TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 307.686 | Formula: C14H10ClNO5
H donors: 0 H acceptors: 5 LogP: 2.12 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)[N+](=O)[O-])C(=O)C1C(=O)C[C@@H]2[C@H](C1=O)C2
InChi: 1S/C14H10ClNO5/c15-7-1-2-8(10(5-7)16(20)21)13(18)12-11(17)4-6-3-9(6)14(12)19/h1-2,5-6,9,12H,3-4H2/t6-,9-,12?/m1/s1
InChiKey: MKTDFJCGANZGFP-CNSBWROCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Aurora kinase	0.0174	0.1263	0.7643
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0174	0.1263	0.7643
Trichomonas vaginalis	cyclins, putative	0.0178	0.129	0.7809
Echinococcus multilocularis	regulator of G protein signaling 3	0.0039	0.0144	0.0479
Echinococcus granulosus	cyclin G2	0.0031	0.0071	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0178	0.129	0.129
Echinococcus multilocularis	cyclins	0.0127	0.0867	0.2894
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0174	0.1263	0.7643
Echinococcus granulosus	regulator of G protein signaling 7	0.0039	0.0144	0.0479
Trichomonas vaginalis	AGC family protein kinase	0.0174	0.1263	0.7643
Echinococcus multilocularis	cyclin dependent kinase 1	0.0221	0.1652	0.5514
Trypanosoma brucei	cdc2-related kinase 3	0.0221	0.1652	1
Echinococcus multilocularis	regulator of G protein signaling	0.0039	0.0144	0.0479
Schistosoma mansoni	Cyclin fold protein	0.0031	0.0071	0.0237
Schistosoma mansoni	cyclin B	0.0178	0.129	0.4306
Loa Loa (eye worm)	cyclin domain-containing protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0178	0.129	0.129
Echinococcus multilocularis	cyclin y	0.0031	0.0071	0.0237
Schistosoma mansoni	g1/s-specific cyclin C	0.0031	0.0071	0.0237
Trypanosoma brucei	mitotic cyclin	0.0031	0.0071	0.043
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0039	0.0144	0.0144
Trypanosoma cruzi	cdc2-related kinase 3	0.0221	0.1652	1
Echinococcus granulosus	cyclin y	0.0031	0.0071	0.0237
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0031	0.0071	0.043
Trichomonas vaginalis	cyclin B3, putative	0.0031	0.0071	0.043
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0127	0.0867	0.2894
Echinococcus multilocularis	cyclins	0.0127	0.0867	0.2894
Loa Loa (eye worm)	cyclin domain-containing protein	0.0031	0.0071	0.0071
Echinococcus granulosus	cyclin b3	0.0127	0.0867	0.2894
Echinococcus multilocularis	cyclin G2	0.0031	0.0071	0.0237
Schistosoma mansoni	serine/threonine protein kinase	0.0174	0.1263	0.4214
Trypanosoma cruzi	cyclin 9, putative	0.0031	0.0071	0.043
Echinococcus granulosus	cyclin B3 1	0.0127	0.0867	0.2894
Trypanosoma cruzi	cyclin 6, putative	0.0178	0.129	0.7809
Giardia lamblia	G2/mitotic-specific cyclin B	0.0178	0.129	0.7809
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0221	0.1652	0.1652
Trypanosoma cruzi	cdc2-related kinase 1	0.0221	0.1652	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0144
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0031	0.0071	0.043
Giardia lamblia	Hypothetical protein	0.0127	0.0867	0.5248
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0127	0.0867	0.0867
Trichomonas vaginalis	cyclin D, putative	0.0031	0.0071	0.043
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0144	0.0479
Giardia lamblia	Cyclin fold protein 1, putative	0.0031	0.0071	0.043
Echinococcus multilocularis	cyclins	0.0127	0.0867	0.2894
Trypanosoma brucei	cdc2-related kinase 1	0.0221	0.1652	1
Schistosoma mansoni	cyclin d	0.0031	0.0071	0.0237
Loa Loa (eye worm)	cyclin domain-containing protein	0.0031	0.0071	0.0071
Brugia malayi	Cyclin C	0.0031	0.0071	0.0071
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0174	0.1263	0.7643
Brugia malayi	regulator of G-protein signaling egl-10	0.0039	0.0144	0.0144
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0039	0.0144	0.0479
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0261	0.0261
Schistosoma mansoni	cyclin G	0.0031	0.0071	0.0237
Trypanosoma brucei	cyclin 9	0.0031	0.0071	0.043
Echinococcus granulosus	cyclins	0.0031	0.0071	0.0237
Schistosoma mansoni	axis inhibition protein axin	0.0039	0.0144	0.0479
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0044	0.0182	0.0182
