TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 344.383 | Formula: C18H21FN4O2
H donors: 2 H acceptors: 4 LogP: 2.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(NC(=O)c1nc(C)c(nc1C(=O)Nc1cc(F)ccc1C)C)C
InChi: 1S/C18H21FN4O2/c1-9(2)20-17(24)15-16(22-12(5)11(4)21-15)18(25)23-14-8-13(19)7-6-10(14)3/h6-9H,1-5H3,(H,20,24)(H,23,25)
InChiKey: WDOYGPHOXYXIGB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	heat shock protein 90, putative	0.0034	0.025	0.0964
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0034	0.025	0.025
Echinococcus multilocularis	heat shock protein	0.0034	0.025	0.025
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0112	0.0112
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0173	0.0095
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.025	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0034	0.025	0.038
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0034	0.025	1
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0034	0.025	1
Leishmania major	DNA topoisomerase ii	0.0034	0.025	0.0213
Toxoplasma gondii	heat shock protein HSP90	0.0034	0.025	0.0964
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0173	0.6929
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0034	0.025	1
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.00000034704	0.00000040868
Loa Loa (eye worm)	hypothetical protein	0.002	0.0098	0.0149
Chlamydia trachomatis	DNA gyrase subunit B	0.0034	0.025	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0579	0.6204	0.7306
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0034	0.025	1
Loa Loa (eye worm)	heat shock protein 90	0.0034	0.025	0.038
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0112	0.017
Schistosoma mansoni	endoplasmin	0.0034	0.025	0.0294
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.025	1
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0034	0.025	1
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0034	0.025	0.0964
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0034	0.025	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0112	0.4479
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0034	0.025	1
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0226	0.2343	0.2343
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0173	0.5311
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0112	0.4479
Trichomonas vaginalis	receptor histidine kinase, putative	0.0034	0.025	1
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0098	0.3933
Brugia malayi	kinase, mitochondrial precursor	0.0613	0.6577	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0173	0.6929
Schistosoma mansoni	DNA topoisomerase II	0.0034	0.025	0.0294
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.00000034704	0.00000034704
Brugia malayi	heat shock protein 90	0.0034	0.025	0.038
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Echinococcus granulosus	heat shock protein	0.0034	0.025	0.0294
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0173	0.0263
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0112	0.0132
Schistosoma mansoni	ap endonuclease	0.0021	0.0112	0.0132
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0034	0.025	1
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0034	0.025	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0112	0.1571
Echinococcus multilocularis	microtubule associated protein 2	0.0789	0.8492	0.8492
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.2343	0.2759
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0034	0.025	0.038
Leishmania major	hypothetical protein, conserved	0.0034	0.025	0.0213
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0034	0.025	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.025	0.038
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Trichomonas vaginalis	endoplasmin, putative	0.0034	0.025	1
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0034	0.025	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0034	0.025	0.0964
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0034	0.025	1
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0034	0.025	1
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0034	0.025	0.0294
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Trypanosoma brucei	heat shock protein, putative	0.0034	0.025	0.038
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0034	0.025	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0173	0.6929
Echinococcus multilocularis	heat shock protein 90	0.0034	0.025	0.025
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0112	0.4479
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0034	0.025	1
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0098	0.3933
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0034	0.025	1
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0034	0.025	0.038
Plasmodium vivax	DNA gyrase subunit B, putative	0.0034	0.025	1
Trypanosoma brucei	heat shock protein, putative	0.0034	0.025	0.038
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0613	0.6577	1
Brugia malayi	Stress-activated protein kinase jnk-1	0.0226	0.2343	0.3562
Plasmodium falciparum	heat shock protein 90	0.0034	0.025	1
Brugia malayi	Probable DNA topoisomerase II	0.0034	0.025	0.038
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0098	0.3933
Mycobacterium ulcerans	DNA gyrase subunit B	0.0034	0.025	1
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Plasmodium vivax	heat shock protein 86, putative	0.0034	0.025	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0173	0.6929
Loa Loa (eye worm)	TOPoisomerase family member	0.0034	0.025	0.038
Trypanosoma brucei	heat shock protein, putative	0.0034	0.025	0.038
Giardia lamblia	Pms1-like protein	0.0034	0.025	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0173	0.0095
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0173	0.6929
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0173	0.6929
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0112	0.4479
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.00000034704	0.000001339
Loa Loa (eye worm)	endoplasmin	0.0034	0.025	0.038
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0034	0.025	1
Trypanosoma brucei	heat shock protein, putative	0.0034	0.025	0.038
Onchocerca volvulus		0.0027	0.0173	0.6929
Loa Loa (eye worm)	hypothetical protein	0.0613	0.6577	1
Mycobacterium ulcerans	two component sensor kinase MprB	0.0034	0.025	1
Trypanosoma brucei	heat shock protein, putative	0.0034	0.025	0.038
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0034	0.025	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0613	0.6577	0.7745
Echinococcus granulosus	microtubule associated protein 2	0.0789	0.8492	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0112	0.4479
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0034	0.025	1
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0034	0.025	1
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0613	0.6577	1
Echinococcus granulosus	c-Jun N-terminal kinases	0.0226	0.2343	0.2759
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0034	0.025	1
Trypanosoma brucei	heat shock protein, putative	0.0034	0.025	0.038
