Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.0999 | 1 |
Schistosoma mansoni | beta-galactosidase | 0.0644 | 0.4122 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0588 | 0.3615 | 1 |
Loa Loa (eye worm) | trehalase | 0.0289 | 0.0909 | 0.0909 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0289 | 0.0909 | 0.9035 |
Echinococcus granulosus | beta galactosidase | 0.0644 | 0.4122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.0909 | 0.0909 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0207 | 0.0162 | 0.1027 |
Echinococcus multilocularis | beta galactosidase | 0.0644 | 0.4122 | 1 |
Onchocerca volvulus | Trehalase homolog | 0.0289 | 0.0909 | 0.468 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.0999 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0197 | 0.0069 | 0.5 |
Loa Loa (eye worm) | TRE-1 protein | 0.0289 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.0644 | 0.4122 | 0.4122 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.0999 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.0999 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0197 | 0.0069 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.0999 | 1 |
Onchocerca volvulus | 0.0289 | 0.0909 | 0.468 | |
Onchocerca volvulus | 0.0289 | 0.0909 | 0.468 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.0999 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | TRE-2 protein | 0.0289 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | trehalase | 0.0289 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0588 | 0.3615 | 0.3615 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0207 | 0.0162 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.0909 | 0.0909 |
Onchocerca volvulus | 0.0289 | 0.0909 | 0.468 | |
Onchocerca volvulus | 0.0395 | 0.1867 | 1 | |
Onchocerca volvulus | 0.0289 | 0.0909 | 0.468 | |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0299 | 0.0999 | 0.0999 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0299 | 0.0999 | 0.0333 |
Trichomonas vaginalis | trehalase, putative | 0.0289 | 0.0909 | 0.9035 |
Onchocerca volvulus | 0.0289 | 0.0909 | 0.468 | |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | trehalase | 0.0289 | 0.0909 | 0.0909 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 8739 after 18 hrs by agar dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.