Schistosoma mansoni	cyclins	0.0127	0.0867	0.2894
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0182	0.0609
Schistosoma mansoni	cyclin k	0.0031	0.0071	0.0237
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0039	0.0144	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0144
Echinococcus multilocularis	cyclin G2	0.0031	0.0071	0.0237
Schistosoma mansoni	serine/threonine protein kinase	0.0384	0.2996	1
Echinococcus granulosus	cyclin A3 4	0.0031	0.0071	0.0237
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0071	0.0071
Schistosoma mansoni	protein kinase	0.0174	0.1263	0.4214
Loa Loa (eye worm)	cyclin domain-containing protein	0.1229	1	1
Entamoeba histolytica	protein kinase, putative	0.0174	0.1263	0.7643
Plasmodium falciparum	cyclin 1	0.0031	0.0071	0.043
Entamoeba histolytica	protein kinase domain containing protein	0.0174	0.1263	0.7643
Trichomonas vaginalis	cyclins, putative	0.0178	0.129	0.7809
Entamoeba histolytica	hypothetical protein	0.0039	0.0144	0.0869
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0031	0.0071	0.0071
Giardia lamblia	Kinase, CMGC CDK	0.0221	0.1652	1
Echinococcus multilocularis	cyclins	0.0127	0.0867	0.2894
Trichomonas vaginalis	CMGC family protein kinase	0.0221	0.1652	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0044	0.0182	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0241	0.0241
Schistosoma mansoni	axis inhibition protein axin	0.0039	0.0144	0.0479
Toxoplasma gondii	hypothetical protein	0.0031	0.0071	0.043
Echinococcus multilocularis	G1:S specific cyclin D1	0.0031	0.0071	0.0237
Echinococcus multilocularis	cyclin k	0.0031	0.0071	0.0237
Brugia malayi	serine/threonine protein kinase 6	0.0174	0.1263	0.1263
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0071	0.043
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0144
Entamoeba histolytica	cyclin, putative	0.0127	0.0867	0.5248
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0039	0.0144	0.0479
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0174	0.1263	0.4214
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0071	0.043
Echinococcus granulosus	cyclins	0.0127	0.0867	0.2894
Echinococcus granulosus	cyclin	0.0031	0.0071	0.0237
Trichomonas vaginalis	cyclins, putative	0.0082	0.0494	0.2992
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0144	0.0869
Trichomonas vaginalis	cyclin A, putative	0.0178	0.129	0.7809
Entamoeba histolytica	cyclin C, putative	0.0031	0.0071	0.043
Echinococcus granulosus	cyclin dependent kinase 1	0.0221	0.1652	0.5514
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0174	0.1263	0.4214
Echinococcus granulosus	regulator of G protein signaling 3	0.0039	0.0144	0.0479
Toxoplasma gondii	cyclin 4, putative	0.0031	0.0071	0.043
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0039	0.0144	0.0144
Echinococcus granulosus	cyclin dependent kinase	0.0221	0.1652	0.5514
Leishmania major	protein kinase, putative	0.0174	0.1263	0.7643
Brugia malayi	Protein kinase domain containing protein	0.0221	0.1652	0.1652
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0031	0.0071	0.0237
Echinococcus multilocularis	cyclin dependent kinase 5	0.0221	0.1652	0.5514
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0031	0.0071	0.043
Trypanosoma cruzi	cdc2-related kinase 1	0.0221	0.1652	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0039	0.0144	0.0479
Echinococcus granulosus	cyclins	0.0127	0.0867	0.2894
Trichomonas vaginalis	AGC family protein kinase	0.0174	0.1263	0.7643
Echinococcus multilocularis	cyclin A3 4	0.0031	0.0071	0.0237
Trichomonas vaginalis	AGC family protein kinase	0.0174	0.1263	0.7643
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0237
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0178	0.129	0.129
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0144
Entamoeba histolytica	cyclin, putative	0.0178	0.129	0.7809
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Entamoeba histolytica	hypothetical protein	0.0042	0.0166	0.1006
Echinococcus multilocularis	cyclin t1	0.0031	0.0071	0.0237
Echinococcus multilocularis	cyclin B3 1	0.0127	0.0867	0.2894
