TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.554 | Formula: C23H33N7O2
H donors: 4 H acceptors: 4 LogP: 3.84 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1ccc(cc1)Nc1nc(ncc1C(=O)N)NN1CCCCC1)NCC(C)(C)C
InChi: 1S/C23H33N7O2/c1-23(2,3)15-26-19(31)13-16-7-9-17(10-8-16)27-21-18(20(24)32)14-25-22(28-21)29-30-11-5-4-6-12-30/h7-10,14H,4-6,11-13,15H2,1-3H3,(H2,24,32)(H,26,31)(H2,25,27,28,29)
InChiKey: BKSUJJAVIJPEDS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4B, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0106	0.4968	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0196	1	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0047	0.1694	0.1694
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0196	1	1
Echinococcus multilocularis	nervana 2	0.0046	0.1648	0.1648
Echinococcus granulosus	protein kinase C gamma type	0.0025	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0025	0.0423	0.0479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0112	0.5294	0.5294
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0106	0.4968	0.8171
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0028	0.0592	0.0627
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0277	0.0277
Brugia malayi	protein kinase C II.	0.0025	0.0423	0.0695
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0073	0.313	0.3543
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0025	0.0423	0.0423
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0038	0.1167	0.2348
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0106	0.4968	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0074	0.3211	0.3211
Echinococcus granulosus	protein kinase c epsilon type	0.0025	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0025	0.0423	0.0423
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0423	0.0423
Schistosoma mansoni	serine/threonine protein kinase	0.0126	0.6081	0.6081
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0423	0.0423
Loa Loa (eye worm)	phosphatidylinositol 3	0.0175	0.8833	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.5294	0.5294
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0025	0.0423	0.0479
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0025	0.0423	0.0423
Echinococcus granulosus	Glutaredoxin protein 5	0.0046	0.1648	0.1648
Echinococcus granulosus	Protein kinase C brain isozyme	0.0025	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0277	0.0557
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0277	0.0557
Loa Loa (eye worm)	hypothetical protein	0.007	0.2956	0.3346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0025	0.0423	0.0479
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0038	0.1167	0.2348
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.313	0.6299
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0074	0.3211	0.528
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0277	0.3067
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0277	0.0277
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.4534	0.4534
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0277	0.3067
Echinococcus granulosus	nervana 2	0.0046	0.1648	0.1648
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0046	0.1648	0.1648
Brugia malayi	Protein kinase domain containing protein	0.0025	0.0423	0.0695
Toxoplasma gondii	AGC kinase	0.0071	0.3018	0.5702
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0423	0.0479
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0025	0.0423	0.0479
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.009	0.4084	0.6717
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0903	0.1817
Entamoeba histolytica	protein kinase 2, putative	0.0047	0.1694	0.341
Echinococcus granulosus	serine/threonine protein kinase	0.0049	0.1806	0.1806
Echinococcus multilocularis	serine threonine protein kinase	0.0025	0.0423	0.0423
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0099	0.4596	0.9251
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.4534	0.4534
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0038	0.1167	0.2348
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0074	0.3211	0.6462
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.313	0.6299
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0074	0.3211	0.3211
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0277	0.0313
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0277	0.0885
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1066	0.1206
Entamoeba histolytica	protein kinase, putative	0.0073	0.313	0.6299
Schistosoma mansoni	serine/threonine-protein kinase	0.0049	0.1806	0.1806
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0038	0.1167	0.3728
Echinococcus multilocularis	rac serine:threonine kinase	0.0049	0.1806	0.1806
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0025	0.0423	0.0423
Loa Loa (eye worm)	phosphatidylinositol 3	0.0033	0.0903	0.1022
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0047	0.1694	0.1694
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0038	0.1167	0.2348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0277	0.0885
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0025	0.0423	0.0423
Entamoeba histolytica	protein kinase, putative	0.0073	0.313	0.6299
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.5294	0.5294
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0025	0.0423	0.0479
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0071	0.3018	0.3417
Brugia malayi	Protein kinase domain containing protein	0.0025	0.0423	0.0695
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0074	0.3179	0.6399
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0049	0.1789	0.3601
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.4534	0.5133
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0534	0.1075
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0049	0.1806	0.3635
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.313	0.6299
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0085	0.3802	0.7652
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0038	0.1167	0.2348
