TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 690.845 | Formula: C38H46N2O8S
H donors: 1 H acceptors: 5 LogP: 4.5 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CS(=O)(=O)O.CC(CCOC(=O)c1ccccc1c1ccc(cc1)CN1CCC(CC1)COC(=O)c1c2ccccc2n2c1OCCC2)C
InChi: 1S/C37H42N2O5.CH4O3S/c1-26(2)18-23-43-36(40)31-9-4-3-8-30(31)29-14-12-27(13-15-29)24-38-20-16-28(17-21-38)25-44-37(41)34-32-10-5-6-11-33(32)39-19-7-22-42-35(34)39;1-5(2,3)4/h3-6,8-15,26,28H,7,16-25H2,1-2H3;1H3,(H,2,3,4)
InChiKey: YYEPQJLGHSWCKQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0046	0.0082	0.0084
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0046	0.0082	0.0028
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	TK/ABL protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0046	0.0082	0.0028
Brugia malayi	SRC-1	0.0046	0.0082	0.0084
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Brugia malayi	Raf kinase	0.0046	0.0082	0.0084
Echinococcus multilocularis	tyrosine protein kinase csk	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Loa Loa (eye worm)	TK/ROR protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0103	0.0056
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase csk	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	pyruvate kinase	0.0075	0.0181	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	pyruvate kinase	0.0059	0.0126	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Echinococcus multilocularis	tyrosine protein kinase	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Plasmodium falciparum	protein kinase, putative	0.0046	0.0082	0.2172
Echinococcus granulosus	tyrosine protein kinase csk	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0046	0.0082	0.0028
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0075	0.0181	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0046	0.0082	0.2172
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0046	0.0082	0.2172
Loa Loa (eye worm)	TK/INSR protein kinase	0.0046	0.0082	0.0035
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	epidermal growth factor receptor	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0082	0.0028
Echinococcus multilocularis	protein tyrosine kinase	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine protein kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Entamoeba histolytica	hypothetical protein	0.008	0.0199	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine kinase	0.0046	0.0082	0.0028
Plasmodium falciparum	tyrosine kinase-like protein	0.0046	0.0082	0.2172
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0046	0.0082	0.0028
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0046	0.0082	0.0028
Echinococcus multilocularis	activin receptor type	0.0046	0.0082	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Loa Loa (eye worm)	TK/CSK protein kinase	0.0046	0.0082	0.0035
Onchocerca volvulus	Pyruvate kinase homolog	0.0075	0.0181	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0046	0.0082	0.0084
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0046	0.0082	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Leishmania major	pyruvate kinase	0.0075	0.0181	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0046	0.0082	0.0028
Echinococcus multilocularis	activated cdc42 kinase 1	0.0046	0.0082	0.0028
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.008	0.0199	0.0148
Schistosoma mansoni	pyruvate kinase	0.0075	0.0181	0.0134
Entamoeba histolytica	hypothetical protein	0.008	0.0199	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase Blk	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0181	0.0136
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	TK/Met protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	natriuretic peptide receptor 1	0.0046	0.0082	0.0028
Echinococcus granulosus	raf serine:threonine protein kinase	0.0046	0.0082	0.0028
Brugia malayi	hypothetical protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	protein kinase	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Brugia malayi	hypothetical protein	0.008	0.0199	0.0203
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0046	0.0082	0.0034
Echinococcus granulosus	protein kinase	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase csk	0.0046	0.0082	0.0028
Toxoplasma gondii	STE kinase	0.0046	0.0082	0.2172
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0046	0.0082	0.0028
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0046	0.0082	0.0035
Echinococcus granulosus	ephrin type A receptor 4 A	0.0046	0.0082	0.0028
Loa Loa (eye worm)	pyruvate kinase-PB	0.0052	0.0103	0.0056
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0046	0.0082	0.0028
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0046	0.0082	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK/DDR protein kinase	0.0046	0.0082	0.0035
Plasmodium falciparum	protein kinase, putative	0.0046	0.0082	0.2172
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0046	0.0082	0.0028
Echinococcus multilocularis	FL cytokine receptor	0.0046	0.0082	0.0028
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Echinococcus granulosus	tyrosine kinase	0.0046	0.0082	0.0028
Echinococcus granulosus	epidermal growth factor receptor	0.0046	0.0082	0.0028
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Brugia malayi	C-terminal src kinase protein 1	0.0046	0.0082	0.0084
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Toxoplasma gondii	protein kinase domain-containing protein	0.0046	0.0082	0.2172
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Giardia lamblia	Kinase, NEK	0.0046	0.0082	0.2172
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	serine/threonine protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0107	0.006
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Echinococcus granulosus	pyruvate kinase	0.0075	0.0181	0.0129
