Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family C13 non-peptidase homologue (C13 family) | 0.2896 | 1 | 1 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.2896 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.0146 | 0.0046 |
Brugia malayi | GPI-anchor transamidase | 0.0672 | 0.2175 | 0.2059 |
Onchocerca volvulus | Legumain homolog | 0.2896 | 1 | 0.5 |
Trypanosoma brucei | GPI-anchor transamidase subunit 8 (GPI8) | 0.0672 | 0.2175 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.2896 | 1 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.0421 | 0.1936 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.2896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0146 | 0.0095 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.0421 | 0.1356 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.2896 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.2896 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CD, family C13, putative | 0.0672 | 0.2175 | 1 |
Loa Loa (eye worm) | peptidase C13 family protein | 0.2896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.2175 | 0.2135 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.0146 | 0.0671 |
Entamoeba histolytica | GPI-anchor transamidase, putative | 0.0672 | 0.2175 | 1 |
Toxoplasma gondii | peptidase c13 family protein | 0.0672 | 0.2175 | 1 |
Echinococcus multilocularis | GPI anchor transamidase | 0.0672 | 0.2175 | 1 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.0421 | 0.0279 |
Plasmodium falciparum | GPI-anchor transamidase, putative | 0.0672 | 0.2175 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0275 | 0.0225 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.0421 | 0.0324 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.2896 | 1 | 1 |
Leishmania major | GPI-anchor transamidase subunit 8 (GPI8), putative | 0.0672 | 0.2175 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.2224 | 0.7636 | 0.7612 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.2896 | 1 | 1 |
Echinococcus granulosus | GPI anchor transamidase | 0.0672 | 0.2175 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.2896 | 1 | 1 |
Schistosoma mansoni | glycosylphosphatidylinositol:protein transamidase (C13 family) | 0.0672 | 0.2175 | 0.2095 |
Plasmodium vivax | GPI-anchor transamidase, putative | 0.0672 | 0.2175 | 0.5 |
Giardia lamblia | GPI-anchor transamidase, putative | 0.0672 | 0.2175 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.2896 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | > 30 uM | Inhibition of PARP-1 (unknown origin) expressed in CHO-K1 cells assessed as depletion of NAD(P)H after 2 hr by CCK-8 assay | ChEMBL. | No reference |
IC50 (binding) | = 0.036 uM | Inhibition of PARP-1 (unknown origin) assessed as inhibition of biotinylated poly(ADP-ribose) onto histone proteins after 30 min by colorimetry | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.