Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | amine oxidase | 0.0057 | 0.0361 | 0.3607 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0617 | 0.6832 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0057 | 0.0361 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1002 | 0.1002 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0057 | 0.0361 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0058 | 0.0383 | 0.0383 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0057 | 0.0361 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0058 | 0.0383 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0057 | 0.0361 | 0.5 |
Echinococcus multilocularis | 0.0057 | 0.0361 | 0.3607 | |
Onchocerca volvulus | CoRest homolog | 0.0891 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0057 | 0.0361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0361 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.0383 |
Echinococcus granulosus | REST corepressor 3 | 0.0025 | 0 | 0.0002 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0057 | 0.0361 | 0.5 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0865 | 0.9708 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0058 | 0.0383 | 0.0383 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0058 | 0.0383 | 0.3818 |
Schistosoma mansoni | amine oxidase | 0.0057 | 0.0361 | 0.3607 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.0383 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0057 | 0.0361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.9708 | 0.9708 |
Echinococcus multilocularis | rest corepressor (corest) protein | 0.0025 | 0 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.107 | 0.107 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.056 | 0.6178 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0617 | 0.6832 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0429 | 0.0429 |
Onchocerca volvulus | 0.0118 | 0.107 | 0.107 | |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0112 | 0.1002 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0057 | 0.0361 | 0.3607 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0062 | 0.0429 | 0.0442 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0057 | 0.0361 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0058 | 0.0383 | 0.3818 |
Onchocerca volvulus | 0.0058 | 0.0383 | 0.0383 | |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0057 | 0.0361 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0057 | 0.0361 | 0.3607 |
Brugia malayi | SWIRM domain containing protein | 0.0118 | 0.107 | 0.1102 |
Echinococcus granulosus | serotonin transporter | 0.0058 | 0.0383 | 0.3818 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.0383 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0112 | 0.1002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0361 | 0.0361 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0057 | 0.0361 | 0.3607 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0112 | 0.1002 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0057 | 0.0361 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0057 | 0.0361 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0025 | 0 | 0.0002 |
Loa Loa (eye worm) | serotonin transporter b | 0.0058 | 0.0383 | 0.0383 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0361 | 0.0372 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0057 | 0.0361 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0057 | 0.0361 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0057 | 0.0361 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0058 | 0.0383 | 0.3818 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1002 | 0.1002 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0058 | 0.0383 | 0.0394 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/D50 (functional) | = 4.59 | Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. | ChEMBL. | 7069706 |
Log 1/LD10 (ADMET) | = 3.93 | Compound concentration in mole/kg/day lethal to 10% of mice | ChEMBL. | 7069706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.