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0082	0.0028
Echinococcus granulosus	epidermal growth factor receptor	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0046	0.0082	0.0028
Schistosoma mansoni	pyruvate kinase	0.0075	0.0181	0.0134
Trypanosoma brucei	pyruvate kinase 1	0.0075	0.0181	1
Brugia malayi	integrin-linked kinase	0.0046	0.0082	0.0084
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.008	0.0199	0.0148
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0046	0.0082	0.0028
Entamoeba histolytica	hypothetical protein	0.008	0.0199	1
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0075	0.0181	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0075	0.0181	1
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0046	0.0082	0.0034
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0046	0.0082	0.0028
Trypanosoma brucei	pyruvate kinase 1, putative	0.0075	0.0181	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0046	0.0082	0.2172
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.2861	0.9839	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0046	0.0082	0.0035
Echinococcus multilocularis	insulin receptor	0.0046	0.0082	0.0028
Brugia malayi	Guanylyl cyclase protein 23	0.0046	0.0082	0.0084
Brugia malayi	Tyrosine-protein kinase PR2	0.0046	0.0082	0.0084
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0046	0.0082	0.0028
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine kinase	0.0046	0.0082	0.0028
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0046	0.0082	0.0084
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	receptor type guanylyl cyclase	0.0046	0.0082	0.0028
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	serine/threonine RGC	0.0046	0.0082	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0046	0.0082	0.2172
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	SRC-1	0.0046	0.0082	0.0035
Echinococcus multilocularis	integrin linked protein kinase	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0046	0.0082	0.0028
Giardia lamblia	Protein 21.1	0.0046	0.0082	0.2172
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0046	0.0082	0.0028
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0046	0.0082	0.0028
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0082	0.0034
Echinococcus multilocularis	tyrosine protein kinase csk	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK/ALK protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0046	0.0082	0.0028
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0046	0.0082	0.0028
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0075	0.0181	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Trichomonas vaginalis	pyruvate kinase, putative	0.0075	0.0181	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0046	0.0082	0.0035
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0046	0.0082	0.0028
Schistosoma mansoni	ephrin receptor	0.0046	0.0082	0.0034
Echinococcus multilocularis	c src tyrosine kinase	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Entamoeba histolytica	hypothetical protein	0.008	0.0199	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0046	0.0082	0.0028
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0107	0.0108
Echinococcus multilocularis	tyrosine protein kinase csk	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Schistosoma mansoni	hypothetical protein	0.008	0.0199	0.0152
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	0.0363	0.0321
Brugia malayi	ephrin receptor 1 precursor	0.0046	0.0082	0.0084
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0046	0.0082	0.0035
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0107	0.0108
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0046	0.0082	0.0028
Toxoplasma gondii	pyruvate kinase PyK1	0.0075	0.0181	1
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0046	0.0082	0.0035
Brugia malayi	hypothetical protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase csk	0.0046	0.0082	0.0028
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0046	0.0082	0.0084
Giardia lamblia	Pyruvate kinase	0.0075	0.0181	1
Schistosoma mansoni	ephrin receptor	0.0046	0.0082	0.0034
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0046	0.0082	0.0028
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0046	0.0082	0.0028
Echinococcus granulosus	kinase suppressor of Ras 1	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0046	0.0082	0.0034
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	pyruvate kinase	0.0038	0.0055	0.0007
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0046	0.0082	0.0028
Echinococcus multilocularis	protein kinase	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0046	0.0082	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0107	0.006
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0046	0.0082	0.0084
Loa Loa (eye worm)	TK/FAK protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Onchocerca volvulus	Pyruvate kinase homolog	0.0075	0.0181	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0046	0.0082	0.0035
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0046	0.0082	0.0028
Giardia lamblia	Kinase	0.0046	0.0082	0.2172
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Brugia malayi	SH2 domain containing protein	0.0046	0.0082	0.0084
Echinococcus granulosus	activated cdc42 kinase 1	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK/ACK protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	integrin linked protein kinase	0.0046	0.0082	0.0028
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0046	0.0082	0.0035
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Echinococcus multilocularis	heat shock protein 70	0.0046	0.0082	0.0028
