Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.2116 | 0.984 | 1 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.2116 | 0.984 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.2116 | 0.984 | 1 |
Brugia malayi | hypothetical protein | 0.025 | 0.1021 | 0.1038 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.0093 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0093 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.025 | 0.1021 | 0.1038 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.0093 | 1 |
Schistosoma mansoni | protein kinase | 0.0035 | 0.0002 | 0.0002 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.0093 | 0.0094 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0093 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0035 | 0.0002 | 0.0002 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.0093 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.0093 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0035 | 0.0002 | 0.0002 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0035 | 0.0002 | 0.0002 |
Plasmodium falciparum | protein kinase, putative | 0.0035 | 0.0002 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.2116 | 0.984 | 1 |
Echinococcus multilocularis | activin receptor type | 0.0035 | 0.0002 | 0.0002 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.0093 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.0093 | 0.0094 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.0093 | 1 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0035 | 0.0002 | 0.0248 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0079 | 0.0079 |
Plasmodium vivax | protein kinase, putative | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.0093 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.2116 | 0.9838 | 0.9998 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Echinococcus granulosus | activin receptor type | 0.0035 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.2116 | 0.9838 | 0.9998 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.0093 | 0.0094 |
Schistosoma mansoni | protein kinase | 0.0035 | 0.0002 | 0.0002 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.0093 | 0.0094 |
Leishmania major | protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.0093 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0093 | 1 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.025 | 0.1021 | 0.1038 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.0093 | 1 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0034 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.0093 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.1021 | 0.1038 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.0093 | 1 |
Schistosoma mansoni | protein kinase | 0.0035 | 0.0002 | 0.0002 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0093 | 1 |
Onchocerca volvulus | 0.0051 | 0.0079 | 1 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0035 | 0.0002 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0079 | 0.0081 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.0093 | 0.0094 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0079 | 0.0079 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 23.2 % | Cytotoxicity against Homo sapiens (human) MDA-MB-468 cells assessed as growth inhibition at 10 uM after 48 hr by coulter counter analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.