Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peptidylglycine monooxygenase | 0.012 | 0.4858 | 0.4858 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.1596 | 0.1596 |
Echinococcus granulosus | calpain A | 0.0055 | 0.1712 | 0.1712 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 0.5491 | 0.5491 |
Echinococcus multilocularis | cathepsin b | 0.0133 | 0.5491 | 0.5491 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.1712 | 0.1712 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1305 | 0.1305 |
Echinococcus multilocularis | cathepsin b | 0.0133 | 0.5491 | 0.5491 |
Onchocerca volvulus | 0.0033 | 0.0629 | 0.5 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0044 | 0.1164 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0061 | 0.1989 | 0.1989 |
Loa Loa (eye worm) | cathepsin B | 0.0044 | 0.1164 | 0.1164 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0053 | 0.1596 | 0.1596 |
Plasmodium vivax | calpain, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0053 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.5491 | 0.5491 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0044 | 0.1164 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.4858 | 0.4858 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.092 | 0.092 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0044 | 0.1164 | 0.2121 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0133 | 0.5491 | 0.5491 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0055 | 0.1712 | 0.1712 |
Echinococcus granulosus | cathepsin b | 0.0133 | 0.5491 | 0.5491 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0629 | 0.0629 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0039 | 0.092 | 0.092 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.1164 | 0.5 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.012 | 0.4858 | 0.4858 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0044 | 0.1164 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0044 | 0.1164 | 0.1164 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0225 | 1 | 1 |
Toxoplasma gondii | cathepsin B | 0.0044 | 0.1164 | 0.5 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.1712 | 0.1712 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0059 | 0.1902 | 0.1902 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.1712 | 0.1712 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0039 | 0.092 | 0.092 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.1164 | 0.5 |
Echinococcus multilocularis | calpain A | 0.0055 | 0.1712 | 0.1712 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 0.5491 | 0.5491 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0225 | 1 | 1 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0225 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0133 | 0.5491 | 0.5491 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0133 | 0.5491 | 0.5491 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0133 | 0.5491 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 0.5491 | 0.5491 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.012 | 0.4858 | 0.4858 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1596 | 0.1596 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.1164 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 14.5 nM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen infected in 3T3 cells after 7 days by beta-galactosidase assay | ChEMBL. | 24120539 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 24120539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.