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0144	0.0479
Plasmodium vivax	protein kinase Crk2	0.0221	0.1652	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0166	0.0555
Trypanosoma cruzi	cyclin, putative	0.0178	0.129	0.7809
Echinococcus multilocularis	cyclins	0.0127	0.0867	0.2894
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0031	0.0071	0.0237
Brugia malayi	A-kinase anchor protein 10, precursor	0.0039	0.0144	0.0144
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0071	0.0071
Plasmodium vivax	cyclin 4, putative	0.0031	0.0071	0.043
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0261	0.0261
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0344	0.2671	0.8913
Echinococcus multilocularis	cyclins	0.0127	0.0867	0.2894
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0221	0.1652	0.1652
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0144	0.0869
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0031	0.0071	0.043
Echinococcus multilocularis	axis inhibition protein axin	0.0039	0.0144	0.0479
Leishmania major	mitotic cyclin, putative	0.0031	0.0071	0.043
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0039	0.0144	0.0144
Trypanosoma cruzi	cyclin, putative	0.0178	0.129	0.7809
Leishmania major	cyclin 9, putative	0.0031	0.0071	0.043
Leishmania major	mitotic cyclin, putative	0.0031	0.0071	0.043
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0261	0.087
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0178	0.129	0.129
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0221	0.1652	0.5514
Trypanosoma cruzi	mitotic cyclin, putative	0.0031	0.0071	0.043
Trichomonas vaginalis	cyclin A, putative	0.0031	0.0071	0.043
Echinococcus multilocularis	cyclins	0.0127	0.0867	0.2894
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0344	0.2671	0.8913
Brugia malayi	PXA domain containing protein	0.0039	0.0144	0.0144
Trichomonas vaginalis	cyclin B, putative	0.0178	0.129	0.7809
Toxoplasma gondii	hypothetical protein	0.0096	0.0614	0.3715
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0166	0.0555
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0144	0.0479
Brugia malayi	serine/threonine-protein kinase 6	0.0174	0.1263	0.1263
Entamoeba histolytica	hypothetical protein	0.0042	0.0166	0.1006
Echinococcus multilocularis	cyclin dependent kinase	0.0221	0.1652	0.5514
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0071	0.043
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0384	0.2996	0.2996
Echinococcus granulosus	cyclins	0.0127	0.0867	0.2894
Trypanosoma brucei	aurora B kinase	0.0174	0.1263	0.7643
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0178	0.129	0.7809
Trichomonas vaginalis	CMGC family protein kinase	0.0221	0.1652	1
Echinococcus granulosus	Regulator of G protein signaling 20	0.0039	0.0144	0.0479
Brugia malayi	cyclin fold protein 1 variant b	0.0031	0.0071	0.0071
Brugia malayi	hypothetical protein	0.0039	0.0144	0.0144
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0261	0.087
Echinococcus multilocularis	cyclin	0.0031	0.0071	0.0237
Entamoeba histolytica	cyclin, domain containing protein	0.0031	0.0071	0.043
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0071	0.043
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0178	0.129	0.7809
Echinococcus multilocularis	regulator of G protein signaling 3	0.0039	0.0144	0.0479
Leishmania major	cyclin	0.0178	0.129	0.7809
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0174	0.1263	0.7643
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0031	0.0071	0.043
Loa Loa (eye worm)	AUR protein kinase	0.0174	0.1263	0.1263
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0144	0.0869
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0174	0.1263	0.7643
Echinococcus granulosus	axis inhibition protein axin	0.0039	0.0144	0.0479
Schistosoma mansoni	cyclin B3	0.0127	0.0867	0.2894
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0071	0.043
Giardia lamblia	Kinase, CMGC CDK	0.0221	0.1652	1
Giardia lamblia	Cyclin A	0.0127	0.0867	0.5248
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0144	0.0479