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0034	0.025	0.038
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0173	0.0095
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.025	1
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.025	0.038
Loa Loa (eye worm)	hypothetical protein	0.002	0.0098	0.0149
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0034	0.025	1
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.025	0.038
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0098	0.3933
Trichomonas vaginalis	sensor histidine kinase, putative	0.0034	0.025	1
Trypanosoma brucei	heat shock protein, putative	0.0034	0.025	0.038
Plasmodium falciparum	DNA topoisomerase 2	0.0034	0.025	1
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0173	0.0263
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0112	0.4479
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.025	1
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0034	0.025	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0112	0.017
Plasmodium falciparum	DNA gyrase subunit B	0.0034	0.025	1
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0034	0.025	1
Entamoeba histolytica	DNA topoisomerase II, putative	0.0034	0.025	1
Trypanosoma brucei	heat shock protein, putative	0.0034	0.025	0.038
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0034	0.025	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0173	0.6929
Schistosoma mansoni	ap endonuclease	0.0021	0.0112	0.0132
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0034	0.025	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0098	0.0149
Schistosoma mansoni	heat shock protein	0.0034	0.025	0.0294
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0214	0.2219	0.3374
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0034	0.025	0.038
Plasmodium falciparum	endoplasmin, putative	0.0034	0.025	1
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0173	0.0263
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0034	0.025	1
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0034	0.025	1
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0214	0.2219	0.3374
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0173	0.6929
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0034	0.025	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0034	0.025	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0248	0.2592	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0173	0.6929
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.025	0.038
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0034	0.025	1
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0214	0.2219	0.326
Chlamydia trachomatis	DNA gyrase subunit B	0.0034	0.025	1
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0034	0.025	1
Plasmodium vivax	endoplasmin, putative	0.0034	0.025	1
Trichomonas vaginalis	receptor histidine kinase, putative	0.0034	0.025	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0098	0.0738
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.025	0.038
Plasmodium vivax	DNA topoisomerase II, putative	0.0034	0.025	1
Schistosoma mansoni	endoplasmin	0.0034	0.025	0.0294
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0613	0.6577	0.6577
Trypanosoma cruzi	Heat shock protein 83, putative	0.0034	0.025	0.038
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0034	0.025	1
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0034	0.025	1
Trypanosoma brucei	Heat shock protein 83, putative	0.0034	0.025	0.038
Mycobacterium leprae	Probable two-component sensor kinase	0.0034	0.025	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.025	0.038
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0034	0.025	0.038
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0112	0.4479
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0613	0.6577	0.7745
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0034	0.025	1
Echinococcus granulosus	heat shock protein 90	0.0034	0.025	0.0294
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0613	0.6577	0.6577
Mycobacterium ulcerans	putative regultory protein	0.0034	0.025	1
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0034	0.025	1
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.00000034704	0.00000040868
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0173	0.0263
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0034	0.025	0.038
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0173	0.0263
Toxoplasma gondii	exonuclease III APE	0.0021	0.0112	0.0432
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0613	0.6577	1
Trypanosoma brucei	DNA topoisomerase ii	0.0034	0.025	0.038
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0034	0.025	0.0964
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0034	0.025	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0173	0.6929
Brugia malayi	Endoplasmin precursor	0.0034	0.025	0.038
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0034	0.025	1
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0112	0.4479
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0173	0.0263
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0173	0.5311
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0034	0.025	0.038
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0112	0.017
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.025	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0579	0.6204	0.7306
Leishmania major	mitochondrial DNA topoisomerase II	0.0034	0.025	0.0213
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0034	0.025	0.038
Loa Loa (eye worm)	hypothetical protein	0.002	0.0098	0.0149
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0034	0.025	0.038
Schistosoma mansoni	heat shock protein	0.0034	0.025	0.0294
Loa Loa (eye worm)	hypothetical protein	0.002	0.0098	0.0149
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0034	0.025	0.038
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0034	0.025	1
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0034	0.025	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0173	0.6929
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0112	0.017
Mycobacterium tuberculosis	Conserved protein	0.0034	0.025	1
Schistosoma mansoni	microtubule-associated protein tau	0.0789	0.8492	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0112	0.4479
Trypanosoma cruzi	heat shock protein 90, putative	0.0034	0.025	0.038
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0034	0.025	1
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0214	0.2219	0.8562
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0173	0.6929
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0226	0.2343	0.3562
Loa Loa (eye worm)	hypothetical protein	0.0034	0.025	0.038
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0034	0.025	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0112	0.017
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0173	0.6929
Leishmania major	heat shock protein 83-1	0.0034	0.025	0.0213

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2286633

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1799194