Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | P2X receptor subunit | 0.0275 | 0.3857 | 0.3857 |
Trichomonas vaginalis | ssf, putative | 0.0123 | 0.0522 | 0.5 |
Onchocerca volvulus | 0.0214 | 0.2531 | 1 | |
Trypanosoma brucei | brix domain containing protein, putative | 0.0123 | 0.0522 | 0.5 |
Echinococcus multilocularis | peter pan | 0.0123 | 0.0522 | 0.0522 |
Schistosoma mansoni | P2X receptor subunit | 0.0554 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0554 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0554 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0275 | 0.3857 | 0.3857 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0554 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein 598 | 0.0122 | 0.0505 | 0.0505 |
Trypanosoma cruzi | peter pan protein, putative | 0.0123 | 0.0522 | 0.5 |
Leishmania major | peter pan protein, putative | 0.0123 | 0.0522 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.0123 | 0.0522 | 0.0522 |
Brugia malayi | Brix domain containing protein | 0.0123 | 0.0522 | 0.2062 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0554 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0554 | 1 | 1 |
Entamoeba histolytica | brix domain containing protein | 0.0123 | 0.0522 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.2531 | 0.2531 |
Trypanosoma cruzi | peter pan protein, putative | 0.0123 | 0.0522 | 0.5 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0214 | 0.2531 | 1 |
Schistosoma mansoni | peter pan-related | 0.0123 | 0.0522 | 0.0522 |
Giardia lamblia | Peter pan protein | 0.0123 | 0.0522 | 0.5 |
Echinococcus granulosus | peter pan | 0.0123 | 0.0522 | 0.0522 |
Onchocerca volvulus | Peter pan protein homolog | 0.0123 | 0.0522 | 0.2062 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0214 | 0.2531 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0554 | 1 | 1 |
Toxoplasma gondii | brix domain-containing protein | 0.0123 | 0.0522 | 0.5 |
Plasmodium falciparum | BRIX domain, putative | 0.0123 | 0.0522 | 0.5 |
Echinococcus granulosus | zinc finger protein 598 | 0.0122 | 0.0505 | 0.0505 |
Plasmodium vivax | hypothetical protein, conserved | 0.0123 | 0.0522 | 0.5 |
Loa Loa (eye worm) | brix domain-containing protein | 0.0123 | 0.0522 | 0.2062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 41 uM | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA | ChEMBL. | 25221661 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.