Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0044 | 0.0137 | 0.1349 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1149 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0242 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.5625 | 0.5599 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0044 | 0.0137 | 0.0078 |
Trichomonas vaginalis | esterase, putative | 0.0044 | 0.0137 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0044 | 0.0137 | 0.0078 |
Leishmania major | hypothetical protein, conserved | 0.0044 | 0.0137 | 0.0137 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 0.0242 | 0.0184 |
Giardia lamblia | Hypothetical protein | 0.0678 | 0.5798 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0044 | 0.0137 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0044 | 0.0137 | 0.0078 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0056 | 0.0242 | 0.0184 |
Giardia lamblia | Hypothetical protein | 0.0678 | 0.5798 | 0.5 |
Brugia malayi | RNA, U transporter 1 | 0.01 | 0.0635 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0374 | 0.3082 | 0.3041 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.049 | 0.4122 | 0.4122 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0044 | 0.0137 | 0.1349 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.113 | 0.9827 | 0.9827 |
Plasmodium vivax | hypothetical protein, conserved | 0.0044 | 0.0137 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.113 | 0.9827 | 0.9826 |
Echinococcus granulosus | snurportin 1 | 0.0374 | 0.3082 | 0.3041 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0279 | 0.2239 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.113 | 0.9827 | 0.9827 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.049 | 0.4122 | 0.4122 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0242 | 0.0184 |
Brugia malayi | beta-lactamase family protein | 0.0044 | 0.0137 | 0.1349 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.049 | 0.4122 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0044 | 0.0137 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0044 | 0.0137 | 0.0078 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0137 | 0.0137 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 0.0242 | 0.0184 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1149 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0044 | 0.0137 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1149 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0678 | 0.5798 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 0.0242 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.113 | 0.9827 | 0.9826 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.049 | 0.4122 | 0.4122 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.113 | 0.9827 | 0.9827 |
Mycobacterium leprae | Probable lipase LipE | 0.0044 | 0.0137 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 0.0242 | 0.0184 |
Plasmodium falciparum | importin beta, putative | 0.0035 | 0.0059 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1149 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0044 | 0.0137 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0044 | 0.0137 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0044 | 0.0137 | 0.0078 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0056 | 0.0242 | 0.318 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0137 | 0.0078 |
Schistosoma mansoni | hypothetical protein | 0.0374 | 0.3082 | 0.3041 |
Brugia malayi | beta-lactamase | 0.0044 | 0.0137 | 0.1349 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0242 | 0.0184 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0678 | 0.5798 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0044 | 0.0137 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0044 | 0.0137 | 0.0078 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0137 | 0.0137 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0678 | 0.5798 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1149 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0044 | 0.0137 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0374 | 0.3082 | 0.3041 |
Onchocerca volvulus | 0.1149 | 1 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0044 | 0.0137 | 0.0078 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 5.4 mm | Antimicrobial activity against Escherichia coli ATCC 11230 at 25 ug/disk measured after overnight incubation by disk diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.