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0112	0.5294	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0113	0.5383	0.8852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0443	0.0891
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.2956	0.4861
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0423	0.0423
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0053	0.2013	0.346
Schistosoma mansoni	serine/threonine kinase	0.0025	0.0423	0.0423
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0106	0.4968	1
Entamoeba histolytica	hypothetical protein	0.0085	0.3802	0.7652
Echinococcus multilocularis	protein kinase c epsilon type	0.0025	0.0423	0.0423
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0113	0.5383	0.5383
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0277	0.0455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0033	0.0903	0.2885
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0277	0.3067
Brugia malayi	p70 ribosomal S6 kinase beta	0.0071	0.3018	0.4964
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0277	0.0277
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0126	0.6081	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0033	0.0903	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0113	0.5383	0.6094
Entamoeba histolytica	protein kinase, putative	0.0025	0.0423	0.0851
Brugia malayi	Protein kinase domain containing protein	0.0073	0.313	0.5147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0277	0.0557
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0047	0.1694	1
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0047	0.1694	1
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.313	0.6299
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.5294	0.5294
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0073	0.313	1
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Echinococcus granulosus	NDR protein kinase	0.0025	0.0423	0.0423
Schistosoma mansoni	serine/threonine-protein kinase	0.0049	0.1806	0.1806
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0423	0.0851
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0423	0.0851
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0049	0.1806	0.3635
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0126	0.6081	0.6884
Giardia lamblia	Kinase, AGC PKA	0.0047	0.1694	0.2825
Loa Loa (eye worm)	phosphatidylinositol 3	0.0031	0.0795	0.09
Entamoeba histolytica	protein kinase, putative	0.0071	0.3018	0.6075
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0038	0.1167	0.2348
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.4534	0.7457
Echinococcus granulosus	protein kinase c iota type	0.0025	0.0423	0.0423
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0277	0.0557
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0046	0.1648	0.1648
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0106	0.4968	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0277	0.0523
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0038	0.1167	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0112	0.5294	0.5993
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0025	0.0423	0.0423
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0277	0.0885
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0024	0.0377	0.0759
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.313	0.6299
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0047	0.1694	0.341
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0025	0.0423	0.0423
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0025	0.0443	0.0891
Echinococcus granulosus	serine threonine protein kinase nrc	0.0047	0.1694	0.1694
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0423	0.0423
Echinococcus multilocularis	protein kinase c iota type	0.0025	0.0423	0.0423
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.5294	0.5294
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Trypanosoma cruzi	Protein kinase B	0.0049	0.1806	0.3635
Brugia malayi	Hr1 repeat family protein	0.0025	0.0423	0.0695
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Echinococcus granulosus	serine:threonine protein kinase N2	0.0025	0.0423	0.0423
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0106	0.4968	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0277	0.3067
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0112	0.5294	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.007	0.2956	0.2956
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0025	0.0423	0.0479
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0074	0.3211	0.6462
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0277	0.0885
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0423	0.0851
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.313	0.6299
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0113	0.5383	0.5383
Echinococcus multilocularis	Glutaredoxin protein 5	0.0046	0.1648	0.1648
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0025	0.0423	0.0423
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0106	0.4968	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0025	0.0423	0.0423
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0049	0.1806	0.3635
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0031	0.0795	0.1599
Echinococcus granulosus	nervana 2	0.0046	0.1648	0.1648
Echinococcus multilocularis	nervana 2	0.0046	0.1648	0.1648
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.313	0.6299
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0277	0.0557
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0038	0.1167	0.1919
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.007	0.2956	0.2956
Schistosoma mansoni	atypical protein kinase C	0.0025	0.0423	0.0423
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0113	0.5383	0.6094
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0025	0.0423	0.0423
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0074	0.3211	0.3211
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0074	0.3179	0.6399

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6500 nM	Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins	ChEMBL.	24094436

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2442463

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1791134