Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0142 | 0.0366 | 0.0316 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0142 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0366 | 0.0366 |
Brugia malayi | PXA domain containing protein | 0.0142 | 0.0366 | 0.0316 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0146 | 0.0392 | 0.003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1428 | 1 | 1 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0142 | 0.0366 | 0.0316 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1428 | 1 | 1 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1286 | 0.8932 | 1 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0142 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | RGS-3 protein | 0.0142 | 0.0366 | 0.0366 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1286 | 0.8932 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0146 | 0.0392 | 0.0342 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1286 | 0.8932 | 0.8927 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1286 | 0.8932 | 0.8932 |
Schistosoma mansoni | regulator of G protein signaling | 0.0142 | 0.0366 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0052 | 0.0052 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0142 | 0.0366 | 0.0316 |
Schistosoma mansoni | axis inhibition protein axin | 0.0142 | 0.0366 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0366 | 0.0366 |
Schistosoma mansoni | regulator of G protein signaling | 0.0142 | 0.0366 | 0.0316 |
Brugia malayi | PXA domain containing protein | 0.0142 | 0.0366 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0146 | 0.0392 | 0.0392 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0142 | 0.0366 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0366 | 0.0366 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0146 | 0.0392 | 0.003 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0052 | 0.0052 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0142 | 0.0366 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0142 | 0.0366 | 0.0316 |
Schistosoma mansoni | regulator of G protein signaling | 0.0142 | 0.0366 | 0.0316 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0142 | 0.0366 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0366 | 0.0366 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0142 | 0.0366 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0366 | 0.0366 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0142 | 0.0366 | 0.0316 |
Brugia malayi | hypothetical protein | 0.0142 | 0.0366 | 0.0316 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Onchocerca volvulus | 0.0101 | 0.0052 | 0.5 | |
Onchocerca volvulus | 0.0101 | 0.0052 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0142 | 0.0366 | 0.0316 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0142 | 0.0366 | 0.0316 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0146 | 0.0392 | 0.0342 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0142 | 0.0366 | 0.0316 |
Schistosoma mansoni | regulator of G protein signaling | 0.0142 | 0.0366 | 0.0316 |
Onchocerca volvulus | 0.0101 | 0.0052 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0366 | 0.5 |
Brugia malayi | hypothetical protein | 0.0142 | 0.0366 | 0.0316 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1286 | 0.8932 | 0.8932 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 500 % | Type-1 positive allosteric modulation of human alpha7 nAChR expressed in Xenopus oocytes assessed as maximum modulation of nicotine EC5 response at 10 uM by two-electrode voltage clamp method relative to control | ChEMBL. | 24098954 |
EC50 (binding) | = 2.5 uM | Type-1 positive allosteric modulation of human alpha7 nAChR expressed in Xenopus oocytes assessed as maximum modulation of nicotine EC5 response by two-electrode voltage clamp method | ChEMBL. | 24098954 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.