Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | spleen tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus multilocularis | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K05855 spleen tyrosine kinase, putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus granulosus | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Echinococcus granulosus | cyclin B | 0.031 | 0.0203 | 0.0095 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 0.015 | 0.0041 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.031 | 0.0203 | 0.5 |
Schistosoma mansoni | cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Entamoeba histolytica | cyclin, putative | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Leishmania major | cyclin | 0.031 | 0.0203 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.031 | 0.0203 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0589 | 0.0529 | 0.0332 |
Trichomonas vaginalis | cyclin D, putative | 0.0229 | 0.0109 | 0.539 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0229 | 0.0109 | 0.539 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.031 | 0.0203 | 0.5 |
Schistosoma mansoni | cyclin B | 0.031 | 0.0203 | 0.0095 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.871 | 1 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0229 | 0.0109 | 0.539 |
Echinococcus multilocularis | cyclin B | 0.031 | 0.0203 | 0.0095 |
Plasmodium falciparum | cyclin | 0.0229 | 0.0109 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.0109 | 0.539 |
Trypanosoma cruzi | cyclin, putative | 0.031 | 0.0203 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0229 | 0.0109 | 0.539 |
Schistosoma mansoni | Hyaluronidase | 0.871 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0264 | 0.015 | 0.0041 |
Trypanosoma brucei | mitotic cyclin 6 | 0.031 | 0.0203 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0174 | 0.0045 | 0.5 |
Loa Loa (eye worm) | hyaluronidase | 0.871 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0264 | 0.015 | 0.0041 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0258 | 0.0143 | 0.0034 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.031 | 0.0203 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Onchocerca volvulus | 0.031 | 0.0203 | 0.5 | |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.031 | 0.0203 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0229 | 0.0109 | 0.539 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.871 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.37 | 0.4157 | 0.4036 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0589 | 0.0529 | 0.0332 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.871 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.937 uM | Inhibition of spleen tyrosine kinase (unknown origin) | ChEMBL. | 23917087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.