TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 266.291 | Formula: C17H14O3
H donors: 1 H acceptors: 2 LogP: 3.55 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cccc(c1)c1cc(=O)c2c(o1)c(C)cc(c2)C
InChi: 1S/C17H14O3/c1-10-6-11(2)17-14(7-10)15(19)9-16(20-17)12-4-3-5-13(18)8-12/h3-9,18H,1-2H3
InChiKey: RJIQVVFWVGXZDS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	casein kinase 2, beta polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium yoelii	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma congolense	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Babesia bovis	protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Loa Loa (eye worm)	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania major	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Neospora caninum	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium vivax	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania mexicana	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma mansoni	casein kinase II beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium hominis	protein kinase Ck2-beta	Get druggable targets OG5_126846	All targets in OG5_126846
Entamoeba histolytica	casein kinase II regulatory subunit family protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus granulosus	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania infantum	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Neospora caninum	YOR039Wp-like protein, related	Get druggable targets OG5_126846	All targets in OG5_126846
Brugia malayi	Csnk2b protein	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma cruzi	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium parvum	putative protein kinase CK2 regulatory subunit CK2B1	Get druggable targets OG5_126846	All targets in OG5_126846
Theileria parva	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Giardia lamblia	Casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei gambiense	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	casein kinase ii regulatory subunit protein	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium falciparum	casein kinase II beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania donovani	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Cryptosporidium parvum	putative casein kinase II regulatory subunit; besthit Pf 23508244	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Toxoplasma gondii	ck2 beta subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Leishmania braziliensis	protein kinase ck2 regulatory subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Onchocerca volvulus	Casein kinase II subunit beta homolog	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Babesia bovis	casein kinase II beta 4 subunit, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Echinococcus multilocularis	casein kinase ii subunit beta	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium berghei	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium knowlesi	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Schistosoma japonicum	ko:K03115 casein kinase 2, beta polypeptide, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Trypanosoma brucei	Casein kinase II subunit beta, putative	Get druggable targets OG5_126846	All targets in OG5_126846
Candida albicans	Casein kinase II, regulatory (beta-prime) subunit	Get druggable targets OG5_126846	All targets in OG5_126846
Plasmodium yoelii	casein kinase ii beta chain	Get druggable targets OG5_126846	All targets in OG5_126846
Trichomonas vaginalis	casein kinase II beta chain, putative	Get druggable targets OG5_126846	All targets in OG5_126846

