Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1485 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0133 | 0.0182 |
Echinococcus multilocularis | SWI:SNF complex subunit SMARCC2 | 0.0085 | 0.0305 | 0.0418 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0294 | 0.1755 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0294 | 0.1755 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0294 | 0.1755 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0085 | 0.0305 | 0.0358 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.1095 | 0.7302 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0294 | 0.1755 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0294 | 0.1755 | 0.5 |
Giardia lamblia | hypothetical protein | 0.0085 | 0.0305 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0294 | 0.1755 | 0.2404 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0085 | 0.0305 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.119 | 0.7961 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0294 | 0.1755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.118 | 0.7891 | 1 |
Schistosoma mansoni | amine oxidase | 0.0294 | 0.1755 | 0.2404 |
Echinococcus multilocularis | 0.0294 | 0.1755 | 0.2404 | |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0294 | 0.1755 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0294 | 0.1755 | 0.2404 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0055 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.1755 | 0.217 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0294 | 0.1755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0133 | 0.01 |
Schistosoma mansoni | amine oxidase | 0.0294 | 0.1755 | 0.2404 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0305 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.2344 | 0.2922 |
Schistosoma mansoni | SWI/SNF complex-related | 0.0085 | 0.0305 | 0.0418 |
Entamoeba histolytica | SWIRM domain protein | 0.0085 | 0.0305 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.1095 | 0.7302 | 1 |
Onchocerca volvulus | 0.118 | 0.7891 | 0.5 | |
Brugia malayi | SWIRM domain containing protein | 0.118 | 0.7891 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0101 | 0.0139 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0294 | 0.1755 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0379 | 0.2344 | 0.295 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0294 | 0.1755 | 0.2404 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.1755 | 0.217 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.1095 | 0.7302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1095 | 0.7302 | 0.9248 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0294 | 0.1755 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0294 | 0.1755 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0294 | 0.1755 | 0.5 |
Brugia malayi | hypothetical protein | 0.0294 | 0.1755 | 0.2202 |
Entamoeba histolytica | SWIRM domain protein | 0.0085 | 0.0305 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0294 | 0.1755 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0.0305 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0294 | 0.1755 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0085 | 0.0305 | 0.5 |
Echinococcus granulosus | SWI:SNF complex subunit SMARCC2 | 0.0085 | 0.0305 | 0.0418 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0133 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.1095 | 0.7302 | 0.9248 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 1.6 % | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization at 30 uM preincubated for 140 seconds prior to glutamate-stimulation measured after 60 seconds relative to glutamate | ChEMBL. | 24074843 |
IC50 (binding) | = 6.3 | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization preincubated for 140 seconds prior to glutamate-stimulation measured after 60 seconds | ChEMBL. | 24074843 |
IC50 (binding) | = 502 nM | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization preincubated for 140 seconds prior to glutamate-stimulation measured after 60 seconds | ChEMBL. | 24074843 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.