Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0025 | 0.0163 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0097 | 0.0139 |
Brugia malayi | Lipase family protein | 0.0566 | 0.6987 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0616 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.031 | 0.0444 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0616 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0566 | 0.6987 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0048 | 0.0457 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0017 | 0.0066 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.031 | 0.0406 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0017 | 0.0066 | 0.0038 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0017 | 0.0066 | 0.2816 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0025 | 0.0163 | 0.0233 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0017 | 0.0066 | 0.0038 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0136 | 0.0155 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0025 | 0.0163 | 0.0194 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0097 | 0.0139 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0014 | 0.0028 | 0.004 |
Schistosoma mansoni | DNA polymerase eta | 0.0017 | 0.0066 | 0.0038 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.0136 | 0.2522 |
Mycobacterium leprae | putative cytochrome p450 | 0.0014 | 0.0028 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.0136 | 0.0155 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0566 | 0.6987 | 0.6979 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0566 | 0.6987 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0048 | 0.0457 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0066 | 0.0055 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.031 | 0.0444 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0566 | 0.6987 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0566 | 0.6987 | 0.6979 |
Giardia lamblia | DINP protein human, muc B family | 0.0025 | 0.0163 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0048 | 0.0457 | 0.043 |
Brugia malayi | polk-prov protein | 0.0036 | 0.031 | 0.0406 |
Loa Loa (eye worm) | lipase | 0.0566 | 0.6987 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Trypanosoma brucei | lipase domain protein, putative | 0.0566 | 0.6987 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0014 | 0.0028 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.0136 | 0.0155 |
Leishmania major | hypothetical protein, conserved | 0.0566 | 0.6987 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0048 | 0.0457 | 0.0654 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.0136 | 0.0155 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0566 | 0.6987 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0136 | 0.0155 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0017 | 0.0066 | 0.0038 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0097 | 0.0139 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0017 | 0.0066 | 0.0038 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Leishmania major | DNA polymerase kappa, putative | 0.0025 | 0.0163 | 0.0194 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0017 | 0.0066 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0017 | 0.0066 | 0.0038 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0017 | 0.0066 | 0.0055 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0136 | 0.0155 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0014 | 0.0028 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0017 | 0.0066 | 0.0055 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0048 | 0.0457 | 0.0654 |
Leishmania major | DNA polymerase eta, putative | 0.0017 | 0.0066 | 0.0055 |
Trypanosoma brucei | lipase domain protein, putative | 0.0566 | 0.6987 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0017 | 0.0066 | 0.0055 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.0136 | 0.0195 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0136 | 0.0155 |
Echinococcus multilocularis | dna polymerase eta | 0.0017 | 0.0066 | 0.0038 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.036 | 0.0515 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.0136 | 0.0155 |
Onchocerca volvulus | 0.0566 | 0.6987 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Brugia malayi | Cytochrome P450 family protein | 0.0051 | 0.0499 | 0.0677 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0051 | 0.0499 | 0.0677 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0616 |
Echinococcus multilocularis | dna polymerase kappa | 0.0048 | 0.0457 | 0.043 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0806 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0017 | 0.0066 | 0.0055 |
Trypanosoma brucei | unspecified product | 0.004 | 0.036 | 0.0515 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0806 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0616 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0048 | 0.0457 | 0.0654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.