TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 288.729 | Formula: C15H13ClN2O2
H donors: 2 H acceptors: 2 LogP: 4.02 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)O)C(=O)N/N=C/c1ccccc1Cl
InChi: 1S/C15H13ClN2O2/c1-10-6-7-12(14(19)8-10)15(20)18-17-9-11-4-2-3-5-13(11)16/h2-9,19H,1H3,(H,18,20)/b17-9+
InChiKey: YZDJXFLWOFFTJZ-RQZCQDPDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0994	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0484	0.0627
Echinococcus granulosus	chromobox protein 1	0.0073	0.1688	0.1688
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0874	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0994	0.1286
Brugia malayi	MH2 domain containing protein	0.0124	0.3221	0.417
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0874	0.0874
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.0718	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0276	0.7725	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0439	0.0439
Echinococcus multilocularis	chromobox protein 1	0.0073	0.1688	0.1688
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0098	0.2453	0.3144
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.2453	0.2453
Brugia malayi	chromobox protein homolog 3	0.0041	0.0744	0.0964
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0098	0.2453	1
Echinococcus granulosus	chromobox protein 1	0.0073	0.1688	0.1688
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.1396	0.1808
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0874	0.1131
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0628	0.0628
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.1688	0.2008
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0439	0.0568
Schistosoma mansoni	hypothetical protein	0.0353	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0994	0.1286
Schistosoma mansoni	chromobox protein	0.0073	0.1688	0.1688
Trypanosoma brucei	polo-like protein kinase	0.0098	0.2453	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.5958	0.7712
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0874	0.0874
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.2453	1
Brugia malayi	Heterochromatin protein 1	0.0073	0.1688	0.2186
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0461	0.0461
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0874	0.1131
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0439	0.0439
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0982	0.0913
Onchocerca volvulus		0.0043	0.0812	0.0583
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0461	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0043	0.0812	0.0812
Echinococcus multilocularis	chromobox protein 1	0.0073	0.1688	0.1688
Echinococcus granulosus	transcription factor Dp 1	0.004	0.0718	0.0718
Giardia lamblia	Kinase, PLK	0.0098	0.2453	1
Brugia malayi	PHD-finger family protein	0.003	0.0439	0.0568
Plasmodium falciparum	phd finger protein, putative	0.003	0.0439	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0439	0.0568
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2453	0.3193
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0982	0.0913
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0628	0.0628
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.3221	0.417
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0534	0.0691
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0461	0.0461
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0744	0.0545
Plasmodium vivax	SET domain protein, putative	0.0031	0.0461	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0461	0.0461
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.3221	0.417
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0098	0.2453	1
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0791	0.0791
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0874	0.0874
Schistosoma mansoni	hypothetical protein	0.003	0.0439	0.0439
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0098	0.2453	0.2453
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2453	0.3193
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.2484	0.2484
Echinococcus granulosus	peregrin	0.003	0.0439	0.0439
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0069	0.1576	0.1576
Brugia malayi	Bromodomain containing protein	0.003	0.0439	0.0568
Trichomonas vaginalis	set domain proteins, putative	0.0247	0.6844	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0461	0.0461
Brugia malayi	jmjC domain containing protein	0.0099	0.2484	0.3216
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0439	0.0439
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0836	0.0687
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0874	0.0874
Brugia malayi	NNMT/PNMT/TEMT family protein	0.0276	0.7725	1
Schistosoma mansoni	kinase	0.005	0.102	0.102
Onchocerca volvulus		0.0247	0.6844	1
Schistosoma mansoni	hypothetical protein	0.0353	1	1
Schistosoma mansoni	chromobox protein	0.0073	0.1688	0.1688
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0791	0.0791
Echinococcus multilocularis	peregrin	0.003	0.0439	0.0439
Echinococcus multilocularis	geminin	0.0353	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0628	0.0813
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.2453	1
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2453	0.3193
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2453	0.3193
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0628	0.0628
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0874	0.0874
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0994	0.1286
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0461	0.0461
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0874	0.0874
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.1879	0.1879
Brugia malayi	jmjC domain containing protein	0.0037	0.0628	0.0813
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.1688	0.2008
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2453	0.3193
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.0276	0.7725	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0534	0.0691
Schistosoma mansoni	hypothetical protein	0.0034	0.0534	0.0534
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2453	0.3193
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0461	0.0461
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0744	0.0545
Brugia malayi	Pre-SET motif family protein	0.0217	0.5958	0.7712
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2453	0.3193
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0744	0.0477
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0069	0.1576	0.1576
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.1688	0.2186
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0836	0.0619
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0628	0.0628
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0098	0.2453	0.3175
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0836	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1081	0.14
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0069	0.1576	0.204
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0427	0.0427
Brugia malayi	serine/threonine-protein kinase plk-2	0.0098	0.2453	0.3175
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0744	0.0964
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0069	0.1576	0.1576
Onchocerca volvulus		0.0032	0.0484	0.007
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0098	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0461	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0276	0.7725	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.2484	0.2484
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0069	0.1576	0.204
Brugia malayi	Pre-SET motif family protein	0.0031	0.0461	0.0596

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2297376

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1791344