Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.1083 | 0.6516 | 0.6516 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0249 | 0.1018 | 0.0689 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1611 | 1 | 1 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0249 | 0.1018 | 0.0689 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0249 | 0.1018 | 0.0689 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0249 | 0.1018 | 0.0689 |
Echinococcus granulosus | axis inhibition protein axin | 0.0249 | 0.1018 | 0.0689 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0148 | 0.0354 | 0.0354 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0249 | 0.1018 | 0.1018 |
Brugia malayi | PXA domain containing protein | 0.0249 | 0.1018 | 0.1347 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0249 | 0.1018 | 0.1347 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0249 | 0.1018 | 0.1347 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0249 | 0.1018 | 0.1018 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.1362 | 0.8359 | 0.8298 |
Echinococcus multilocularis | expressed protein | 0.0249 | 0.1018 | 0.0689 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.1362 | 0.8359 | 0.8298 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0148 | 0.0354 | 1 |
Brugia malayi | PXA domain containing protein | 0.0249 | 0.1018 | 0.1347 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0249 | 0.1018 | 0.0689 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0148 | 0.0354 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0249 | 0.1018 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.019 | 0.019 |
Entamoeba histolytica | hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0094 | 0 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0249 | 0.1018 | 0.1018 |
Schistosoma mansoni | axis inhibition protein axin | 0.0249 | 0.1018 | 0.1018 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0249 | 0.1018 | 0.0689 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0249 | 0.1018 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1018 | 0.1018 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0249 | 0.1018 | 0.0689 |
Brugia malayi | hypothetical protein | 0.0249 | 0.1018 | 0.1347 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1018 | 0.1018 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0249 | 0.1018 | 0.0689 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1611 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Brugia malayi | hypothetical protein | 0.0249 | 0.1018 | 0.1347 |
Entamoeba histolytica | hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0249 | 0.1018 | 0.1018 |
Echinococcus granulosus | alpha 16 mannosyl glycoprotein | 0.1241 | 0.756 | 0.7471 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.1611 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Brugia malayi | UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II | 0.1241 | 0.756 | 1 |
Echinococcus multilocularis | alpha 1,6 mannosyl glycoprotein | 0.1241 | 0.756 | 0.7471 |
Schistosoma mansoni | regulator of G protein signaling | 0.0249 | 0.1018 | 0.1018 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0249 | 0.1018 | 0.1018 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0249 | 0.1018 | 0.0689 |
Schistosoma mansoni | regulator of G protein signaling | 0.0249 | 0.1018 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1018 | 0.1018 |
Echinococcus granulosus | axis inhibition protein axin | 0.0249 | 0.1018 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1018 | 0.1018 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0249 | 0.1018 | 0.0689 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0834 | 0.4875 | 0.4687 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0094 | 0 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0148 | 0.0354 | 1 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0148 | 0.0354 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0249 | 0.1018 | 0.1018 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1083 | 0.6516 | 0.8619 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0249 | 0.1018 | 0.1347 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0094 | 0 | 0.5 |
Brugia malayi | diacylglycerol acyltransferase | 0.0148 | 0.0354 | 0.0468 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0834 | 0.4875 | 0.6448 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0249 | 0.1018 | 0.1347 |
Loa Loa (eye worm) | hypothetical protein | 0.1241 | 0.756 | 0.756 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0249 | 0.1018 | 0.1018 |
Schistosoma mansoni | regulator of G protein signaling | 0.0249 | 0.1018 | 0.1018 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0249 | 0.1018 | 0.1018 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0249 | 0.1018 | 0.1347 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0834 | 0.4875 | 0.4687 |
Loa Loa (eye worm) | RGS-3 protein | 0.0249 | 0.1018 | 0.1018 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0249 | 0.1018 | 0.0689 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0249 | 0.1018 | 0.0689 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0834 | 0.4875 | 0.4875 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0834 | 0.4875 | 0.4875 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0249 | 0.1018 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0148 | 0.0354 | 0.0354 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1083 | 0.6516 | 0.6516 |
Echinococcus granulosus | expressed protein | 0.0249 | 0.1018 | 0.0689 |
Schistosoma mansoni | regulator of G protein signaling | 0.0249 | 0.1018 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1018 | 0.1018 |
Schistosoma mansoni | beta-12-n-acetylglucosaminyltransferase II | 0.1241 | 0.756 | 0.756 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.1611 | 1 | 1 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0249 | 0.1018 | 0.5 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0249 | 0.1018 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.1018 | 0.1018 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Escherichia coli CCARM 1356 assessed as growth inhibition after 20 hr by two-fold serial dilution method | ChEMBL. | No reference |
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Escherichia coli CCARM 1924 assessed as growth inhibition after 20 hr by two-fold serial dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.