP activity in terms of stable twitch response through field-stimulated landrace pig detrusor assay	ChEMBL.	15163196
Log EC50 (functional)	= 5.74	Evaluated for K-ATP activity in terms of change in membrane potential through guinea pig bladder assay	ChEMBL.	15163196

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11165538

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 178322