Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1961 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0255 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0255 | 0 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1961 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0255 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0268 | 0.0081 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1961 | 1 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1961 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1961 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0265 | 0.0062 | 0.5 |
Echinococcus granulosus | protein tyrosine kinase | 0.0265 | 0.0062 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1961 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1961 | 1 | 0.5 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0265 | 0.0062 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0255 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0268 | 0.0081 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0255 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 49.5 uM | Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis | ChEMBL. | 24113239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.