Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.025 | 0.1021 | 0.1038 |
Brugia malayi | Protein kinase domain containing protein | 0.2116 | 0.984 | 1 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.2116 | 0.984 | 1 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.2116 | 0.984 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.0093 | 0.0094 |
Schistosoma mansoni | protein kinase | 0.0035 | 0.0002 | 0.0002 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.025 | 0.1021 | 0.1038 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.0093 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0093 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.0093 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.2116 | 0.984 | 1 |
Plasmodium falciparum | protein kinase, putative | 0.0035 | 0.0002 | 1 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0035 | 0.0002 | 0.0002 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.0093 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.0093 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0035 | 0.0002 | 0.0002 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0035 | 0.0002 | 0.0002 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0093 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.0093 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.2116 | 0.9838 | 0.9998 |
Echinococcus granulosus | activin receptor type | 0.0035 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.2116 | 0.9838 | 0.9998 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Plasmodium vivax | protein kinase, putative | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0079 | 0.0079 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.0093 | 0.0094 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.0093 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.0093 | 0.0094 |
Echinococcus multilocularis | activin receptor type | 0.0035 | 0.0002 | 0.0002 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0035 | 0.0002 | 0.0248 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.0093 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.0093 | 1 |
Leishmania major | protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.0093 | 0.0094 |
Schistosoma mansoni | protein kinase | 0.0035 | 0.0002 | 0.0002 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.025 | 0.1021 | 0.1038 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.0093 | 1 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0035 | 0.0002 | 0.0248 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0093 | 1 |
Onchocerca volvulus | 0.0051 | 0.0079 | 1 | |
Schistosoma mansoni | protein kinase | 0.0035 | 0.0002 | 0.0002 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0093 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.0093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.1021 | 0.1038 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0093 | 0.0093 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.0093 | 1 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.0093 | 0.0094 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0035 | 0.0002 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0079 | 0.0081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 21.4 % | Cytotoxicity against Homo sapiens (human) MDA-MB-468 cells assessed as growth inhibition at 10 uM after 48 hr by coulter counter analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.