Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.049 | 0.4122 | 0.4122 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.113 | 0.9827 | 0.9827 |
Loa Loa (eye worm) | hypothetical protein | 0.113 | 0.9827 | 0.9826 |
Mycobacterium leprae | conserved hypothetical protein | 0.0044 | 0.0137 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.113 | 0.9827 | 0.9827 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1149 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0137 | 0.0137 |
Giardia lamblia | Hypothetical protein | 0.0678 | 0.5798 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0678 | 0.5798 | 1 |
Brugia malayi | beta-lactamase | 0.0044 | 0.0137 | 0.1349 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.049 | 0.4122 | 0.4087 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0044 | 0.0137 | 0.0078 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 0.0242 | 0.0184 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0242 | 0.0184 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0279 | 0.2239 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Echinococcus multilocularis | snurportin 1 | 0.0374 | 0.3082 | 0.3041 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0242 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Schistosoma mansoni | hypothetical protein | 0.0374 | 0.3082 | 0.3041 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0044 | 0.0137 | 0.1349 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0678 | 0.5798 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0137 | 0.0137 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0044 | 0.0137 | 0.0078 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 0.0242 | 0.0184 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 0.0242 | 0.0184 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0044 | 0.0137 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 0.0242 | 0.0184 |
Onchocerca volvulus | 0.1149 | 1 | 1 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0044 | 0.0137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.5625 | 0.5599 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.113 | 0.9827 | 0.9826 |
Mycobacterium leprae | Probable lipase LipE | 0.0044 | 0.0137 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1149 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0044 | 0.0137 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0242 | 0.0184 |
Loa Loa (eye worm) | beta-lactamase | 0.0044 | 0.0137 | 0.0078 |
Brugia malayi | beta-lactamase family protein | 0.0044 | 0.0137 | 0.1349 |
Giardia lamblia | Hypothetical protein | 0.0678 | 0.5798 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1149 | 1 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0035 | 0.0059 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0044 | 0.0137 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0044 | 0.0137 | 0.0078 |
Plasmodium vivax | hypothetical protein, conserved | 0.0044 | 0.0137 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0374 | 0.3082 | 0.3041 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0044 | 0.0137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1149 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.113 | 0.9827 | 0.9827 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0044 | 0.0137 | 0.0078 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0044 | 0.0137 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0056 | 0.0242 | 0.0184 |
Leishmania major | hypothetical protein, conserved | 0.0044 | 0.0137 | 0.0137 |
Mycobacterium ulcerans | hypothetical protein | 0.0678 | 0.5798 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.01 | 0.0635 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.049 | 0.4122 | 0.4122 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0056 | 0.0242 | 0.318 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0044 | 0.0137 | 0.0078 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1149 | 1 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0374 | 0.3082 | 0.3041 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.049 | 0.4122 | 0.4122 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0044 | 0.0137 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0044 | 0.0137 | 0.1349 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0044 | 0.0137 | 0.0078 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 5.4 mm | Antimicrobial activity against Escherichia coli ATCC 11230 at 25 ug/disk measured after overnight incubation by disk diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.