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0071	0.043
Schistosoma mansoni	cyclin G2	0.0031	0.0071	0.0237
Trypanosoma cruzi	mitotic cyclin, putative	0.0031	0.0071	0.043
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0221	0.1652	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0031	0.0071	0.0071
Trypanosoma cruzi	cdc2-related kinase 3	0.0221	0.1652	1
Trypanosoma cruzi	aurora B kinase, putative	0.0174	0.1263	0.7643
Giardia lamblia	Cyclin B-like protein	0.0031	0.0071	0.043
Loa Loa (eye worm)	AUR protein kinase	0.0174	0.1263	0.1263
Loa Loa (eye worm)	RGS-3 protein	0.0039	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0031	0.0071	0.0237
Trichomonas vaginalis	cyclin B, putative	0.0178	0.129	0.7809
Trichomonas vaginalis	cyclins, putative	0.0127	0.0867	0.5248
Trichomonas vaginalis	cyclins, putative	0.0031	0.0071	0.043
Loa Loa (eye worm)	cyclin domain-containing protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	regulator of G protein signaling 7	0.0039	0.0144	0.0479
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0221	0.1652	1
Echinococcus granulosus	cyclin B	0.0178	0.129	0.4306
Entamoeba histolytica	hypothetical protein	0.0039	0.0144	0.0869
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0039	0.0144	0.0479
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	regulator of G protein signaling 7	0.0039	0.0144	0.0479
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0	0.5
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0384	0.2996	1
Entamoeba histolytica	cyclin, domain containing protein	0.0031	0.0071	0.043
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0384	0.2996	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0261	0.087
Echinococcus granulosus	cyclins	0.0127	0.0867	0.2894
Echinococcus granulosus	cyclin dependent kinase 5	0.0221	0.1652	0.5514
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0	0.5
Plasmodium falciparum	protein kinase 5	0.0221	0.1652	1
Trichomonas vaginalis	cyclin B, putative	0.0178	0.129	0.7809
Echinococcus granulosus	aurora kinase A	0.0174	0.1263	0.4214
Schistosoma mansoni	serine/threonine protein kinase	0.0221	0.1652	0.5514
Echinococcus granulosus	cyclin t1	0.0031	0.0071	0.0237
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	cyclin b3	0.0127	0.0867	0.2894
Brugia malayi	PXA domain containing protein	0.0039	0.0144	0.0144
Entamoeba histolytica	cyclin family protein	0.0127	0.0867	0.5248
Echinococcus granulosus	expressed protein	0.0039	0.0144	0.0479
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0221	0.1652	0.1652
Schistosoma mansoni	serine/threonine protein kinase	0.0221	0.1652	0.5514
Echinococcus granulosus	regulator of G protein signaling 3	0.0039	0.0144	0.0479
Echinococcus multilocularis	cyclin y	0.0031	0.0071	0.0237
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0261	0.087
Echinococcus granulosus	cyclin G2	0.0031	0.0071	0.0237
Schistosoma mansoni	z-protein (S1r protein)	0.0039	0.0144	0.0479
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0071	0.0071
Brugia malayi	serine/threonine kinase 12	0.0174	0.1263	0.1263
Echinococcus granulosus	G1:S specific cyclin D1	0.0031	0.0071	0.0237
Trichomonas vaginalis	conserved hypothetical protein	0.0127	0.0867	0.5248
Entamoeba histolytica	hypothetical protein	0.0031	0.0071	0.043
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0221	0.1652	1
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0031	0.0071	0.043
Echinococcus multilocularis	axis inhibition protein axin	0.0039	0.0144	0.0479
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0144	0.0479
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0144	0.0869
Loa Loa (eye worm)	PXA domain-containing protein	0.0039	0.0144	0.0144
Brugia malayi	hypothetical protein	0.0039	0.0144	0.0144
Echinococcus multilocularis	cyclin B	0.0178	0.129	0.4306
Echinococcus granulosus	Cyclin L1	0.0031	0.0071	0.0237
Echinococcus multilocularis	aurora kinase A	0.0174	0.1263	0.4214
Trichomonas vaginalis	cyclin B, putative	0.0178	0.129	0.7809
Entamoeba histolytica	cyclin family protein	0.0127	0.0867	0.5248
Loa Loa (eye worm)	CYL-1 protein	0.0031	0.0071	0.0071
