Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.004 | 0.0778 | 0.0778 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0039 | 0.0754 | 0.0754 |
Schistosoma mansoni | lipoxygenase | 0.002 | 0.0265 | 0.0265 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1316 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0039 | 0.0754 | 0.0754 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0039 | 0.0754 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0754 | 0.0754 |
Echinococcus multilocularis | expressed protein | 0.0039 | 0.0754 | 0.084 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.004 | 0.0778 | 0.0867 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1316 | 0.1467 |
Echinococcus granulosus | axis inhibition protein axin | 0.0039 | 0.0754 | 0.084 |
Schistosoma mansoni | axis inhibition protein axin | 0.0039 | 0.0754 | 0.0754 |
Echinococcus granulosus | RUN | 0.002 | 0.0265 | 0.0295 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0039 | 0.0754 | 0.084 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0039 | 0.0754 | 0.084 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0039 | 0.0754 | 0.0754 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0754 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0754 | 0.5 |
Onchocerca volvulus | 0.002 | 0.0265 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0754 | 0.0754 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0.0265 | 0.5 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0039 | 0.0754 | 0.084 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0039 | 0.0754 | 0.084 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0039 | 0.0754 | 0.084 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0265 | 0.0295 |
Schistosoma mansoni | lipoxygenase | 0.0057 | 0.123 | 0.123 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1316 | 0.1316 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.0754 | 0.0754 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0265 | 0.0265 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0925 | 0.0925 |
Brugia malayi | hypothetical protein | 0.002 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0925 | 0.0925 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1316 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0754 | 0.0754 |
Echinococcus multilocularis | RUN | 0.002 | 0.0265 | 0.0295 |
Brugia malayi | PXA domain containing protein | 0.0039 | 0.0754 | 0.0754 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0754 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0265 | 0.0295 |
Echinococcus granulosus | expressed protein | 0.0039 | 0.0754 | 0.084 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0754 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0265 | 0.0265 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.0754 | 0.0754 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0.0265 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.0265 | 0.0265 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.0754 | 0.0754 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0039 | 0.0754 | 0.0754 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.0754 | 0.0754 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0039 | 0.0754 | 0.084 |
Loa Loa (eye worm) | doublecortin family protein | 0.002 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | RGS-3 protein | 0.0039 | 0.0754 | 0.0754 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1316 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0754 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0754 | 0.0754 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.004 | 0.0778 | 0.0778 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0039 | 0.0754 | 0.084 |
Schistosoma mansoni | axis inhibition protein axin | 0.0039 | 0.0754 | 0.0754 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0925 | 0.103 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.004 | 0.0778 | 0.0867 |
Brugia malayi | hypothetical protein | 0.002 | 0.0265 | 0.0265 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0039 | 0.0754 | 0.0754 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1316 | 0.5 |
Echinococcus granulosus | axis inhibition protein axin | 0.0039 | 0.0754 | 0.084 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0039 | 0.0754 | 0.084 |
Onchocerca volvulus | 0.002 | 0.0265 | 1 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0925 | 0.0925 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0039 | 0.0754 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0754 | 0.0754 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0754 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0352 | 0.8975 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0265 | 0.0295 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0039 | 0.0754 | 0.0754 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0039 | 0.0754 | 0.0754 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0925 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0754 | 0.0754 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1316 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0754 | 0.5 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0039 | 0.0754 | 0.0754 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0039 | 0.0754 | 0.0754 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.0265 | 0.0265 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0754 | 1 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0265 | 0.0265 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0039 | 0.0754 | 0.0754 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0057 | 0.123 | 0.1371 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0039 | 0.0754 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0039 | 0.0754 | 0.0754 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0039 | 0.0754 | 0.084 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0039 | 0.0754 | 0.0754 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0754 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0352 | 0.8975 | 0.8975 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0352 | 0.8975 | 0.8975 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0352 | 0.8975 | 0.8975 |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0265 | 0.0265 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1316 | 0.1316 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0057 | 0.123 | 0.1371 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0265 | 0.0265 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1316 | 0.5 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0265 | 0.0295 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0265 | 0.0295 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0925 | 0.103 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0039 | 0.0754 | 0.084 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0039 | 0.0754 | 0.084 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0265 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0754 | 0.0754 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0754 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0925 | 0.0925 |
Schistosoma mansoni | serine/threonine protein kinase | 0.004 | 0.0778 | 0.0778 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0011 | 0.0025 | 0.0027 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1316 | 0.1467 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0925 | 0.103 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0352 | 0.8975 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0391 | 1 | 1 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0039 | 0.0754 | 0.084 |
Brugia malayi | PXA domain containing protein | 0.0039 | 0.0754 | 0.0754 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0391 | 1 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0039 | 0.0754 | 0.084 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.