Schistosoma mansoni	protein tyrosine kinase	0.0046	0.0082	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0046	0.0082	0.0028
Echinococcus multilocularis	tyrosine protein kinase shark	0.0046	0.0082	0.0028
Toxoplasma gondii	protein kinase	0.0046	0.0082	0.2172
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	protein tyrosine kinase	0.0046	0.0082	0.0028
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0075	0.0181	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0075	0.0181	0.0184
Brugia malayi	Protein kinase domain containing protein	0.2861	0.9839	1
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Echinococcus multilocularis	pyruvate kinase	0.0075	0.0181	0.0129
Chlamydia trachomatis	pyruvate kinase	0.0075	0.0181	0.5
Loa Loa (eye worm)	hypothetical protein	0.2861	0.9839	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0048	0.0049
Echinococcus granulosus	tyrosine protein kinase Srms	0.0046	0.0082	0.0028
Onchocerca volvulus	Pyruvate kinase homolog	0.0075	0.0181	1
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0046	0.0082	0.0035
Plasmodium vivax	pyruvate kinase, putative	0.0075	0.0181	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0046	0.0082	0.2172
Echinococcus granulosus	tyrosine protein kinase pr2	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.2861	0.9839	1
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Brugia malayi	MH2 domain containing protein	0.0127	0.0363	0.0369
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0046	0.0082	0.0035
Brugia malayi	Tyrosine-protein kinase abl-1	0.0046	0.0082	0.0084
Loa Loa (eye worm)	hypothetical protein	0.2861	0.9839	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Schistosoma mansoni	transcription factor LCR-F1	0.008	0.0199	0.0152
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0046	0.0082	0.0028
Echinococcus granulosus	activin receptor type	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	0.0363	0.0321
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0046	0.0082	0.0084
Brugia malayi	protein-tyrosine kinase	0.0046	0.0082	0.0084
Plasmodium vivax	protein kinase, putative	0.0046	0.0082	0.2172
Plasmodium falciparum	protein kinase, putative	0.0046	0.0082	0.2172
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase shark	0.0046	0.0082	0.0028
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0046	0.0082	0.0028
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Echinococcus multilocularis	epidermal growth factor receptor	0.0046	0.0082	0.0028
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0046	0.0082	0.0084
Echinococcus granulosus	tyrosine kinase	0.0046	0.0082	0.0028
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase HCK	0.0046	0.0082	0.0028
Brugia malayi	SH2 domain containing protein	0.0046	0.0082	0.0084
Brugia malayi	hypothetical protein	0.0046	0.0082	0.0084
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Loa Loa (eye worm)	TK/RYK protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Schistosoma mansoni	tyrosine kinase	0.0046	0.0082	0.0034
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0046	0.0082	0.0028
Schistosoma mansoni	hypothetical protein	0.0046	0.0082	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Loa Loa (eye worm)	pyruvate kinase	0.0075	0.0181	0.0136
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0046	0.0082	0.2172
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0046	0.0082	0.0028
Echinococcus granulosus	pyruvate kinase	0.0075	0.0181	0.0129
Loa Loa (eye worm)	TK/EPH protein kinase	0.0046	0.0082	0.0035
Plasmodium falciparum	pyruvate kinase	0.0075	0.0181	1
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus granulosus	c src tyrosine kinase	0.0046	0.0082	0.0028
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Leishmania major	pyruvate kinase	0.0075	0.0181	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	pyruvate kinase	0.0075	0.0181	0.0129
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0046	0.0082	0.0028
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0075	0.0181	0.0184
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0046	0.0082	0.0084
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0046	0.0082	0.0028
Echinococcus granulosus	insulin receptor	0.0046	0.0082	0.0028
Echinococcus granulosus	tyrosine protein kinase	0.0046	0.0082	0.0028
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.2861	0.9839	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0046	0.0082	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0046	0.0082	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.0035
Entamoeba histolytica	pyruvate kinase, putative	0.0052	0.0103	0.1738
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0046	0.0082	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Schistosoma mansoni	protein kinase	0.0046	0.0082	0.0034
Loa Loa (eye worm)	pyruvate kinase	0.0075	0.0181	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0082	0.0084
Echinococcus granulosus	tyrosine kinase	0.0046	0.0082	0.0028
Brugia malayi	Receptor family ligand binding region containing protein	0.0046	0.0082	0.0084
Mycobacterium ulcerans	pyruvate kinase	0.0075	0.0181	0.5
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0082	0.0035
Echinococcus granulosus	activated cdc42 kinase 1	0.0046	0.0082	0.0028
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0082	0.0034
Giardia lamblia	Kinase, NEK	0.0046	0.0082	0.2172
Echinococcus multilocularis	transfer RNA-Thr	0.0046	0.0082	0.0028
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0046	0.0082	0.0034

Activities

Activity type	Activity value	Assay description	Source	Reference
Papp (ADMET)	= 5.4 ucm/s	Apparent permeability of the compound in human Caco2 cells at 1 uM	ChEMBL.	24113240

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2440465

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1792818