Toxoplasma gondii	aurora kinase	0.0174	0.1263	0.7643
Entamoeba histolytica	hypothetical protein	0.0042	0.0166	0.1006
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0144	0.0869
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0	0.5
Loa Loa (eye worm)	cyclin domain-containing protein	0.0127	0.0867	0.0867
Entamoeba histolytica	protein kinase , putative	0.0174	0.1263	0.7643
Loa Loa (eye worm)	cyclin C	0.0031	0.0071	0.0071
Plasmodium falciparum	cyclin	0.0127	0.0867	0.5248
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0261	0.087
Brugia malayi	cell division control protein 2 homolog	0.0221	0.1652	0.1652
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0144	0.0869
Trichomonas vaginalis	cyclin B, putative	0.0127	0.0867	0.5248
Schistosoma mansoni	cyclin l	0.0031	0.0071	0.0237
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0166	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0144
Brugia malayi	regulator of G-protein signaling rgs-7	0.0039	0.0144	0.0144
Entamoeba histolytica	hypothetical protein	0.0039	0.0144	0.0869
Giardia lamblia	Hypothetical protein	0.0031	0.0071	0.043
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0144
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0261	0.087
Schistosoma mansoni	hypothetical protein	0.0042	0.0166	0.0555
Onchocerca volvulus		0.0178	0.129	1
Echinococcus multilocularis	expressed protein	0.0039	0.0144	0.0479
Loa Loa (eye worm)	AUR protein kinase	0.0174	0.1263	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1613	0.1613
Trichomonas vaginalis	cyclin D, putative	0.0127	0.0867	0.5248
Trichomonas vaginalis	cyclins, putative	0.0178	0.129	0.7809
Trichomonas vaginalis	CMGC family protein kinase	0.0221	0.1652	1
Trichomonas vaginalis	AGC family protein kinase	0.0174	0.1263	0.7643
Entamoeba histolytica	cell division protein kinase 2, putative	0.0221	0.1652	1
Trypanosoma brucei	cyclin 3	0.0031	0.0071	0.043
Trichomonas vaginalis	cyclin B3, putative	0.0127	0.0867	0.5248
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0031	0.0071	0.0237
Entamoeba histolytica	hypothetical protein	0.0042	0.0166	0.1006
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Entamoeba histolytica	cell division protein kinase 2, putative	0.0221	0.1652	1
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0031	0.0071	0.043
Schistosoma mansoni	serine/threonine protein kinase	0.0384	0.2996	1
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0127	0.0867	0.2894
Brugia malayi	hypothetical protein	0.0042	0.0166	0.0166
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0031	0.0071	0.0237
Echinococcus multilocularis	cyclin dependent kinase 1	0.0221	0.1652	0.5514
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0	0.5
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0071	0.043
Plasmodium vivax	cyclin homologue, putative	0.0031	0.0071	0.043
Giardia lamblia	Hypothetical protein	0.0031	0.0071	0.043
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0039	0.0144	0.0479
Echinococcus multilocularis	Cyclin L1	0.0031	0.0071	0.0237
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0039	0.0144	0.0479
Trypanosoma brucei	mitotic cyclin 6	0.0178	0.129	0.7809
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0261	0.087
Trichomonas vaginalis	cyclin D, putative	0.0127	0.0867	0.5248
Entamoeba histolytica	protein kinase, putative	0.0174	0.1263	0.7643
Echinococcus granulosus	axis inhibition protein axin	0.0039	0.0144	0.0479
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0071	0.043
Echinococcus granulosus	cyclins	0.0127	0.0867	0.2894
Echinococcus granulosus	cyclin y	0.0031	0.0071	0.0237
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0039	0.0144	0.0479
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0071	0.0071
Echinococcus granulosus	cyclin k	0.0031	0.0071	0.0237
Trichomonas vaginalis	cyclins, putative	0.0178	0.129	0.7809
Trichomonas vaginalis	cyclins, putative	0.0031	0.0071	0.043
Trichomonas vaginalis	cyclin B3, putative	0.0031	0.0071	0.043

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2271112

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1789569