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	casein kinase II beta chain	0.0044	0.0798	0.0798
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0044	0.0798	0.0798
Plasmodium falciparum	heat shock protein 90	0.0097	1	1
Trypanosoma brucei	heat shock protein 90, putative	0.0097	1	1
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0044	0.0798	1
Plasmodium vivax	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0044	0.0798	0.0798
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0044	0.0798	0.0798
Trypanosoma brucei	heat shock protein, putative	0.0097	1	1
Toxoplasma gondii	heat shock protein HSP90	0.0097	1	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0057	0.3058	0.3058
Trypanosoma brucei	heat shock protein, putative	0.0097	1	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Schistosoma mansoni	endoplasmin	0.0097	1	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0077	0.655	0.5
Echinococcus granulosus	heat shock protein 90	0.0077	0.655	0.655
Trypanosoma brucei	heat shock protein, putative	0.0097	1	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Trypanosoma brucei	heat shock protein, putative	0.0097	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Echinococcus multilocularis	heat shock protein 90	0.0097	1	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0097	1	1
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0798	0.0798
Leishmania major	heat shock protein 83-1	0.0097	1	1
Trypanosoma cruzi	Heat shock protein 83, putative	0.0097	1	1
Loa Loa (eye worm)	endoplasmin	0.0097	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Plasmodium vivax	endoplasmin, putative	0.0097	1	1
Echinococcus multilocularis	casein kinase ii subunit beta	0.0044	0.0798	0.0798
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0798	0.0798
Leishmania major	heat shock protein 83-1	0.0097	1	1
Mycobacterium ulcerans	heat shock protein 90	0.0077	0.655	0.5
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Trypanosoma cruzi	heat shock protein 85, putative	0.0097	1	1
Echinococcus granulosus	endoplasmin	0.0077	0.655	0.655
Trypanosoma cruzi	heat shock protein 85, putative	0.0077	0.655	0.655
Plasmodium vivax	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Trypanosoma brucei	Heat shock protein 83, putative	0.0097	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0077	0.655	0.655
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Schistosoma mansoni	heat shock protein	0.0097	1	1
Trypanosoma brucei	heat shock protein, putative	0.0097	1	1
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0044	0.0798	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0044	0.0798	0.0798
Leishmania major	heat shock protein 83-1	0.0097	1	1
Plasmodium vivax	heat shock protein 86, putative	0.0097	1	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Trypanosoma brucei	heat shock protein, putative	0.0097	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Leishmania major	heat shock protein 83-1	0.0097	1	1
Plasmodium falciparum	endoplasmin, putative	0.0059	0.345	0.345
Toxoplasma gondii	heat shock protein 90, putative	0.0097	1	1
Loa Loa (eye worm)	heat shock protein 90	0.0097	1	1
Trypanosoma brucei	heat shock protein 90, putative	0.0097	1	1
Entamoeba histolytica	heat shock protein 90, putative	0.0097	1	1
Echinococcus granulosus	heat shock protein 90	0.0097	1	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0077	0.655	0.625
Trypanosoma cruzi	heat shock protein 90, putative	0.0077	0.655	0.655
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Schistosoma mansoni	heat shock protein	0.0097	1	1
Trichomonas vaginalis	endoplasmin, putative	0.0059	0.345	0.345
Leishmania major	heat shock protein 83-1	0.0097	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0077	0.655	0.655
Trypanosoma brucei	heat shock protein, putative	0.0097	1	1
Schistosoma mansoni	casein kinase II beta subunit	0.0044	0.0798	0.0798
Echinococcus granulosus	casein kinase ii subunit beta	0.0044	0.0798	0.0798
Trichomonas vaginalis	heat shock protein, putative	0.0097	1	1
Echinococcus granulosus	heat shock protein	0.0097	1	1
Brugia malayi	Csnk2b protein	0.0044	0.0798	0.0798
Trichomonas vaginalis	heat shock protein, putative	0.0077	0.655	0.655
Loa Loa (eye worm)	Csnk2b protein	0.0044	0.0798	0.0798
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Leishmania major	heat shock protein 83-1	0.0097	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Trichomonas vaginalis	heat shock protein, putative	0.0059	0.345	0.345
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0044	0.0798	0.0798
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0097	1	1
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0077	0.655	0.655
Trypanosoma cruzi	heat shock protein 85, putative	0.0097	1	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Echinococcus multilocularis	endoplasmin	0.0077	0.655	0.655
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0077	0.655	0.655
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Giardia lamblia	Grp94/Hsp90	0.0077	0.655	0.625
Toxoplasma gondii	ck2 beta subunit	0.0044	0.0798	0.0798
Treponema pallidum	heat shock protein 90	0.0077	0.655	0.5
Schistosoma mansoni	endoplasmin	0.0097	1	1
Echinococcus multilocularis	heat shock protein	0.0097	1	1
Entamoeba histolytica	heat shock protein 90, putative	0.0097	1	1
Echinococcus multilocularis	heat shock protein 90	0.0077	0.655	0.655
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0044	0.0798	0.0798
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Plasmodium falciparum	casein kinase II beta chain	0.0044	0.0798	0.0798
Leishmania major	heat shock protein 83-1	0.0097	1	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0097	1	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0044	0.0798	0.0798
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0077	0.655	0.5
Leishmania major	heat shock protein 83-1	0.0097	1	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Trypanosoma brucei	heat shock protein, putative	0.0097	1	1
Brugia malayi	heat shock protein 90	0.0097	1	1
Leishmania major	heat shock protein 83-1	0.0097	1	1
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0077	0.655	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.2 uM	Inhibition of recombinant human CK2 using RRRDDDSDDD as substrate after 20 mins by beta counting analysis in presence of [gamma-labeled 32P]ATP	ChEMBL.	24011954

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2442410

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1790715