Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0174 | 0.0174 |
Brugia malayi | hypothetical protein | 0.0168 | 0.0878 | 0.0878 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0008 | 0.0008 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0172 | 0.0902 | 0.1004 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0062 | 0.0239 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0008 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0109 | 0.0109 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0158 | 0.082 | 0.0913 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0158 | 0.082 | 0.0913 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0157 | 0.0157 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0157 | 0.0157 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0172 | 0.0902 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0451 | 0.0451 |
Echinococcus granulosus | axis inhibition protein axin | 0.0168 | 0.0878 | 0.0977 |
Brugia malayi | hypothetical protein | 0.0149 | 0.0763 | 0.0763 |
Echinococcus multilocularis | expressed protein | 0.0168 | 0.0878 | 0.0977 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0168 | 0.0878 | 0.0977 |
Onchocerca volvulus | 0.0023 | 0.0008 | 0.0101 | |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0172 | 0.0902 | 0.1004 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.0416 | 0.0462 |
Schistosoma mansoni | regulator of G protein signaling | 0.0168 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0878 | 0.0878 |
Onchocerca volvulus | 0.0149 | 0.0763 | 1 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.0701 | 0.078 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0252 | 0.0252 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0168 | 0.0878 | 0.0878 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0168 | 0.0878 | 0.0977 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0157 | 0.0175 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0118 | 0.0131 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0172 | 0.0902 | 0.0902 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.0451 | 0.0502 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0168 | 0.0878 | 0.0977 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0157 | 0.0175 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0109 | 0.0109 |
Schistosoma mansoni | axis inhibition protein axin | 0.0168 | 0.0878 | 0.0878 |
Entamoeba histolytica | hypothetical protein | 0.0168 | 0.0878 | 1 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0168 | 0.0878 | 0.0977 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0008 | 0.0008 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0799 | 0.4675 | 0.5201 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0252 | 1 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1516 | 0.8989 | 0.8989 |
Schistosoma mansoni | regulator of G protein signaling | 0.0168 | 0.0878 | 0.0878 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0252 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0172 | 0.0902 | 0.0902 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0157 | 0.0157 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0168 | 0.0878 | 0.0977 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0168 | 0.0878 | 0.0977 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0022 | 0 | 0.5 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | regulator of G protein signaling | 0.0168 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0008 | 0.0008 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1516 | 0.8989 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.0878 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0252 | 1 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0168 | 0.0878 | 0.0878 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0252 | 0.028 |
Echinococcus multilocularis | alkaline phosphatase | 0.0158 | 0.082 | 0.0913 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1516 | 0.8989 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | lipoxygenase | 0.0062 | 0.0239 | 0.0239 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0157 | 0.0175 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0168 | 0.0878 | 0.0878 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0008 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.0878 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.0878 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | alkaline phosphatase | 0.0158 | 0.082 | 0.082 |
Echinococcus granulosus | alkaline phosphatase | 0.0158 | 0.082 | 0.0913 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0252 | 0.0252 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0158 | 0.082 | 0.0913 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0109 | 0.0109 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0168 | 0.0878 | 0.0878 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0252 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0252 | 0.028 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0168 | 0.0878 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0158 | 0.082 | 0.0913 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0168 | 0.0878 | 0.0977 |
Brugia malayi | PXA domain containing protein | 0.0168 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0878 | 0.0878 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.0451 | 0.5093 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.0878 | 1 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0168 | 0.0878 | 0.0977 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0118 | 0.0118 |
Brugia malayi | PXA domain containing protein | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | alkaline phosphatase | 0.0158 | 0.082 | 0.082 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0252 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0168 | 0.0878 | 0.0977 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0118 | 0.0131 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0118 | 0.0131 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.0451 | 0.0502 |
Echinococcus granulosus | axis inhibition protein axin | 0.0168 | 0.0878 | 0.0977 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0168 | 0.0878 | 0.0977 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0168 | 0.0878 | 0.0878 |
Brugia malayi | hypothetical protein | 0.0168 | 0.0878 | 0.0878 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0062 | 0.0239 | 0.0266 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0168 | 0.0878 | 0.0878 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.0878 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0153 | 0.017 |
Loa Loa (eye worm) | RGS-3 protein | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | axis inhibition protein axin | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0118 | 0.0118 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0008 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0168 | 0.0878 | 1 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0157 | 0.0157 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.0416 | 0.0462 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0008 | 0.0008 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1516 | 0.8989 | 0.8989 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1516 | 0.8989 | 0.8989 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0008 | 0.0008 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0157 | 0.0157 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0109 | 0.0109 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0168 | 0.0878 | 0.0977 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0362 | 0.0362 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0168 | 0.0878 | 0.0977 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0878 | 0.0878 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0252 | 1 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0168 | 0.0878 | 0.0977 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.0878 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1684 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0763 | 0.0763 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0158 | 0.082 | 0.0913 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1684 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.0168 | 0.0878 | 0.0977 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0157 | 0.0175 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0168 | 0.0878 | 0.0977 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0158 | 0.082 | 0.0913 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.0701 | 0.078 |
Schistosoma mansoni | regulator of G protein signaling | 0.0168 | 0.0878 | 0.0878 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0168 | 0.0878 | 0.0977 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0878 | 0.0878 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.0451 | 0.0451 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0118 | 0.0118 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0168 | 0.0878 | 0.0878 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.046 | 0.046 |
Entamoeba histolytica | hypothetical protein | 0.0168 | 0.0878 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0118 | 0.0131 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 44 % | Neuroprotective activity against mouse HT22 cells assessed as inhibition of HCA-induced cell injury pretreated at 30 uM for 30 mins measured after 24 hrs by MTT assay | ChEMBL. | 23973819 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.